Chicago Cubs vs St. Louis Cardinals Prediction, 7/27/2026 MLB Picks, Best Bets & Odds

Game: Chicago Cubs vs St. Louis Cardinals

Date: Monday, July 27, 2026

Location: Busch Stadium in St. Louis, MO

TV: Cardinals.TV

Odds/Point Spread: Chicago (-130) St. Louis (+110)

Busch Stadium is the location where the St. Louis Cardinals (52-51) will attempt to beat the Chicago Cubs (58-45) on Monday. The odds on this game have Chicago at -130 while St. Louis is coming in at +110. The betting total is set at 9. The pitchers taking the mound will be David Peterson and Matthew Liberatore.

As a team, the Chicago Cubs are scoring 5.1 runs per game, which is 4th in baseball. They have a total of 523 runs while having a team on-base percentage of .337. The Cubs have tallied 164 doubles as a team and have hit 129 baseballs out of the park. They have accrued 489 runs batted in and 859 base knocks so far this year, and their team batting average is sitting at .244. Chicago has a slugging percentage of .411 and have struck out 879 times, while being walked on 451 occasions.

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They have a strikeout to walk ratio of 2.56 and their pitching staff holds a collective WHIP of 1.27. Cubs pitchers have given up 157 home runs and also 457 total runs (12th in MLB). Chicago has given up 853 base hits (8.4 per 9 innings) as well as 432 earned runs. The Cubs have an earned run average of 4.23 on the season (16th in the league), and they have struck out 804 hitters. They have walked 314 opposing batters and their FIP is 4.73 as a team on the campaign.

The Cubs bullpen have a save rate of 55.3% and have come into the game in 80 save situations. They have recorded 21 saves on the season and have not converted 17 of 38 save opportunities. The relievers have inherited 152 runners on the campaign with 31.6% of those players ended up crossing the plate. Cubs pitchers have entered the game with runners on 105 times in addition to having 102 appearances in high leverage situations. The Cubs have dispatched 339 relievers to the mound on the season. The relief pitchers have tallied 36 holds so far this season (30th in MLB).

The Chicago Cubs have a total of 2,755 putouts at this point in the season, as well as 955 assists and 40 errors. Their fielding rate is holding at .989 which has them ranked 3rd in MLB, and have 78 double plays. The Cubs have turned 71.7% of balls in play into outs out of their 8,265 innings, which has them sitting at 3rd in pro baseball.

Peterson has thrown 643 innings and has earned 625 strikeouts so far in his career. His earned run average is 4.17 (298 ER's allowed) and he has a career WHIP of 1.371. He has conceded 612 base knocks (8.6 hits per 9 innings) with 270 free passes. Peterson (39-31 win-loss mark in his career) sits with a FIP of 4.11 while going up against 2,758 batters in the major leagues.

St. Louis has accumulated 110 home runs on the campaign to go along with 444 RBIs. They have tallied 138 doubles, while getting a free base 330 times as well as racking up 456 runs. The St. Louis Cardinals have a team OBP of .316 and a batting average of .240 this year. The Cardinals hold a team slugging percentage of .382 and they score 4.43 runs per outing (16th in the league). They have struck out on 797 occasions (27th in the league) and have notched a total of 825 hits.

The St. Louis pitching staff have conceded 462 runs on the season and come in with a team ERA of 4.18 (426 earned runs surrendered). They have surrendered 102 homers and they relinquish 4.53 runs per 9 innings (15th in the league). The Cardinals are sitting with a team WHIP of 1.341 with a FIP of 4.15 as a squad over the course of the season. Their strikeout to walk ratio sits at 7.70 (781 strikeouts against 346 free passes). They have a ranking of 23rd in the league as a pitching staff in total hits given up with 885.

They are ranked 16th in baseball holding a save percentage of 62.0%, and they have dispatched 348 relief pitchers to the mound over the course of the season. Their relief pitchers have stepped onto the mound 122 times in high leverage situations and on 111 occasions with runners on base. Sitting with 122 save situations, the Cardinals have compiled 69 holds and 19 blown saves. St. Louis has had relievers take the mound in 50 save chances and they have tallied 31 saves. St. Louis bullpen pitchers hold an inherited score percentage of 35.6% out of their 163 inherited base runners.

The St. Louis Cardinals have gotten 94 double plays and hold a fielding percentage of .988 (8th in pro baseball). The Cardinals have 961 assists, 46 errors and have earned 2,755 putouts over the course of the season. In their 8,265 innings played, the Cardinals have earned a defensive efficiency of 69.4% (20th in pro baseball).

Thus far in his career, Liberatore has allowed 459 base hits while earning 367 strikeouts in 433 innings pitched. He has surrendered 229 ER's while earning a WHIP of 1.404 and having a FIP of 4.7. He has a strikeout to walk ratio of 2.46 and he has faced 1,879 batters so far in his career. Liberatore (21-31 win-loss mark in his career) has earned a 4.76 ERA and has conceded 9.5 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Chicago (-130)

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