Baltimore Orioles vs Boston Red Sox Prediction, 7/22/2026 MLB Picks, Best Bets & Odds

Game: Baltimore Orioles vs Boston Red Sox

Date: Wednesday, July 22, 2026

Location: Fenway Park in Boston, MA

TV: NESN

Odds/Point Spread: Baltimore (+162) Boston (-196)

The Baltimore Orioles (49-52) are hitting the road to Fenway Park on Wednesday where they will take on the Boston Red Sox (51-48). The line on this matchup has the Orioles at +162 and the Red Sox are coming in at -196. The over/under has been set at 8. The pitchers who are expected to start are Dean Kremer and Jake Bennett.

Baltimore is slugging .398 and have been called out on strikes 933 times, while taking a walk on 390 occasions. They have accumulated 448 RBI's as well as 798 hits on the year, while their team batting average comes in at .238. The Orioles have tallied 153 doubles as a unit and have smacked 120 balls out of the stadium. They have racked up 464 runs and hold an OBP of .321. As a squad, the Baltimore Orioles are knocking in 4.6 runs per outing, which ranks them 11th in MLB.

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Their strikeout to walk ratio sits at 2.32 and their pitching staff sits with a WHIP of 1.35. Orioles pitchers have surrendered 110 home runs and also 478 runs in total (20th in baseball). Baltimore has conceded 865 base hits (8.7 per 9 innings) and 420 earned runs. The Orioles are sitting with a team ERA of 4.21 this year (14th in baseball), and they have struck out 801 hitters. Their pitching staff has walked 345 opposing batters and their FIP is 4.15 as a team on the season.

The Orioles relief pitchers have a save percentage of 65.8% and stepped onto the hill in 92 save situations. They have earned 25 saves for the season and have blown 13 out of their 38 save opportunities. The relievers have inherited 128 runners for the season with 26.6% of them crossing the plate. Orioles relief pitchers have come into the game with runners on 93 times as well as having 99 appearances in high leverage situations. The Orioles have dispatched 330 relief pitchers to the mound on the year. The relief pitchers have racked up 53 holds this season (15th in baseball).

The Baltimore Orioles have a tally of 2,693 putouts this year, in addition to 871 assists and 67 errors. Their fielding percentage is holding at .982 which is 27th in pro baseball, and have a total of 73 double plays. The Orioles have turned 69.0% of balls in play into outs out of 8,079 innings on the diamond, which has them sitting at 23rd in baseball.

Kremer (42-42 mark in his career) is the owner of a FIP of 4.20 while going up against 2,939 hitters in the major leagues. He has given up 667 hits (8.6 hits per 9 innings) with 229 free passes. His ERA is 4.26 (330 earned runs allowed) and his WHIP is 1.285. Kremer has taken the mound for 697 innings and has 607 K's in his MLB career.

The Red Sox hold a team slugging percentage of .394 and they tally 4.23 runs per game (22nd in the league). They have 175 doubles, while taking a walk 298 times and earning 419 runs. Boston has recorded 95 long balls so far this season as well as 401 RBIs. They have been rung up on 811 occasions (23rd in baseball) and have recorded 809 base hits. The Boston Red Sox have compiled an OBP of .315 and a team batting average of .245 for the year.

The Boston pitching staff have conceded 373 runs on the year while having an ERA of 3.55 (346 earned runs given up). They have given up 101 dingers and they surrender 3.83 runs per 9 innings (3rd in baseball). The Red Sox have a WHIP of 1.220 and have a FIP of 3.78 as a team this season. Their K/BB ratio is 8.70 (844 strikeouts against 286 walks). They are currently ranked 9th in baseball as a staff in total hits given up with 784.

They are ranked 4th in the league with a save rate of 74.3%, and they have dispatched 305 relievers onto the field on the season. Their bullpen pitchers have taken the field 85 times in high leverage situations in addition to 80 occasions with base runners. With 97 save situations, the Red Sox have recorded 60 holds in addition to 9 blown saves. Boston has called on bullpen pitchers to step onto the mound in 35 save chances and they have earned 26 saves. Boston bullpen pitchers hold an inherited score rate of 31.3% of 115 inherited base runners.

In their 7,896 innings on the field, the Red Sox are sitting with a efficiency on defense of 70.3% (13th in the majors). The Boston Red Sox have gotten 66 double plays and own a fielding percentage of .987 (10th in professional baseball). The Red Sox have racked up 843 assists, 45 errors and have 2,632 putouts over the course of the season.

In his pro baseball career, Bennett has surrendered 38 base knocks while he has tallied 38 K's in 53 frames. He has surrendered 14 earned runs while earning a WHIP of 0.883 and a FIP of 2.3. His K/BB ratio is 4.22 and he has faced 203 opposing hitters in his career. Bennett (5-3 win-loss record in his career) has a 2.37 ERA and has given up 6.4 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Baltimore (+162)

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