Chicago Cubs vs Cincinnati Reds Prediction, 9/19/2026 MLB Picks, Best Bets & Odds

Game: Chicago Cubs vs Cincinnati Reds

Date: Saturday, September 19, 2026

Location: Great American Ball Park in Cincinnati, OH

TV: Reds.TV

Odds/Point Spread: Chicago (-150) Cincinnati (+125)

The Chicago Cubs (85-68) are en route to Great American Ball Park on Saturday where they will meet the Cincinnati Reds (71-82). The moneyline on this game has Chicago at -150 while Cincinnati is sitting at +125. The betting total is set at 9. The pitchers who are expected to start are Matthew Boyd and Nick Lodolo.

Chicago has a slugging percentage of .431 and have been called out on strikes 1,271 times, while drawing a walk on 643 occasions. They have amassed 772 runs batted in and 1,320 base knocks so far this season, and their average at the plate is .252. The Cubs have accrued 261 doubles as a team and have knocked 211 balls out of the stadium. They have accumulated 817 runs scored while holding a team on-base percentage of .340. As a unit, the Chicago Cubs are knocking in 5.3 runs per game, which has them sitting at 1st in MLB.

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The Cubs have an earned run average of 4.19 for the year (17th in MLB), and their staff has rung up 1,188 batters. Cubs pitchers have relinquished 227 long balls and 674 runs (13th in MLB). Their pitching staff has walked 471 players from the other team and their FIP comes in at 4.68 as a unit this year. Chicago has surrendered 1,263 hits (8.3 per 9 innings) as well as 636 earned runs. Their strikeout to walk ratio is 2.52 and the pitching staff has a team WHIP of 1.27.

The Cubs have sent 489 relievers to the hill on the campaign. The bullpen pitchers have inherited 217 runners so far this season with 33.2% of those players crossing home plate. The relievers have recorded 52 holds for the year (30th in MLB). Cubs relief pitchers have entered the contest with runners on 155 times as well as having 146 appearances in high leverage situations. They have earned 33 saves over the course of the season and have blown 27 of their 60 save opportunities. The Cubs relievers have accumulated a save percentage of 55.0% and have entered the game in 119 save situations.

The Cubs have turned 71.8% of balls hit into play into outs out of 12,294 innings on the diamond, which ranks them 3rd in professional baseball. The Chicago Cubs have a tally of 4,098 putouts thus far, as well as 1,448 assists and 56 errors. Their fielding percentage is holding steady at .990 which is 1st in MLB, and they have turned 116 double plays.

Boyd (68-82 record in his career) is the owner of a FIP of 4.47 while going up against 5,088 batters in the majors. He has conceded 1,160 base hits (8.7 hits per 9 innings) and has 371 free passes. His ERA is 4.54 (606 ER's allowed) and his career WHIP is 1.273. Boyd has pitched in 1,202 innings and is sitting with 1,134 K's so far in his MLB career.

The Cincinnati Reds have accumulated an on-base percentage of .307 as well as a team batting average of .230 on the year. They have been rung up on 1,458 occasions (1st in baseball) and have tallied 1,168 base hits. Cincinnati has a total of 203 home runs this year to go along with 605 runs batted in. The Reds hold a slugging percentage of .396 and they tally 4.14 runs per game (26th in baseball). They have recorded 212 doubles, while walking 534 times and notching 633 runs.

The Reds have a team WHIP of 1.450 and are the owners of a FIP of 4.81 as a unit on the campaign. They currently have a K/BB ratio of 8.20 (1,233 strikeouts against 638 walks). They are currently ranked 26th in baseball as a pitching staff in total hits relinquished with 1,325. They have conceded 203 long balls and they concede 5.23 runs per 9 innings (28th in MLB). The Cincinnati pitching staff have conceded 787 runs so far this season while holding an ERA of 4.87 (733 earned runs yielded).

Cincinnati relief pitchers hold an inherited score percentage of 27.1% out of their 240 inherited runners. Their relievers have come in 180 times in high leverage situations and also on 160 occasions with runners on. With 149 save situations, the Reds have 83 holds and also 22 blown saves. They sit at 14th in MLB with a save percentage of 64.5%, and they have dispatched 545 bullpen pitchers onto the diamond for the season.

Out of their 12,186 innings on the diamond, the Reds have accumulated a defensive efficiency of 69.4% (20th in MLB). The Cincinnati Reds have turned 108 double plays and hold a fielding percentage of .984 (20th in professional baseball). The Reds have recorded 1,227 assists, 87 errors and have 4,062 putouts on the season.

So far in his pro baseball career, Lodolo has given up 481 base knocks while totaling 535 strikeouts in 505 innings. He has surrendered 240 ER's while holding a WHIP of 1.266 and being the owner of a FIP of 4.2. He has a K/BB ratio of 3.36 and he has gone up against 2,175 hitters so far in his career. Lodolo (27-27 career mark) has earned a 4.27 earned run average and has allowed 8.6 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Chicago (-150)

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