Arizona Diamondbacks vs San Diego Padres Prediction, 9/26/2026 MLB Picks, Best Bets & Odds

Game: Arizona Diamondbacks vs San Diego Padres

Date: Saturday, September 26, 2026

Location: Petco Park in San Diego, CA

TV: Padres.TV

Odds/Point Spread: Arizona (+126) San Diego (-152)

Petco Park is the site where the San Diego Padres (89-70) will compete against the Arizona Diamondbacks (85-74) on Saturday. The moneyline on this contest has Arizona at +126 while San Diego is opening at -152. The over/under is set at 8.5. The starting pitchers are Corbin Burnes and Walker Buehler.

The Diamondbacks have hit 265 two-baggers as a team and have hit 162 baseballs out of the stadium. Arizona has a slugging rate of .402 and have been called out on strikes 1,175 times, while being walked on 526 occasions. As a unit, the Arizona Diamondbacks are scoring 4.5 runs per game, which is 12th in baseball. They have accounted for 686 RBI's and 1,315 base knocks for the year, while their team batting average is sitting at .246. They have a total of 717 runs scored while holding a team on-base percentage of .317.

Get all of our Free MLB Picks

They have accrued a K/BB ratio of 2.37 and their pitching staff has recorded a WHIP of 1.27. Diamondbacks pitchers have given up 183 home runs and 707 runs (15th in MLB). Arizona has given up 1,334 base knocks (8.5 per 9 innings) in addition to 646 earned runs. The Diamondbacks are sitting with a team earned run average of 4.10 on the season (13th in baseball), and their staff has struck out 1,118 hitters. They have walked 471 opposing batters and their FIP is 4.33 as a team this season.

The Diamondbacks bullpen have a save rate of 67.9% and have come into the game in 141 save situations. They have compiled 38 saves for the year and have not converted 18 of their 56 save chances. The relief pitchers have inherited 202 base runners so far this season with 26.7% of those runners crossing home plate. Diamondbacks relief pitchers have stepped onto the hill with players on base 140 times as well as having 170 appearances in high leverage situations. The Diamondbacks have sent 536 relievers to the mound for the year. The bullpen have a total of 84 holds for the year (15th in the league).

The Diamondbacks have turned 71.3% of balls in play into outs out of 12,753 innings on the field, which ranks them 6th in baseball. The Arizona Diamondbacks have earned 4,251 putouts at this point in the season, in addition to 1,368 assists and 64 errors. Their fielding percentage is currently at .989 which puts them in 3rd in baseball, and have a total of 135 double plays.

Burnes (63-38 career record) is the owner of a FIP of 3.15 while he has gone up against 3,961 batters in the major leagues. He has given up 768 base knocks (7.1 hits per nine innings) and has 284 free passes. His ERA is 3.20 (348 ER's allowed) and he has a career WHIP of 1.076. Burnes has taken the mound for 978 innings and has earned 1,122 punch outs during his MLB career.

The Padres have a team slugging percentage of .397 and they average 4.40 runs per contest (19th in baseball). They have 230 doubles, while walking 542 times as well as putting up 699 runs. San Diego has a total of 180 home runs so far this season as well as 673 runs batted in. They have struck out on 1,288 occasions (21st in baseball) and have tallied 1,280 hits. The San Diego Padres have tallied an on-base percentage of .318 in addition to a batting average of .243 over the course of the season.

The Padres are sitting with a team WHIP of 1.289 with a FIP of 4.16 as a staff so far this season. They have earned a strikeout to walk ratio of 8.30 (1,295 strikeouts against 539 bases on balls). They are sitting at 13th in the league as a staff in total hits conceded with 1,278. They have relinquished 176 homers and they relinquish 4.21 runs per 9 innings (9th in baseball). The San Diego pitching staff have yielded 659 runs so far this year while holding a team ERA of 3.93 (615 earned runs conceded).

They are ranked 7th in baseball with a save percentage of 71.6%, and they have sent 540 relievers to the mound over the course of the season. Their relief pitchers have come in 185 times in high leverage situations and on 152 occasions with runners on. Sitting with 177 save situations, the Padres have tallied 105 holds and also 19 blown saves. San Diego has had relief pitchers step onto the hill in 67 save opportunities and they have come away with 48 saves. San Diego relievers hold an inherited score percentage of 31.2% of 247 inherited runners.

In their 12,684 innings played, the Padres have accumulated a defensive efficiency of 70.6% (10th in MLB). The San Diego Padres have gotten 128 double plays and own a fielding percentage of .989 (2nd in professional baseball). The Padres have 1,401 assists, 63 errors and have notched a total of 4,228 putouts over the course of the season.

During his career, Buehler has allowed 863 hits while he has earned 974 punch outs in 989 innings. He has surrendered a total of 404 earned runs while holding a WHIP of 1.183 and having a FIP of 3.6. His K/BB ratio is 3.17 and he has faced 4,100 hitters so far in his pro baseball career. Buehler (66-35 career mark) has earned a 3.68 ERA while conceding 7.9 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take San Diego (-152)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get MLB picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.