Chicago Cubs vs St. Louis Cardinals Prediction, 7/28/2026 MLB Picks, Best Bets & Odds

Game: Chicago Cubs vs St. Louis Cardinals

Date: Tuesday, July 28, 2026

Location: Busch Stadium in St. Louis, MO

TV: Cardinals.TV

Odds/Point Spread: Chicago (-122) St. Louis (+102)

Busch Stadium is the site where the St. Louis Cardinals (53-52) will try to beat the Chicago Cubs (59-46) on Tuesday. The moneyline on this game has Chicago at -122 while St. Louis is priced at +102. The betting total comes in at 8. The pitchers who are expected to start will be Colin Rea and Hunter Dobbins.

The Cubs have hit 170 two-baggers as a unit and have knocked 131 balls out of the stadium. Chicago is slugging .414 and have struck out 904 times, while drawing a walk on 457 occasions. As a squad, the Chicago Cubs are putting up 5.2 runs/g, which is 3rd in MLB. They have amassed 507 runs batted in as well as 887 base knocks this year, and their batting average is sitting at .247. They have 541 runs while holding a team on-base percentage of .339.

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Their strikeout to walk ratio is 2.58 and their pitching staff holds a WHIP of 1.27. Cubs pitchers have conceded 160 home runs and 465 runs in total (13th in MLB). Chicago has allowed 869 hits (8.4 per 9 innings) and also 440 earned runs. The Cubs have compiled a team earned run average of 4.23 so far this year (18th in MLB), and their staff has struck out 819 hitters. Their pitching staff has walked 318 opposing players and their FIP sits at 4.74 as a team this year.

The Cubs bullpen have recorded a save rate of 56.4% and stepped onto the hill in 81 save situations. They have 22 saves over the course of the season and have blown 17 out of their 39 save opportunities. The relief pitchers have inherited 152 base runners on the campaign and 31.6% of those players crossing home plate. Cubs bullpen pitchers have gone to the mound with players on base 105 times and also have had 102 appearances in high leverage situations. The Cubs have dispatched 343 relievers to the mound over the course of the season. The relief pitchers have recorded 36 holds on the year (30th in the league).

The Cubs have transformed 71.7% of balls hit into play into outs out of their 8,418 innings on the field, which has them ranked 3rd in baseball. The Chicago Cubs have notched a total of 2,806 putouts at this point in the season, in addition to 970 assists and 41 errors. Their fielding percentage sits at .989 which ranks 3rd in professional baseball, and have a total of 80 double plays.

Rea (44-34 career record) has a FIP of 4.41 while he has gone up against 3,028 hitters in the majors. He has given up 699 base hits (8.8 hits per nine innings) and has 220 walks. His ERA is 4.48 (354 ER's allowed) and his WHIP is 1.292. Rea has taken the hill for 711 innings and has 574 strikeouts during his MLB career.

St. Louis has 111 long balls on the season to go along with 454 runs batted in. They have tallied 141 two-baggers, while taking a walk 337 times and racking up 466 runs. The St. Louis Cardinals have recorded a team on-base percentage of .316 and a team batting average of .240 for the year. The Cardinals have a team slugging % of .381 and they are earning 4.44 runs per game (16th in baseball). They have been called out on strikes on 811 occasions (27th in MLB) and have earned a total of 842 base hits.

The Cardinals have a WHIP of 1.334 and are the owners of a FIP of 4.13 as a squad so far this season. Their strikeout to walk ratio comes in at 7.70 (806 strikeouts against 352 bases on balls). They are currently ranked 22nd in baseball as a pitching staff in total hits conceded with 898. They have conceded 104 home runs and they concede 4.49 runs per 9 innings (14th in the league). The St. Louis pitching staff have given up 467 runs this season while having a team ERA of 4.13 (430 earned runs relinquished).

They are ranked 17th in the league holding a save percentage of 62.0%, and they have sent 354 relievers to the mound on the campaign. Their relief pitchers have stepped onto the hill 127 times in high leverage situations and on 113 occasions with base runners. Sitting with 122 save situations, the Cardinals have earned 69 holds and 19 blown saves. St. Louis has called on bullpen pitchers to step onto the mound in 50 save opportunities and they have walked away with 31 saves. St. Louis relief pitchers have an inherited score percentage of 36.4% out of 165 inherited base runners.

In 8,436 innings on the diamond, the Cardinals hold a efficiency on defense of 69.5% (19th in the majors). The St. Louis Cardinals have gotten 95 double plays and hold a fielding percentage of .988 (6th in baseball). The Cardinals have racked up 976 assists, 46 errors and have 2,812 putouts for the season.

Dobbins (6-2 win-loss record in his career) has earned a 3.84 earned run average while giving up 8.9 hits per nine innings. He has a strikeout to walk ratio of 2.70 and he has gone up against 375 batters so far in his pro baseball career. He has allowed a total of 38 earned runs while holding a WHIP of 1.291 and a FIP of 3.8. Thus far in his career, Dobbins has given up 88 hits and he has 73 K's in 89 frames.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take St. Louis (+102)

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