Chicago Cubs vs Chicago White Sox Prediction, 5/15/2026 MLB Picks, Best Bets & Odds

Game: Chicago Cubs vs Chicago White Sox

Date: Friday, May 15, 2026

Location: Rate Field in Chicago, IL

TV: Chicago Sports Network

Odds/Point Spread: Chicago (-128) Chicago (+106)

The Chicago White Sox (21-21) host the Chicago Cubs (27-16) at Rate Field on Friday. The moneyline on this contest has Chicago at -128 while Chicago is priced at +106. The total comes in at 8. The pitchers who are expected to start are Edward Cabrera and Sean Burke.

Chicago is slugging .406 and have been rung up 347 times, while drawing a walk on 201 occasions. They have earned 201 runs batted in as well as 357 hits on the season, and their average at the plate is sitting at .246. The Cubs have hit 65 two-baggers as a team and have knocked 52 balls out of the stadium. They have notched a total of 218 runs while holding a team OBP of .342. As a squad, the Chicago Cubs are putting up 5.1 runs per game, which ranks them 3rd in MLB.

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The Cubs have an ERA of 3.86 this year (11th in the league), and their staff has rung up 349 hitters. Cubs pitchers have conceded 54 long balls in addition to 177 total runs (11th in the league). Their pitching staff has walked 131 opposing batters and their FIP sits at 4.24 as a team so far this season. Chicago has yielded 328 hits (7.7 per 9 innings) as well as 164 earned runs. Their strikeout to walk ratio is 2.66 and their pitching staff holds a WHIP of 1.20.

Cubs bullpen pitchers have entered the game with runners on 44 times in addition to having 41 appearances in high leverage situations. The bullpen have a total of 9 holds on the season (30th in MLB). The Cubs relievers have compiled a save rate of 60.0% and have entered the game in 27 save situations. They have earned 9 saves for the year and have not converted 6 of their 15 save opportunities. The bullpen pitchers have inherited 62 base runners on the year and 30.6% of them ended up crossing the plate. The Cubs have sent 126 relievers to the mound on the campaign.

The Chicago Cubs have 1,146 putouts over the course of the season, as well as 399 assists and 20 errors. Their fielding percentage sits at .987 which has them ranked 15th in the majors, and have 32 double plays. The Cubs have turned 72.3% of balls in play into outs out of their 3,438 innings, which has them ranked 3rd in baseball.

Cabrera (28-30 win-loss mark in his career) has earned a FIP of 3.99 while he has faced 2,036 batters in the major leagues. He has conceded 395 hits (7.4 hits per 9 innings) and has 231 walks. His ERA is 4.05 (215 earned runs allowed) and his career WHIP is 1.312. Cabrera has taken the mound for 477 innings and has tallied 521 K's so far in his pro baseball career.

The Chicago White Sox have accounted for a team on-base percentage of .323 in addition to a team batting average of .233 for the year. They have struck out on 393 occasions (6th in the league) and have earned a total of 321 hits. Chicago has accounted for 55 home runs so far this year to go along with 173 RBIs. The White Sox have a team SLG% of .396 and they have an average of 4.36 runs per outing (14th in the league). They have 49 doubles, while taking a walk 162 times as well as scoring 183 runs.

The White Sox have a WHIP of 1.362 in addition to having a FIP of 4.42 as a squad so far this year. Their K/BB ratio is 8.10 (337 strikeouts against 173 bases on balls). They are currently ranked 13th in the league as a pitching staff in total hits surrendered with 334. They have relinquished 45 homers and they allow 4.72 runs per 9 innings (21st in the league). The Chicago pitching staff have surrendered 195 runs this year while holding a team ERA of 4.28 (177 earned runs given up).

Chicago bullpen pitchers have an inherited score percentage of 30.1% out of their 73 inherited base runners. Their relievers have stepped onto the hill 44 times in high leverage situations and also on 49 occasions with runners on base. Sitting with 40 save situations, the White Sox have earned 16 holds in addition to 10 blown saves. They rank 21st in MLB with a save rate of 58.3%, and they have sent 148 relief pitchers to the mound so far this year.

In 3,354 innings on the diamond, the White Sox are sitting with a defensive efficiency of 70.8% (11th in baseball). The Chicago White Sox have turned 32 double plays and have notched a fielding percentage of .986 (17th in baseball). The White Sox have racked up 384 assists, 21 errors and have 1,118 putouts over the course of the season.

During his pro baseball career, Burke has allowed 181 hits while he has tallied 191 punch outs in 197 innings. He has conceded 84 earned runs while holding a WHIP of 1.324 and having a FIP of 3.8. He has a strikeout to walk ratio of 2.39 and he has faced 851 batters in his career. Burke (8-14 win-loss mark in his career) holds a 3.84 earned run average while surrendering 8.3 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Chicago (+106)

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