Chicago Cubs vs Los Angeles Dodgers Prediction, 4/25/2026 MLB Picks, Best Bets & Odds

Game: Chicago Cubs vs Los Angeles Dodgers

Date: Saturday, April 25, 2026

Location: Dodger Stadium in Los Angeles, CA

TV: Spectrum SportsNet LA

Odds/Point Spread: Chicago (+125) Los Angeles (-145)

The Los Angeles Dodgers (17-8) will go up against the Chicago Cubs (16-9) at Dodger Stadium on Saturday. The line on this matchup has the Cubs at +125 while the Dodgers are at -145. The total is set at 8. The starting pitchers are Colin Rea and Roki Sasaki.

Chicago has a slugging % of .427 and have struck out 207 times, while taking a walk on 116 occasions. They have earned 125 runs batted in as well as 230 hits for the year, while their batting average sits at .267. The Cubs have hit 38 doubles as a team and have smacked 32 balls out of the park. They have earned 139 runs and hold an on-base percentage of .357. As a squad, the Chicago Cubs are notching 5.6 runs per game, which is 2nd in baseball.

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The Cubs have compiled a team ERA of 3.44 on the campaign (5th in the league), and their staff has rung up 204 batters. Cubs pitchers have yielded 29 home runs in addition to 96 runs in total (6th in baseball). Their pitching staff has walked 74 opposing players and their FIP is 4.11 as a unit so far this year. Chicago has surrendered 184 base knocks (7.4 per 9 innings) as well as 86 earned runs. Their K/BB ratio is 2.76 and the pitching staff sits with a WHIP of 1.15.

Cubs pitchers have entered the contest with players on base 26 times in addition to having 22 appearances in high leverage situations. The relief pitchers have tallied 4 holds for the year (30th in the league). The Cubs relief pitchers have accumulated a save rate of 44.4% and have come into the game in 13 save situations. They have tallied 4 saves for the year and have blown 5 of their 9 save opportunities. The bullpen pitchers have inherited 33 runners so far this year with 24.2% of those runners ended up scoring. The Cubs have dispatched 77 relievers to the mound on the campaign.

The Cubs have transformed 72.8% of baseballs in play into outs in their 2,025 innings, which ranks them 3rd in professional baseball. The Chicago Cubs have a tally of 675 putouts over the course of the season, in addition to 228 assists and 14 errors. Their fielding rate is holding steady at .985 which is 16th in baseball, and they have turned 20 double plays.

Rea has thrown 630 innings and has racked up 513 punch outs thus far in his career. His earned run average is 4.36 (305 earned runs allowed) and his WHIP is 1.260. He has given up 607 base hits (8.7 hits per nine innings) and has had 187 free passes. Rea (40-27 career record) holds a FIP of 4.29 and he has gone up against 2,663 opposing hitters in the majors.

The Dodgers have a team slugging % of .473 and they average 5.48 runs per game (4th in MLB). They have put up 37 two-baggers, while taking a walk 97 times as well as earning 137 runs. Los Angeles has accumulated 42 home runs on the season as well as 131 RBIs. They have been rung up on 212 occasions (15th in the league) and are sitting with 237 base hits. The Los Angeles Dodgers have an OBP of .355 in addition to a batting average of .279 for the season.

The Los Angeles pitching staff have allowed 82 runs for the year while holding an ERA of 3.27 (80 earned runs yielded). They have surrendered 19 dingers and they concede 3.35 runs per 9 innings (1st in MLB). The Dodgers have a team WHIP of 1.077 in addition to having a FIP of 3.44 as a pitching staff this season. Their K/BB ratio is 8.50 (208 strikeouts vs 71 walks). They are currently ranked 1st in baseball as a pitching staff in total hits allowed with 166.

They rank 15th in MLB with a save percentage of 63.6%, and they have sent 73 relievers onto the diamond on the campaign. Their relievers have stepped onto the mound 24 times in high leverage situations in addition to 14 occasions with runners on. Sitting with 25 save situations, the Dodgers have accumulated 14 holds in addition to 4 blown saves. Los Angeles has had bullpen pitchers enter the game in 11 save opportunities and they have walked away with 7 saves. Los Angeles bullpen pitchers hold an inherited score percentage of 29.2% out of 24 inherited base runners.

The Los Angeles Dodgers have turned 16 double plays and hold a fielding percentage of .992 (3rd in pro baseball). The Dodgers have recorded 209 assists, 7 errors and have accounted for 660 putouts during this campaign. In their 1,980 innings on the field, the Dodgers have earned a efficiency on defense of 73.9% (1st in MLB).

Sasaki (1-3 career win-loss mark) has earned a 5.07 earned run average while conceding 8.6 hits per 9 innings. He has a strikeout to walk ratio of 1.32 and he has gone up against 246 opposing batters so far in his career. He has allowed a total of 30 ER's while holding a WHIP of 1.595 and a FIP of 5.0. In his career, Sasaki has surrendered 51 base knocks while tallying 45 punch outs in 53 innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Los Angeles (-145)

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