Chicago Cubs vs San Diego Padres Prediction, 4/29/2026 MLB Picks, Best Bets & Odds

Game: Chicago Cubs vs San Diego Padres

Date: Wednesday, April 29, 2026

Location: Petco Park in San Diego, CA

TV: Padres.TV

Odds/Point Spread: Chicago (-132) San Diego (+110)

The Chicago Cubs (17-12) are hitting the road to Petco Park on Wednesday where they will take on the San Diego Padres (19-9). The odds on this game have the Cubs at -132 while the Padres are opening at +110. The over/under is set at 9. The pitchers taking the mound will be Jameson Taillon and Matt Waldron.

The Cubs have earned 41 two-baggers as a team and have knocked 39 baseballs out of the park. Chicago is slugging .426 and have struck out 247 times, while drawing a walk on 130 occasions. As a squad, the Chicago Cubs are putting up 5.4 runs per game, which ranks them 3rd in the league. They have recorded 141 runs batted in and 262 hits on the year, and their average at the plate is sitting at .262. They have 156 runs while having a team on-base percentage of .352.

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The Cubs have an ERA of 4.05 on the campaign (13th in the league), and the staff has struck out 233 batters. Cubs pitchers have surrendered 33 home runs in addition to 127 runs in total (13th in baseball). They have walked 89 opposing hitters and their FIP is 4.13 as a team this year. Chicago has given up 225 hits (7.8 per 9 innings) and 116 earned runs. Their strikeout to walk ratio is 2.62 and their pitching staff holds a WHIP of 1.22.

The Cubs have dispatched 86 relievers to the mound on the season. The bullpen pitchers have inherited 39 runners so far this season and 33.3% of those players crossing the plate. The relief pitchers have racked up 4 holds for the season (30th in baseball). Cubs pitchers have entered the game with players on base 30 times and also have had 25 appearances in high leverage situations. They have earned 5 saves this season and have blown 5 of their 10 chances to save the game. The Cubs relief pitchers have earned a save rate of 50.0% and have entered the game in 14 save situations.

The Chicago Cubs have earned 774 putouts on the campaign, in addition to 259 assists and 16 errors. Their fielding percentage is at .985 which has them ranked 17th in pro baseball, and have a total of 20 double plays. The Cubs have turned 71.5% of balls hit into play into outs out of their 2,322 innings, ranking them 5th in baseball.

Taillon has pitched in 1,264 innings and has tallied 1,098 K's in his MLB career. Taillon (83-61 record in his career) has a FIP of 3.83 and he has gone up against 5,244 batters in the majors. His earned run average is 3.89 (546 earned runs allowed) and his career WHIP is 1.196. He has given up 1,206 base hits (8.6 hits per 9 innings) and has 306 free passes.

San Diego has compiled 26 long balls this year to go along with 127 runs batted in. They have hit 54 doubles, while getting a free base 97 times as well as scoring 132 runs. The San Diego Padres have accounted for an OBP of .315 as well as a team batting average of .240 so far this year. The Padres hold a team slugging % of .390 and they average 4.71 runs per contest (13th in baseball). They have struck out on 230 occasions (21st in MLB) and have notched a total of 225 base hits.

The Padres have a WHIP of 1.288 and are the owners of a FIP of 3.56 as a pitching staff for the year. Their strikeout to walk ratio is 9.00 (250 strikeouts against 92 free passes). They come in at 16th in MLB as a staff in total hits relinquished with 230. They have conceded 22 long balls and they surrender 4.25 runs per 9 innings (10th in MLB). The San Diego pitching staff have conceded 118 runs over the course of the season while having a team ERA of 4.07 (113 earned runs allowed).

Sitting with 43 save situations, the Padres have compiled 23 holds and also 6 blown saves. San Diego has called on relievers to enter the contest in 18 save opportunities and they have tallied 12 saves. San Diego relievers have an inherited score percentage of 36.4% of 44 inherited runners. Their relievers have come in 32 times in high leverage situations in addition to 25 occasions with base runners. They are ranked 10th in baseball with a save percentage of 66.7%, and they have dispatched 95 bullpen pitchers onto the diamond so far this year.

The San Diego Padres have turned 23 double plays and own a fielding percentage of .993 (2nd in baseball). The Padres have recorded 247 assists, 7 errors and have amassed 750 putouts so far this season. In 2,250 innings on the field, the Padres have earned a defensive efficiency of 68.8% (22nd in the majors).

Waldron (8-16 career record) holds a 5.21 earned run average while conceding 9.3 hits per 9 innings. He has a strikeout to walk ratio of 2.81 and he has gone up against 870 hitters in his career. He has conceded 116 ER's while holding a WHIP of 1.337 and a FIP of 5.1. In his career, Waldron has allowed 206 hits while tallying 174 K's in 200 innings.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Chicago (-132)

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