Chicago Cubs vs Arizona Diamondbacks Prediction, 8/26/2026 MLB Picks, Best Bets & Odds

Game: Chicago Cubs vs Arizona Diamondbacks

Date: Wednesday, August 26, 2026

Location: Chase Field in Phoenix, AZ

TV: DBACKS.TV

Odds/Point Spread: Chicago (-144) Arizona (+120)

The Arizona Diamondbacks (69-63) will compete against the Chicago Cubs (76-56) at Chase Field on Wednesday. The moneyline on this game has the Cubs at -144 and the Diamondbacks are sitting at +120. The total comes in at 9. The expected starting pitchers are Matthew Boyd and Eduardo Rodriguez.

Chicago is slugging .424 and have struck out 1,133 times, while drawing a walk on 562 occasions. They have compiled 652 runs batted in in addition to 1,135 hits on the season, and their team batting average comes in at .250. The Cubs have earned 222 two-baggers as a unit and have knocked 176 baseballs out of the stadium. They have racked up 691 runs while holding a team OBP of .339. As a team, the Chicago Cubs are compiling 5.2 runs per game, which is 1st in the league.

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The Cubs hold a team earned run average of 4.09 for the season (13th in the league), and their staff has rung up 1,013 batters. Cubs pitchers have surrendered 196 long balls and 569 runs (11th in the league). Their pitching staff has walked 394 opposing players and their FIP comes in at 4.66 as a unit this season. Chicago has allowed 1,085 hits (8.3 per 9 innings) and also 537 earned runs. They have earned a strikeout to walk ratio of 2.57 and the pitching staff holds a WHIP of 1.25.

The Cubs relievers have earned a save rate of 58.0% and have entered the game in 105 save situations. They have compiled 29 saves over the course of the season and have blown 21 of 50 save chances. The relief pitchers have inherited 180 base runners so far this season with 30.6% of them ended up scoring. Cubs relief pitchers have entered the game with opponents on base 131 times in addition to having 128 appearances in high leverage situations. The Cubs have sent 425 relievers to the mound for the season. The bullpen have recorded 49 holds this season (30th in the league).

The Chicago Cubs have a tally of 3,543 putouts over the course of the season, in addition to 1,246 assists and 49 errors. Their fielding percentage is holding steady at .990 which has them ranked 1st in baseball, and they have turned 100 double plays. The Cubs have turned 72.1% of baseballs in play into outs in their 10,629 innings, ranking them 2nd in professional baseball.

Boyd (68-79 career record) holds a FIP of 4.47 while he has faced 4,995 opposing batters in the major leagues. He has given up 1,138 base knocks (8.7 hits per nine innings) and has had 364 walks. His earned run average is 4.54 (595 ER's allowed) and he has a WHIP of 1.274. Boyd has taken the ball for 1,179 frames and has earned 1,116 strikeouts during his MLB career.

The Diamondbacks hold a team slugging percentage of .399 and they have an average of 4.53 runs per game (12th in the league). They have hit 228 doubles, while walking 444 times as well as scoring 598 runs. Arizona has accumulated 129 home runs so far this season as well as 570 runs batted in. They have been called out on strikes on 957 instances (29th in the league) and have tallied 1,082 base hits. The Arizona Diamondbacks have accounted for an on-base percentage of .317 in addition to a team batting average of .244 this season.

The Arizona pitching staff have allowed 596 runs on the season while having a team ERA of 4.21 (548 earned runs yielded). They have given up 155 homers and they give up 4.58 runs per 9 innings (19th in the league). The Diamondbacks are sitting with a team WHIP of 1.296 and have a FIP of 4.40 as a team on the year. They currently have a strikeout to walk ratio of 6.90 (896 strikeouts against 390 bases on balls). They are currently ranked 23rd in baseball as a staff in total hits conceded with 1,129.

They sit at 11th in the league holding a save percentage of 68.1%, and they have dispatched 436 bullpen pitchers to the mound on the campaign. Their relievers have come in 138 times in high leverage situations and also on 116 occasions with base runners. Sitting with 121 save situations, the Diamondbacks have compiled 73 holds in addition to 15 blown saves. Arizona has had relievers take the mound in 47 save chances and they have tallied 32 saves. Arizona bullpen pitchers hold an inherited score percentage of 25.7% out of their 171 inherited runners.

Out of their 10,548 innings on the diamond, the Diamondbacks have earned a efficiency on defense of 71.1% (7th in baseball). The Arizona Diamondbacks have turned 116 double plays and have earned a fielding percentage of .990 (2nd in pro baseball). The Diamondbacks have accrued 1,150 assists, 49 errors and have earned a total of 3,516 putouts this year.

So far in his career, Rodriguez has allowed 1,418 base hits while he has accumulated 1,407 strikeouts in 1,459 frames. Rodriguez (107-70 win-loss record in his career) is the owner of a 4.02 earned run average and has given up 8.7 hits per 9 innings. He has surrendered a total of 652 earned runs while earning a WHIP of 1.317 and a FIP of 4.0. He has a strikeout to walk ratio of 2.79 and he has faced 6,214 opposing hitters during his career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Arizona (+120)

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