Washington Nationals vs New York Mets Prediction, 9/21/2025 MLB Picks, Best Bets & Odds

Game: Washington Nationals vs New York Mets

Date: Sunday, September 21, 2025

Location: Citi Field in Queens, NY

TV: Sportsnet New York

Odds/Point Spread: Washington (+106) New York (-128)

The Washington Nationals (62-91) are on their way to Citi Field on Sunday where they will try to defeat the New York Mets (79-74). The moneyline on this contest has the Nationals at +106 and the Mets are priced at -128. The over/under has been set at 9. The men taking the mound will be Cade Cavalli and Nolan McLean.

The Nationals have accrued 249 two-baggers as a team and have smacked 143 baseballs out of the stadium. Washington has a slugging percentage of .386 and have struck out 1,253 times, while being walked on 425 occasions. As a unit, the Washington Nationals are scoring 4.2 runs per game, which has them sitting at 24th in the league. They have accounted for 621 RBI's and 1,244 hits for the season, while their batting average comes in at .243. They have notched a total of 647 runs scored while holding a team OBP of .306.

Get all of our MLB Picks

They have a K/BB ratio of 2.19 and the pitching staff has a collective WHIP of 1.44. Nationals pitchers have allowed 198 long balls and 842 runs in total (29th in MLB). Washington has given up 1,401 base hits (9.4 per 9 innings) and 796 earned runs. The Nationals have a team earned run average of 5.33 over the course of the season (29th in the league), and their staff has rung up 1,166 hitters. They have walked 533 opposing hitters and their FIP is 4.70 as a unit on the campaign.

Nationals bullpen pitchers have come into the game with players on base 151 times as well as having 123 appearances in high leverage situations. The relief pitchers have 69 holds this year (25th in baseball). The Nationals relief pitchers have accumulated a save rate of 64.7% and have entered the game in 121 save situations. They have earned 33 saves for the year and have blown 18 out of their 51 save opportunities. The bullpen pitchers have inherited 254 runners on the season and 40.2% of those players ended up scoring. The Nationals have dispatched 545 relief pitchers to the mound over the course of the season.

The Washington Nationals have 4,030 putouts this year, as well as 1,318 assists and 85 errors. Their fielding percentage sits at .984 which puts them in 22nd in professional baseball, and have earned 125 double plays. The Nationals have transformed 68.1% of balls in play into outs in their 12,090 innings on the diamond, which ranks them 28th in professional baseball.

Cavalli has pitched in 43 frames and has accumulated 37 strikeouts so far in his pro baseball career. His earned run average is 5.82 (28 ER's allowed) and his career WHIP is 1.524. He has allowed 51 base hits (10.6 hits per nine innings) with 15 free passes. Cavalli (3-2 career record) has earned a FIP of 5.73 while going up against 200 hitters in the major leagues.

The Mets hold a team slugging percentage of .429 and they have an average of 4.72 runs per outing (11th in the league). They have 248 two-baggers, while getting a free base 533 times as well as recording 722 runs. New York has 213 home runs this year as well as 704 RBIs. They have struck out on 1,248 instances (19th in baseball) and have notched a total of 1,283 hits. The New York Mets have accumulated an OBP of .327 and a team batting average of .249 on the season.

The New York pitching staff have allowed 669 runs on the season while having a team ERA of 4.00 (601 earned runs surrendered). They have conceded 140 long balls and they allow 4.45 runs per 9 innings (18th in baseball). The Mets hold a team WHIP of 1.333 with a FIP of 3.92 as a team this year. Their K/BB ratio comes in at 8.70 (1,305 strikeouts vs 534 free passes). They are sitting at 16th in the league as a staff in total hits surrendered with 1,268.

Sitting with 157 save situations, the Mets have earned 92 holds in addition to 27 blown saves. New York has called on bullpen pitchers to take the mound in 65 save chances and they have recorded 38 saves. Their bullpen pitchers have stepped onto the mound 178 times in high leverage situations in addition to 162 occasions with runners on base. New York relief pitchers hold an inherited score rate of 34.7% of 242 inherited runners. They are currently ranked 23rd in baseball with a save percentage of 58.5%, and they have sent 499 relievers to the mound on the year.

The New York Mets have gotten 115 double plays and hold a fielding percentage of .987 (9th in pro baseball). The Mets have racked up 1,374 assists, 70 errors and have a tally of 4,029 putouts over the course of the season. In 12,087 innings played, the Mets are sitting with a defensive efficiency of 68.8% (24th in pro baseball).

So far in his pro baseball career, McLean has surrendered 25 base knocks while tallying 40 strikeouts in 37 frames. He has conceded 5 ER's while earning a WHIP of 0.995 and a FIP of 1.2. His K/BB ratio is 3.33 and he has faced 143 opposing hitters in his MLB career. McLean (4-1 mark in his career) is the owner of a 1.21 ERA while conceding 6.0 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Washington (+106)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here