Baltimore Orioles vs St. Louis Cardinals Prediction, 8/27/2026 MLB Picks, Best Bets & Odds

Game: Baltimore Orioles vs St. Louis Cardinals

Date: Thursday, August 27, 2026

Location: Busch Stadium in St. Louis, MO

TV: Cardinals.TV

Odds/Point Spread: Baltimore (-145) St. Louis (+125)

The Baltimore Orioles (64-68) are headed to Busch Stadium on Thursday where they will meet the St. Louis Cardinals (66-67). The odds on this game have Baltimore at -145 and St. Louis is sitting at +125. The over/under is set at 8.5. The starting pitchers will be Trevor Rogers and Quinn Mathews.

As a unit, the Baltimore Orioles are putting up 4.5 runs per game, which has them sitting at 14th in the league. They have tallied 596 runs scored and have an OBP of .318. The Orioles have compiled 192 doubles as a team and have knocked 161 baseballs out of the park. They have amassed 576 RBI's as well as 1,036 base knocks this season, while their average at the plate is at .236. Baltimore has a slugging rate of .398 and have been called out on strikes 1,215 times, while being walked on 493 occasions.

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The Orioles have compiled a team earned run average of 4.17 on the year (17th in baseball), and they have struck out 1,048 hitters. Orioles pitchers have conceded 140 home runs and also 619 runs (21st in MLB). They have walked 435 batters and their FIP sits at 4.06 as a team so far this season. Baltimore has conceded 1,139 hits (8.7 per 9 innings) as well as 544 earned runs. Their strikeout to walk ratio sits at 2.41 and the pitching staff holds a collective WHIP of 1.34.

The Orioles relief pitchers have a save rate of 65.4% and have come into the game in 123 save situations. They have earned 34 saves on the season and have blown 18 of 52 chances to get a save. The bullpen pitchers have inherited 167 runners for the season with 29.3% of those players ended up crossing the plate. Orioles pitchers have gone to the mound with runners on 124 times as well as having 132 appearances in high leverage situations. The Orioles have sent 434 relievers to the hill this year. The bullpen have earned 68 holds on the season (17th in MLB).

The Orioles have transformed 68.8% of balls hit into play into outs out of their 10,572 innings on the field, which has them sitting 26th in the majors. The Baltimore Orioles have earned 3,524 putouts over the course of the season, as well as 1,136 assists and 82 errors. Their fielding percentage is holding steady at .983 which ranks 24th in MLB, and they have turned 99 double plays.

Rogers (33-45 win-loss mark in his career) holds a FIP of 3.83 while he has faced 2,777 batters in the majors. He has conceded 609 hits (8.4 hits per nine innings) and has 231 walks. His ERA is 3.89 (282 earned runs allowed) and he has a WHIP of 1.288. Rogers has taken the hill for 652 innings and has accumulated 635 punch outs thus far in his career.

The Cardinals hold a slugging % of .381 and they earn 4.41 runs per outing (18th in baseball). They have tallied 187 doubles, while getting a free base 427 times as well as putting up 586 runs. St. Louis has hit 138 home runs this year as well as 571 runs batted in. They have been called out on strikes on 1,040 occasions (26th in MLB) and have earned a total of 1,075 hits. The St. Louis Cardinals have compiled an on-base percentage of .316 as well as a batting average of .241 so far this year.

The St. Louis pitching staff have allowed 600 runs on the year while holding an ERA of 4.21 (554 earned runs relinquished). They have relinquished 131 long balls and they surrender 4.56 runs per 9 innings (18th in the league). The Cardinals hold a team WHIP of 1.340 and have a FIP of 4.07 as a pitching staff on the year. They have earned a strikeout to walk ratio of 7.80 (1,028 strikeouts vs 448 free passes). They are currently ranked 26th in baseball as a staff in total hits allowed with 1,140.

They sit at 17th in the league holding a save rate of 61.3%, and they have dispatched 445 relief pitchers to the mound this year. Their relievers have come in 165 times in high leverage situations and on 136 occasions with runners on. With 152 save situations, the Cardinals have accumulated 86 holds and 24 blown saves. St. Louis has called on bullpen pitchers to enter the contest in 62 save opportunities and they have tallied 38 saves. St. Louis bullpen pitchers have an inherited score percentage of 39.5% out of their 205 inherited runners.

The St. Louis Cardinals have turned 132 double plays and hold a fielding percentage of .988 (4th in pro baseball). The Cardinals have accrued 1,247 assists, 56 errors and have 3,555 putouts for the season. In 10,665 innings played, the Cardinals have accumulated a efficiency on defense of 69.3% (23rd in baseball).

In his career, Matthews has surrendered 18 hits while totaling 13 strikeouts in 14 frames. He has given up a total of 10 earned runs while earning a WHIP of 1.786 and being the owner of a FIP of 6.3. His K/BB ratio is 1.86 and he has gone up against 66 hitters during his MLB career. Matthews (0-2 career record) has earned a 6.43 earned run average while conceding 11.6 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take St. Louis (+125)

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