Arizona Diamondbacks vs Colorado Rockies Prediction, 9/22/2026 MLB Picks, Best Bets & Odds

Game: Arizona Diamondbacks vs Colorado Rockies

Date: Tuesday, September 22, 2026

Location: Coors Field in Denver, CO

TV: Rockies.TV

Odds/Point Spread: Arizona (-152) Colorado (+126)

Coors Field is the location where the Colorado Rockies (57-99) will try to beat the Arizona Diamondbacks (82-74) on Tuesday. The moneyline on this matchup has Arizona at -152 and Colorado is priced at +126. The betting total is set at 8.5. The expected starting pitchers will be Michael Soroka and Kyle Freeland.

The Diamondbacks have tallied 258 two-baggers as a team and have knocked 157 balls out of the park. Arizona has a slugging percentage of .398 and have struck out 1,155 times, while being walked on 519 occasions. As a squad, the Arizona Diamondbacks are knocking in 4.4 runs per game, which ranks them 15th in the league. They have accumulated 662 runs batted in and 1,276 base knocks over the course of the season, and their team batting average sits at .244. They have tallied 693 runs scored and hold an OBP of .316.

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The Diamondbacks have a team ERA of 4.11 so far this year (12th in the league), and they have rung up 1,094 batters. Diamondbacks pitchers have conceded 178 home runs and 694 runs in total (16th in baseball). They have walked 467 opposing players and their FIP is 4.33 as a team this season. Arizona has yielded 1,307 hits (8.5 per 9 innings) as well as 634 earned runs. They have earned a K/BB ratio of 2.34 and the pitching staff has earned a collective WHIP of 1.28.

The Diamondbacks bullpen have earned a save percentage of 67.3% and have stepped onto the mound in 137 save situations. They have compiled 37 saves so far this season and have blown 18 of 55 save chances. The relievers have inherited 201 runners so far this year and 26.9% of them crossing the plate. Diamondbacks pitchers have gone to the mound with players on base 139 times in addition to having 167 appearances in high leverage situations. The Diamondbacks have dispatched 527 relievers to the mound so far this year. The bullpen have 81 holds this season (19th in the league).

The Diamondbacks have turned 71.3% of balls hit into play into outs out of 12,510 innings on the field, ranking them 7th in baseball. The Arizona Diamondbacks have earned 4,170 putouts for the season, as well as 1,347 assists and 62 errors. Their fielding percentage is holding at .989 which has them ranked 2nd in baseball, and they have turned 134 double plays.

Soroka has pitched in 519 innings and has 480 punch outs during his MLB career. Soroka (28-31 career mark) sits with a FIP of 3.72 and he has gone up against 2,171 opposing batters in the majors. His ERA is 3.78 (218 earned runs allowed) and his career WHIP is 1.205. He has conceded 460 hits (8.0 hits per nine innings) and has had 166 walks.

The Colorado Rockies have recorded a team OBP of .323 and a batting average of .254 this year. They have struck out on 1,357 instances (7th in MLB) and have 1,351 base knocks. Colorado has recorded 170 HRs over the course of the season as well as 696 RBIs. The Rockies have a team slugging percentage of .416 and they earn 4.66 runs per contest (7th in baseball). They have recorded 273 doubles, while walking 489 times and scoring 727 runs.

The Rockies hold a team WHIP of 1.526 in addition to having a FIP of 4.84 as a unit for the year. They come in at 30th in the league as a pitching staff in total hits given up with 1,570. The Colorado pitching staff have allowed 904 runs so far this season while holding an ERA of 5.57 (848 earned runs conceded). Their strikeout to walk ratio comes in at 7.00 (1,072 strikeouts against 519 bases on balls). They have conceded 215 homers and they allow 5.94 runs per 9 innings (30th in baseball).

Colorado relievers have an inherited score rate of 31.8% out of 239 inherited runners. Their relievers have stepped onto the mound 149 times in high leverage situations and on 155 occasions with runners on. With 122 save situations, the Rockies have amassed 60 holds and 25 blown saves. They rank 24th in MLB holding a save percentage of 56.9%, and they have sent 483 bullpen pitchers to the hill this year.

In 12,327 innings on the field, the Rockies have earned a defensive efficiency of 66.8% (30th in baseball). The Colorado Rockies have gotten 125 double plays and own a fielding percentage of .983 (27th in the majors). The Rockies have accrued 1,301 assists, 95 errors and are sitting with 4,109 putouts this year.

So far in his MLB career, Freeland has allowed 1,555 hits and he has 1,048 punch outs in 1,388 innings. Freeland (69-100 career record) is the owner of a 4.71 earned run average and has surrendered 10.1 hits per 9 innings. He has conceded a total of 727 ER's while holding a WHIP of 1.423 and a FIP of 4.6. He has a strikeout to walk ratio of 2.50 and he has faced 6,040 batters during his MLB career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Arizona (-152)

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