Tampa Bay Rays vs Chicago White Sox Prediction, 9/10/2025 MLB Picks, Best Bets & Odds

Game: Tampa Bay Rays vs Chicago White Sox

Date: Wednesday, September 10, 2025

Location: Rate Field in Chicago, IL

TV: Chicago Sports Network

Odds/Point Spread: Tampa Bay (-144) Chicago (+120)

The Chicago White Sox (55-89) will try to beat the Tampa Bay Rays (71-72) at Rate Field on Wednesday. The line on this contest has Tampa Bay at -144 while Chicago is at +120. The total comes in at 8.5. The expected starting pitchers are Ryan Pepiot and Sean Burke.

Tampa Bay has a slugging rate of .403 and have been rung up 1,217 times, while being walked on 408 occasions. They have compiled 612 RBI's and 1,217 base knocks this year, and their batting average is at .252. The Rays have recorded 217 doubles as a team and have hit 160 baseballs out of the stadium. They have tallied 644 runs scored while having a team OBP of .314. As a squad, the Tampa Bay Rays are compiling 4.5 runs per game, which ranks them 14th in baseball.

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The Rays have a team ERA of 3.85 for the season (9th in baseball), and their staff has struck out 1,247 hitters. Rays pitchers have surrendered 185 home runs and also 589 total runs (6th in the league). Their pitching staff has walked 411 opposing players and their FIP is 4.19 as a squad this year. Tampa Bay has surrendered 1,119 base knocks (7.9 per 9 innings) in addition to 542 earned runs. They have a strikeout to walk ratio of 3.03 and their pitching staff holds a WHIP of 1.21.

The Rays have dispatched 453 relievers to the mound on the campaign. The relief pitchers have inherited 145 base runners on the season with 31.7% of those runners ended up crossing the plate. They have compiled 32 saves on the season and have not converted 24 of their 56 chances to save the game. The Rays relief pitchers have earned a save rate of 57.1% and have come into the game in 137 save situations. The bullpen have notched 79 holds this season (16th in baseball). Rays pitchers have gone to the mound with runners on base 97 times in addition to having 135 appearances in high leverage situations.

The Rays have transformed 70.9% of baseballs in play into outs out of 11,406 innings on the field, which has them sitting 4th in MLB. The Tampa Bay Rays have a tally of 3,802 putouts this season, as well as 1,257 assists and 67 errors. Their fielding percentage is holding at .987 which puts them in 11th in professional baseball, and have accumulated 130 double plays.

Pepiot has pitched in 371 frames and is sitting with 383 strikeouts so far in his pro baseball career. His earned run average is 3.42 (141 ER's allowed) and he has a WHIP of 1.129. He has conceded 282 base knocks (6.8 hits per nine innings) and has 137 walks. Pepiot (24-19 record in his career) is the owner of a FIP of 3.37 while he has faced 1,512 batters during his time in the majors.

The Chicago White Sox have earned an OBP of .305 in addition to a batting average of .236 on the campaign. They have been called out on strikes on 1,194 occasions (16th in baseball) and have recorded 1,131 hits. Chicago has 148 long balls on the year to go along with 562 runs batted in. The White Sox have a slugging percentage of .378 and they score 4.04 runs per outing (26th in MLB). They have 222 doubles, while walking 453 times and putting up 582 runs.

The Chicago pitching staff have allowed 662 runs for the season while holding a team ERA of 4.24 (593 earned runs given up). They have relinquished 160 dingers and they surrender 4.73 runs per 9 innings (22nd in the league). The White Sox hold a team WHIP of 1.367 in addition to having a FIP of 4.46 as a staff for the year. Their strikeout to walk ratio comes in at 8.00 (1,118 strikeouts against 534 bases on balls). They are sitting at 16th in MLB as a pitching staff in total hits allowed with 1,189.

Sitting with 103 save situations, the White Sox have accrued 60 holds in addition to 21 blown saves. Chicago has called on relief pitchers to enter the game in 43 save chances and they have come away with 22 saves. Their bullpen pitchers have stepped onto the mound 134 times in high leverage situations and on 142 occasions with base runners. Chicago bullpen pitchers hold an inherited score percentage of 32.2% out of 208 inherited runners. They are currently ranked 30th in MLB with a save percentage of 51.2%, and they have dispatched 464 bullpen pitchers onto the diamond so far this season.

In 11,343 innings on the field, the White Sox have a defensive efficiency of 69.6% (18th in professional baseball). The Chicago White Sox have turned 114 double plays and own a fielding percentage of .981 (28th in the majors). The White Sox have recorded 1,146 assists, 95 errors and have notched a total of 3,781 putouts for the year.

So far in his career, Burke has surrendered 128 hits while he has earned 132 strikeouts in 136 innings. He has given up a total of 59 ER's while earning a WHIP of 1.388 and being the owner of a FIP of 3.8. He has a K/BB ratio of 2.16 and he has faced 598 opposing hitters in his MLB career. Burke (6-10 career record) has a 3.90 ERA while allowing 8.5 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Chicago (+120)

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