Baltimore Orioles vs Kansas City Royals Prediction, 4/22/2026 MLB Picks, Best Bets & Odds

Game: Baltimore Orioles vs Kansas City Royals

Date: Wednesday, April 22, 2026

Location: Kauffman Stadium in Kansas City, MO

TV: MLB.TV

Odds/Point Spread: Baltimore (-132) Kansas City (+110)

The Kansas City Royals (7-16) will play the Baltimore Orioles (11-12) at Kauffman Stadium on Wednesday. The moneyline on this matchup has Baltimore at -132 and Kansas City is sitting at +110. The betting total is set at 9. The pitchers who are expected to start will be Chris Bassitt and Michael Wacha.

Baltimore is slugging .367 and have been called out on strikes 224 times, while being walked on 96 occasions. They have accrued 97 RBI's as well as 172 base knocks on the campaign, and their average at the plate is sitting at .226. The Orioles have hit 39 two-baggers as a unit and have hit 22 balls out of the park. They have earned 98 runs while having a team OBP of .317. As a unit, the Baltimore Orioles are scoring 4.3 runs per contest, which has them at 17th in MLB.

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They have a K/BB ratio of 2.55 and the pitching staff holds a WHIP of 1.35. Orioles pitchers have given up 24 long balls and also 103 runs (17th in baseball). Baltimore has given up 194 base hits (8.5 per 9 innings) and 87 earned runs. The Orioles hold a team ERA of 3.81 for the year (11th in MLB), and their staff has struck out 209 batters. Their pitching staff has walked 82 opposing players and their FIP is 3.97 as a unit this season.

The Orioles have dispatched 78 relievers to the hill on the year. The relievers have inherited 26 base runners this year with 11.5% of them ended up scoring. The relief pitchers have earned 16 holds this year (9th in the league). Orioles pitchers have stepped onto the hill with players on base 19 times in addition to having 31 appearances in high leverage situations. They have tallied 8 saves on the year and have blown 2 out of their 10 save chances. The Orioles relief pitchers have recorded a save percentage of 80.0% and have stepped onto the mound in 27 save situations.

The Orioles have converted 68.1% of baseballs in play into outs out of their 1,848 innings on the field, which has them ranked 25th in baseball. The Atlanta Braves have a tally of 616 putouts on the year, as well as 198 assists and 13 errors. Their fielding rate sits at .984 which has them sitting 19th in baseball, and have earned 19 double plays.

Bassitt (83-67 career record) sits with a FIP of 3.62 and he has faced 5,493 opposing hitters in the major leagues. He has surrendered 1,207 base hits (8.4 hits per nine innings) and has 420 walks. His ERA is 3.67 (528 earned runs allowed) and he has a career WHIP of 1.257. Bassitt has taken the mound for 1,294 innings and has earned 1,198 strikeouts during his career.

The Kansas City Royals have recorded a team on-base percentage of .302 in addition to a batting average of .223 this season. They have been rung up on 201 occasions (11th in the league) and have earned 167 hits. Kansas City is sitting with 18 home runs so far this season as well as 72 RBIs. The Royals hold a team slugging percentage of .342 and they score 3.30 runs per contest (29th in the league). They have hit 31 doubles, while walking 78 times and recording 76 runs.

The Kansas City pitching staff have allowed 110 runs on the season while holding an ERA of 4.56 (102 earned runs given up). They have surrendered 29 home runs and they surrender 4.92 runs per 9 innings (21st in MLB). The Royals have a team WHIP of 1.377 and have a FIP of 4.66 as a squad for the season. Their strikeout to walk ratio is 8.90 (198 strikeouts against 104 walks). They sit at 11th in MLB as a pitching staff in total hits allowed with 173.

Kansas City relief pitchers hold an inherited score percentage of 26.3% of 19 inherited base runners. Their relief pitchers have come in 22 times in high leverage situations and on 14 occasions with runners on base. Sitting with 23 save situations, the Royals have 11 holds in addition to 5 blown saves. They rank 19th in MLB with a save percentage of 58.3%, and they have dispatched 68 relief pitchers to the hill for the year.

Out of their 1,812 innings played, the Royals have earned a efficiency on defense of 71.7% (6th in professional baseball). The Kansas City Royals have gotten 19 double plays and have a fielding percentage of .991 (4th in MLB). The Royals have 186 assists, 7 errors and have earned 604 putouts this season.

During his career, Wacha has allowed 1,584 base hits while he has tallied 1,439 K's in 1,654 frames. Wacha (113-75 career record) is the owner of a 3.84 earned run average and has surrendered 8.6 hits per 9 innings. He has conceded 706 ER's while earning a WHIP of 1.267 and having a FIP of 3.8. He has a strikeout to walk ratio of 2.82 and he has gone up against 6,944 hitters in his pro baseball career.

Who will win tonight's MLB game against the spread or moneyline?

Parlay's Pundit's Pick: Take Kansas City (+110) and under 9 runs

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