Chicago Cubs vs Arizona Diamondbacks Prediction, 8/25/2026 MLB Picks, Best Bets & Odds

Game: Chicago Cubs vs Arizona Diamondbacks

Date: Tuesday, August 25, 2026

Location: Chase Field in Phoenix, AZ

TV: DBACKS.TV

Odds/Point Spread: Chicago (-152) Arizona (+126)

The Arizona Diamondbacks (69-62) are welcoming the Chicago Cubs (75-56) at Chase Field on Tuesday. The moneyline on this contest has Chicago at -152 and Arizona is opening at +126. The over/under is set at 9. The expected starting pitchers will be Clay Holmes and Brandon Pfaadt.

Chicago has a slugging % of .423 and have struck out 1,129 times, while being walked on 558 occasions. They have 645 RBI's as well as 1,125 base knocks on the campaign, and their team batting average sits at .250. The Cubs have compiled 219 doubles as a team and have hit 174 balls out of the park. They are sitting with 684 runs scored while holding a team OBP of .339. As a team, the Chicago Cubs are compiling 5.2 runs per outing, which has them at 1st in MLB.

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Their strikeout to walk ratio is 2.56 and their pitching staff has earned a collective WHIP of 1.26. Cubs pitchers have relinquished 196 home runs and 569 runs (12th in baseball). Chicago has allowed 1,080 base hits (8.3 per 9 innings) as well as 537 earned runs. The Cubs hold a team ERA of 4.12 over the course of the season (15th in the league), and the staff has struck out 1,007 hitters. They have walked 393 opposing hitters and their FIP is 4.68 as a squad so far this year.

The Cubs have sent 423 relief pitchers to the hill on the season. The relievers have inherited 180 base runners on the campaign with 30.6% of those runners ended up crossing the plate. The relief pitchers are sitting with 49 holds so far this year (30th in the league). Cubs relief pitchers have come into the game with runners on base 131 times in addition to having 128 appearances in high leverage situations. They have compiled 29 saves this season and have blown 21 of their 50 save opportunities. The Cubs relievers have a save percentage of 58.0% and stepped onto the hill in 105 save situations.

The Cubs have converted 72.0% of baseballs in play into outs out of 10,548 innings on the diamond, which has them sitting 2nd in professional baseball. The Chicago Cubs have a total of 3,516 putouts over the course of the season, in addition to 1,234 assists and 49 errors. Their fielding percentage is holding steady at .990 which ranks 1st in baseball, and have a total of 100 double plays.

Holmes has taken the mound for 519 frames and has earned 494 punch outs in his pro baseball career. His earned run average is 3.62 (209 ER's allowed) and his career WHIP is 1.297. He has surrendered 449 base hits (7.8 hits per nine innings) with 224 walks. Holmes (37-32 career mark) is the owner of a FIP of 3.57 while he has gone up against 2,231 hitters in the majors.

The Diamondbacks hold a team SLG% of .401 and they earn 4.56 runs per contest (11th in MLB). They have tallied 228 doubles, while taking a walk 443 times and putting up 598 runs. Arizona has accounted for 129 long balls this year to go along with 570 RBIs. They have been called out on strikes on 951 occasions (29th in baseball) and have totaled 1,077 base hits. The Arizona Diamondbacks have accounted for a team OBP of .318 as well as a batting average of .245 for the year.

The Diamondbacks hold a team WHIP of 1.294 and have a FIP of 4.39 as a unit on the campaign. They come in at 22nd in the league as a pitching staff in total hits surrendered with 1,119. The Arizona pitching staff have allowed 589 runs on the season while having a team ERA of 4.19 (541 earned runs relinquished). They currently have a K/BB ratio of 6.90 (892 strikeouts against 386 walks). They have relinquished 153 HR's and they allow 4.56 runs per 9 innings (19th in MLB).

They are ranked 11th in the league with a save rate of 68.1%, and they have dispatched 433 bullpen pitchers onto the field this season. Their bullpen pitchers have stepped onto the mound 138 times in high leverage situations and also on 115 occasions with runners on. Sitting with 121 save situations, the Diamondbacks have earned 73 holds in addition to 15 blown saves. Arizona has had bullpen pitchers enter the game in 47 save chances and they have come away with 32 saves. Arizona bullpen pitchers hold an inherited score rate of 25.3% of 170 inherited runners.

In 10,467 innings on the field, the Diamondbacks have a defensive efficiency of 71.1% (7th in baseball). The Arizona Diamondbacks have turned 116 double plays and have a fielding percentage of .990 (2nd in professional baseball). The Diamondbacks have 1,142 assists, 49 errors and have notched a total of 3,489 putouts so far this season.

During his pro baseball career, Pfaadt has conceded 578 base knocks while he has accumulated 495 punch outs in 552 frames. He has given up 296 ER's while holding a WHIP of 1.280 and being the owner of a FIP of 4.8. He has a K/BB ratio of 3.84 and he has gone up against 2,351 hitters so far in his MLB career. Pfaadt (34-29 career mark) holds a 4.82 earned run average while allowing 9.4 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Chicago (-152)

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