Baltimore Orioles vs St. Louis Cardinals Prediction, 8/26/2026 MLB Picks, Best Bets & Odds

Game: Baltimore Orioles vs St. Louis Cardinals

Date: Wednesday, August 26, 2026

Location: Busch Stadium in St. Louis, MO

TV: Cardinals.TV

Odds/Point Spread: Baltimore (-160) St. Louis (+132)

Busch Stadium is the site where the St. Louis Cardinals (66-66) will take on the Baltimore Orioles (63-68) on Wednesday. The odds on this game have Baltimore at -160 while St. Louis is priced at +132. The total is set at 8.5. The starting pitchers are Kyle Bradish and Michael McGreevy.

The Orioles have compiled 188 two-baggers as a team and have knocked 159 balls out of the park. Baltimore has a slugging rate of .396 and have been called out on strikes 1,202 times, while drawing a walk on 491 occasions. As a unit, the Baltimore Orioles are notching 4.5 runs per game, which is 16th in baseball. They have 563 RBI's as well as 1,020 base knocks this year, while their team batting average comes in at .235. They have accumulated 583 runs scored and have an OBP of .317.

Get all of our MLB Expert Picks

The Orioles have compiled a team ERA of 4.19 this year (19th in MLB), and their staff has rung up 1,038 batters. Orioles pitchers have surrendered 139 home runs and 618 runs in total (22nd in MLB). Their pitching staff has walked 435 opposing batters and their FIP sits at 4.07 as a squad on the year. Baltimore has relinquished 1,132 base hits (8.7 per 9 innings) and 543 earned runs. They have earned a strikeout to walk ratio of 2.39 and their pitching staff has a collective WHIP of 1.34.

Orioles relief pitchers have stepped onto the hill with players on base 123 times in addition to having 132 appearances in high leverage situations. The bullpen have tallied 68 holds for the season (17th in the league). The Orioles bullpen have earned a save rate of 65.4% and stepped onto the hill in 123 save situations. They have recorded 34 saves over the course of the season and have blown 18 of 52 save opportunities. The bullpen pitchers have inherited 166 runners for the year with 29.5% of those players earned a run for their team. The Orioles have sent 432 relief pitchers to the hill on the campaign.

The Orioles have converted 68.8% of balls in play into outs out of their 10,491 innings, which has them ranked 26th in professional baseball. The Baltimore Orioles have a tally of 3,497 putouts this year, in addition to 1,129 assists and 82 errors. Their fielding rate sits at .983 which ranks 24th in MLB, and they have turned 98 double plays.

Bradish has taken the hill for 495 innings and has earned 508 punch outs so far in his career. His ERA is 3.54 (195 ER's allowed) and he has a career WHIP of 1.225. He has given up 432 hits (7.8 hits per 9 innings) and has 175 free passes. Bradish (26-27 career win-loss record) has a FIP of 3.49 while facing 2,056 batters during his time in the majors.

St. Louis is sitting with 137 home runs on the season to go along with 570 RBIs. They have tallied 187 two-baggers, while taking a walk 427 times and putting up 585 runs. The St. Louis Cardinals have earned an OBP of .317 and a batting average of .241 for the year. The Cardinals have a team slugging percentage of .382 and they are scoring 4.43 runs per game (18th in baseball). They have been called out on strikes on 1,030 occasions (27th in the league) and have notched a total of 1,069 hits.

The Cardinals have a WHIP of 1.335 in addition to having a FIP of 4.07 as a pitching staff so far this year. Their strikeout to walk ratio comes in at 7.80 (1,015 strikeouts vs 446 walks). They are currently ranked 22nd in baseball as a pitching staff in total hits surrendered with 1,124. They have given up 129 dingers and they yield 4.49 runs per 9 innings (16th in MLB). The St. Louis pitching staff have given up 587 runs this season while having an ERA of 4.14 (541 earned runs relinquished).

With 152 save situations, the Cardinals have accumulated 86 holds and also 24 blown saves. St. Louis has had relievers enter the contest in 62 save opportunities and they have walked away with 38 saves. St. Louis relief pitchers have an inherited score percentage of 39.0% out of 200 inherited base runners. Their bullpen pitchers have come in 165 times in high leverage situations in addition to 134 occasions with base runners. They sit at 18th in baseball holding a save rate of 61.3%, and they have sent 441 bullpen pitchers to the hill so far this year.

In 10,584 innings on the diamond, the Cardinals have accumulated a defensive efficiency of 69.4% (23rd in professional baseball). The St. Louis Cardinals have gotten 131 double plays and have earned a fielding percentage of .989 (4th in the majors). The Cardinals have recorded 1,239 assists, 55 errors and have accounted for 3,528 putouts so far this season.

During his pro baseball career, McGreevy has surrendered 246 hits while he has accumulated 171 K's in 255 innings pitched. He has given up 106 ER's while holding a WHIP of 1.191 and being the owner of a FIP of 3.7. He has a strikeout to walk ratio of 2.95 and he has gone up against 1,044 hitters in his career. McGreevy (16-13 career win-loss mark) has a 3.74 earned run average while conceding 8.7 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take St. Louis (+132)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get MLB picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.