St. Louis Cardinals vs San Diego Padres Prediction, 8/3/2025 MLB Picks, Best Bets & Odds

Game: St. Louis Cardinals vs San Diego Padres

Date: Sunday, August 3, 2025

Location: Petco Park in San Diego, CA

TV: Padres.TV

Odds/Point Spread: St. Louis (+172) San Diego (-210)

The St. Louis Cardinals (55-55) are headed to Petco Park on Sunday where they will compete against the San Diego Padres (60-49). The line on this contest has the Cardinals at +172 and the Padres open at -210. The total is 9. The pitchers taking the mound are Andre Pallante and Dylan Cease.

As a unit, the St. Louis Cardinals are earning 4.4 runs/g, which has them sitting at 14th in the league. They have earned a total of 483 runs scored while holding a team OBP of .320. The Cardinals have compiled 195 two-baggers as a team and have hit 105 baseballs out of the stadium. They have recorded 461 RBI's in addition to 924 base knocks on the season, and their team batting average is at .250. St. Louis has a slugging percentage of .389 and have been called out on strikes 840 times, while taking a walk on 346 occasions.

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They have earned a K/BB ratio of 2.78 and their pitching staff has a collective WHIP of 1.28. Cardinals pitchers have yielded 104 home runs and also 492 total runs (21st in the league). St. Louis has conceded 961 hits (8.9 per 9 innings) in addition to 451 earned runs. The Cardinals are sitting with a team earned run average of 4.17 for the year (19th in the league), and the staff has rung up 800 batters. They have walked 288 batters and their FIP comes in at 3.82 as a unit over the course of the season.

The Cardinals have dispatched 329 relief pitchers to the hill on the year. The relief pitchers have inherited 144 runners so far this year with 31.9% of them crossed home plate. They have recorded 26 saves this year and have blown 14 of 40 chances to get a save. The Cardinals bullpen have accumulated a save rate of 65.0% and have come into the game in 106 save situations. The relief pitchers have a total of 63 holds over the course of the season (13th in baseball). Cardinals relief pitchers have come into the game with runners on 106 times and also have had 106 appearances in high leverage situations.

The St. Louis Cardinals have amassed 2,918 putouts on the campaign, as well as 1,059 assists and 45 errors. Their fielding rate is holding steady at .989 which puts them in 5th in MLB, and have accumulated 83 double plays. The Cardinals have converted 69.4% of balls in play into outs out of 8,754 innings on the diamond, ranking them 20th in pro baseball.

Pallante (24-21 career win-loss record) has earned a FIP of 3.96 while he has gone up against 1,765 batters during his time in the major leagues. He has surrendered 415 hits (9.0 hits per 9 innings) and has 155 walks. His earned run average is 4.02 (185 ER's allowed) and his career WHIP is 1.376. Pallante has taken the hill for 414 frames and is sitting with 286 strikeouts in his MLB career.

San Diego has compiled 92 home runs on the campaign as well as 417 runs batted in. They have tallied 168 two-baggers, while getting a free base 344 times and putting up 445 runs. The San Diego Padres have accounted for a team OBP of .318 as well as a team batting average of .250 for the season. The Padres have a slugging percentage of .380 and they are scoring 4.08 runs per contest (24th in the league). They have struck out on 767 occasions (28th in the league) and are sitting with 911 hits.

The Padres have a WHIP of 1.216 and are the owners of a FIP of 3.87 as a pitching staff for the season. They sit at 1st in the league as a staff in total hits surrendered with 812. The San Diego pitching staff have surrendered 413 runs over the course of the season while holding an ERA of 3.55 (379 earned runs yielded). Their K/BB ratio is 8.60 (921 strikeouts vs 358 bases on balls). They have surrendered 106 homers and they concede 3.86 runs per 9 innings (3rd in baseball).

San Diego has called on bullpen pitchers to enter the contest in 49 save chances and they have walked away with 36 saves. They rank 2nd in MLB with a save rate of 73.5%, and they have sent 382 relievers to the hill over the course of the season. Their bullpen pitchers have come in 156 times in high leverage situations in addition to 129 occasions with runners on base. San Diego bullpen pitchers hold an inherited score percentage of 28.7% of 181 inherited base runners. Sitting with 127 save situations, the Padres have 75 holds in addition to 13 blown saves.

The San Diego Padres have gotten 80 double plays and have accounted for a fielding rate of .986 (13th in baseball). The Padres have 828 assists, 52 errors and have a tally of 2,886 putouts on the campaign. In their 8,658 innings on the field, the Padres have accumulated a defensive efficiency of 71.5% (3rd in pro baseball).

During his career, Cease has surrendered 813 hits while totaling 1,169 strikeouts in 965 innings. He has given up 416 ER's while holding a WHIP of 1.263 and having a FIP of 3.8. His strikeout to walk ratio is 2.88 and he has faced 4,093 opposing batters in his MLB career. Cease (60-56 win-loss mark in his career) holds a 3.88 earned run average while allowing 7.6 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take San Diego (-210)

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