Washington Nationals vs Chicago Cubs Prediction, 9/6/2025 MLB Picks, Best Bets & Odds

Game: Washington Nationals vs Chicago Cubs

Date: Saturday, September 6, 2025

Location: Wrigley Field in Chicago, IL

TV: Marquee

Odds/Point Spread: Washington (+120) Chicago (-144)

The Chicago Cubs (80-60) welcome the Washington Nationals (56-83) at Wrigley Field on Saturday. The line on this matchup has Washington at +120 while Chicago is at -144. The over/under has been set at 8. The expected starting pitchers will be Brad Lord and Matthew Boyd.

The Nationals have compiled 229 two-baggers as a unit and have hit 130 baseballs out of the stadium. Washington has a slugging rate of .386 and have struck out 1,123 times, while drawing a walk on 398 occasions. As a unit, the Washington Nationals are earning 4.2 runs per game, which ranks them 23rd in baseball. They have accrued 565 runs batted in in addition to 1,131 base knocks on the season, and their team batting average is .243. They have 588 runs and have an OBP of .308.

Get all of our MLB Parlay Picks

The Nationals hold a team ERA of 5.28 for the season (29th in baseball), and their staff has rung up 1,070 hitters. Nationals pitchers have conceded 180 home runs and also 758 total runs (29th in the league). Their pitching staff has walked 471 hitters and their FIP is 4.66 as a unit this year. Washington has given up 1,269 hits (9.4 per 9 innings) and also 716 earned runs. Their K/BB ratio is 2.27 and the pitching staff holds a collective WHIP of 1.43.

The Nationals bullpen have earned a save rate of 65.1% and have come into the game in 107 save situations. The bullpen pitchers have inherited 231 base runners so far this year and 38.5% of those runners earned a run for their team. Nationals pitchers have gone to the mound with runners on 136 times and also have had 103 appearances in high leverage situations. The Nationals have dispatched 494 relief pitchers to the mound on the campaign. The relievers have tallied 63 holds on the campaign (26th in the league). They have earned 28 saves on the campaign and have blown 15 out of their 43 save opportunities.

The Washington Nationals have amassed 3,658 putouts on the year, as well as 1,187 assists and 76 errors. Their fielding percentage is holding steady at .985 which has them ranked 20th in professional baseball, and have a total of 108 double plays. The Nationals have converted 68.1% of balls in play into outs out of their 10,974 innings, which has them sitting 29th in baseball.

Lord has pitched in 103 frames and is sitting with 85 K's so far in his pro baseball career. Lord (4-8 career win-loss record) holds a FIP of 4.30 while he has gone up against 436 batters in the majors. His ERA is 4.36 (50 ER's allowed) and his WHIP is 1.328. He has surrendered 102 hits (8.9 hits per nine innings) and has 35 free passes.

The Cubs have a SLG% of .427 and they are scoring 4.91 runs per game (7th in MLB). They have 232 two-baggers, while taking a walk 471 times as well as scoring 688 runs. Chicago is sitting with 189 home runs on the campaign as well as 672 runs batted in. They have struck out on 1,084 occasions (27th in baseball) and are sitting with 1,186 base hits. The Chicago Cubs have accumulated a team on-base percentage of .319 as well as a team batting average of .249 over the course of the season.

The Cubs have a WHIP of 1.206 with a FIP of 4.21 as a unit this year. Their K/BB ratio sits at 7.80 (1,073 strikeouts vs 364 bases on balls). They have a ranking of 12th in baseball as a pitching staff in total hits given up with 1,134. They have conceded 173 dingers and they surrender 4.15 runs per 9 innings (8th in MLB). The Chicago pitching staff have allowed 573 runs this year while holding a team ERA of 3.88 (535 earned runs conceded).

Sitting with 149 save situations, the Cubs have accrued 93 holds in addition to 16 blown saves. Chicago has called on bullpen pitchers to enter the contest in 53 save opportunities and they have walked away with 37 saves. Their relievers have stepped onto the mound 140 times in high leverage situations and on 90 occasions with runners on. Chicago relief pitchers hold an inherited score percentage of 31.2% of 125 inherited runners. They rank 3rd in MLB with a save percentage of 69.8%, and they have sent 454 relief pitchers to the hill over the course of the season.

In their 11,178 innings on the field, the Cubs have earned a efficiency on defense of 71.5% (3rd in baseball). The Chicago Cubs have gotten 108 double plays and have a fielding percentage of .989 (5th in baseball). The Cubs have accrued 1,172 assists, 56 errors and have accumulated 3,726 putouts for the season.

Boyd (58-76 mark in his career) holds a 4.56 ERA and has given up 8.7 hits per 9 innings. His strikeout to walk ratio is 3.12 and he has faced 4,528 opposing batters so far in his career. He has allowed 541 ER's while earning a WHIP of 1.277 and being the owner of a FIP of 4.5. During his MLB career, Boyd has surrendered 1,032 hits while he has earned 1,033 strikeouts in 1,067 innings pitched.

Who will win tonight's MLB game against the spread or moneyline?

Parlay's Pundit's Pick: Take Chicago (-144) and under 8 runs

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here