Washington Nationals vs Chicago Cubs Prediction, 9/5/2025 MLB Picks, Best Bets & Odds

Game: Washington Nationals vs Chicago Cubs

Date: Friday, September 5, 2025

Location: Wrigley Field in Chicago, IL

TV: Marquee

Odds/Point Spread: Washington (+172) Chicago (-210)

The Chicago Cubs (80-60) will play the Washington Nationals (56-83) at Wrigley Field on Friday. The odds on this game have Washington at +172 while Chicago is priced at -210. The over/under comes in at 8. The men taking the mound will be Jake Irvin and Javier Assad.

As a unit, the Washington Nationals are putting up 4.2 runs per outing, which has them sitting at 23rd in the league. They have racked up 588 runs and have an OBP of .308. The Nationals have accrued 229 two-baggers as a unit and have hit 130 baseballs out of the park. They have amassed 565 runs batted in and 1,131 hits for the season, while their batting average is sitting at .243. Washington is slugging .386 and have struck out 1,123 times, while drawing a walk on 398 occasions.

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Their K/BB ratio is 2.27 and their pitching staff has a collective WHIP of 1.43. Nationals pitchers have given up 180 home runs and 758 runs (29th in MLB). Washington has conceded 1,269 hits (9.4 per 9 innings) and 716 earned runs. The Nationals have compiled a team ERA of 5.28 for the season (29th in the league), and their staff has struck out 1,070 batters. Their pitching staff has walked 471 hitters and their FIP sits at 4.66 as a team for the year.

Nationals relief pitchers have entered the contest with runners on base 136 times and also have had 103 appearances in high leverage situations. The relief pitchers have earned 63 holds so far this year (26th in MLB). The Nationals bullpen have recorded a save percentage of 65.1% and have come into the game in 107 save situations. They have compiled 28 saves this year and have missed out on 15 out of their 43 save opportunities. The bullpen pitchers have inherited 231 runners so far this season and 38.5% of them crossed home plate. The Nationals have sent 494 relief pitchers to the mound for the season.

The Nationals have converted 68.1% of balls hit into play into outs in their 10,974 innings, ranking them 29th in professional baseball. The Washington Nationals have amassed 3,658 putouts at this point in the season, in addition to 1,187 assists and 76 errors. Their fielding percentage is currently at .985 which ranks 20th in the majors, and have accumulated 108 double plays.

Irvin has taken the hill for 462 frames and is sitting with 357 punch outs thus far in his career. Irvin (21-31 career record) sits with a FIP of 4.74 while he has gone up against 1,972 opposing hitters during his time in the majors. His earned run average is 4.81 (247 earned runs allowed) and his career WHIP is 1.330. He has given up 456 hits (8.9 hits per nine innings) and has 159 free passes.

The Chicago Cubs hold an OBP of .319 as well as a team batting average of .249 so far this year. They have been rung up on 1,084 instances (27th in the league) and are sitting with 1,186 base hits. Chicago has accumulated 189 HRs on the season to go along with 672 RBIs. The Cubs have a SLG% of .427 and they are recording 4.91 runs per game (7th in MLB). They have notched 232 doubles, while getting a free base 471 times as well as scoring 688 runs.

The Chicago pitching staff have given up 573 runs for the year and come in with a team ERA of 3.88 (535 earned runs conceded). They have surrendered 173 long balls and they give up 4.15 runs per 9 innings (8th in the league). The Cubs have a team WHIP of 1.206 in addition to having a FIP of 4.21 as a team on the campaign. Their K/BB ratio sits at 7.80 (1,073 strikeouts against 364 walks). They are currently ranked 12th in baseball as a staff in total hits allowed with 1,134.

Sitting with 149 save situations, the Cubs have recorded 93 holds in addition to 16 blown saves. Chicago has had relievers enter the game in 53 save chances and they have earned 37 saves. Their relievers have stepped onto the mound 140 times in high leverage situations in addition to 90 occasions with runners on base. Chicago bullpen pitchers have an inherited score rate of 31.2% out of 125 inherited runners. They rank 3rd in MLB with a save rate of 69.8%, and they have sent 454 relief pitchers onto the diamond on the campaign.

The Chicago Cubs have turned 108 double plays and have a fielding percentage of .989 (5th in MLB). The Cubs have accrued 1,172 assists, 56 errors and have a total of 3,726 putouts on the season. In their 11,178 innings on the field, the Cubs hold a defensive efficiency of 71.5% (3rd in the majors).

Thus far in his career, Assad has allowed 293 base knocks while he has accumulated 258 strikeouts in 314 frames. Assad (15-12 career mark) has earned a 3.44 ERA while surrendering 8.4 hits per nine innings. He has given up a total of 120 earned runs while earning a WHIP of 1.344 and a FIP of 3.4. His K/BB ratio is 2.00 and he has faced 1,338 opposing hitters so far in his pro baseball career.

Who will win tonight's MLB game against the spread or moneyline?

Parlay's Pundit's Pick: Take Chicago (-210) and under 8 runs

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