Chicago White Sox vs Arizona Diamondbacks Prediction, 4/21/2026 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs Arizona Diamondbacks

Date: Tuesday, April 21, 2026

Location: Chase Field in Phoenix, AZ

TV: DBACKS.TV

Odds/Point Spread: Chicago (+126) Arizona (-152)

The Arizona Diamondbacks (13-9) are welcoming the Chicago White Sox (8-14) at Chase Field on Tuesday. The line on this matchup has the White Sox at +126 while the Diamondbacks open at -152. The over/under comes in at 9. The pitchers who are expected to start will be Sean Burke and Merrill Kelly.

Chicago has a slugging % of .356 and have been called out on strikes 208 times, while drawing a walk on 85 occasions. They have recorded 74 RBI's as well as 151 hits on the campaign, and their team batting average is sitting at .210. The White Sox have tallied 27 doubles as a team and have hit 24 balls out of the park. They have tallied 82 runs scored while holding a team on-base percentage of .304. As a squad, the Chicago White Sox are putting up 3.7 runs per contest, which puts them at 25th in the league.

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They have earned a K/BB ratio of 1.64 and the pitching staff has earned a collective WHIP of 1.45. White Sox pitchers have surrendered 21 home runs and 113 runs in total (27th in the league). Chicago has allowed 177 base knocks (8.2 per 9 innings) and also 104 earned runs. The White Sox have compiled a team ERA of 4.83 this year (26th in the league), and they have rung up 169 batters. They have walked 103 opposing hitters and their FIP comes in at 4.53 as a squad so far this year.

White Sox pitchers have gone to the mound with players on base 30 times and also have had 26 appearances in high leverage situations. The bullpen have recorded 10 holds over the course of the season (19th in baseball). The White Sox bullpen have recorded a save percentage of 42.9% and have come into the game in 24 save situations. They have accumulated 6 saves for the year and have blown 8 of their 14 chances to get a save. The bullpen pitchers have inherited 50 runners so far this season and 34.0% of those players earned a run for their team. The White Sox have sent 84 relief pitchers to the hill over the course of the season.

The Chicago Cubs are sitting with 581 putouts this year, as well as 194 assists and 14 errors. Their fielding percentage sits at .982 which is 23rd in pro baseball, and have accumulated 14 double plays. The White Sox have converted 70.2% of balls in play into outs out of their 1,743 innings on the field, which ranks them 17th in professional baseball.

Burke has thrown 173 innings and has earned 172 strikeouts in his career. Burke (6-13 career mark) has earned a FIP of 3.89 and he has faced 759 hitters in the majors. His ERA is 3.95 (76 ER's allowed) and he has a WHIP of 1.380. He has given up 163 hits (8.5 hits per nine innings) and has 76 walks.

The Diamondbacks hold a slugging percentage of .399 and they are recording 4.50 runs per game (14th in MLB). They have put up 47 doubles, while walking 51 times as well as recording 99 runs. Arizona has accumulated 18 HRs on the year as well as 96 RBIs. They have struck out on 174 instances (24th in MLB) and have a total of 177 base hits. The Arizona Diamondbacks have earned an OBP of .295 in addition to a batting average of .244 so far this season.

The Diamondbacks have a team WHIP of 1.256 in addition to having a FIP of 4.17 as a team over the course of the season. They are currently ranked 21st in baseball as a pitching staff in total hits conceded with 180. The Arizona pitching staff have yielded 102 runs so far this season while holding an ERA of 4.01 (87 earned runs yielded). Their K/BB ratio is 7.50 (162 strikeouts against 65 walks). They have given up 24 home runs and they relinquish 4.71 runs per 9 innings (20th in the league).

Arizona bullpen pitchers hold an inherited score percentage of 21.4% out of 28 inherited base runners. Their bullpen pitchers have taken the field 39 times in high leverage situations and also on 21 occasions with base runners. Sitting with 37 save situations, the Diamondbacks have amassed 22 holds in addition to 5 blown saves. They rank 14th in baseball with a save rate of 64.3%, and they have dispatched 76 relief pitchers onto the diamond on the year.

Out of their 1,758 innings on the diamond, the Diamondbacks have accumulated a efficiency on defense of 71.3% (8th in professional baseball). The Arizona Diamondbacks have gotten 14 double plays and own a fielding percentage of .986 (15th in professional baseball). The Diamondbacks have 194 assists, 11 errors and have earned 586 putouts for the year.

Thus far in his career, Kelly has allowed 912 hits while he has totaled 914 K's in 1,013 frames. He has given up a total of 424 ER's while earning a WHIP of 1.200 and a FIP of 3.7. His K/BB ratio is 3.01 and he has gone up against 4,167 batters in his career. Kelly (66-53 career win-loss mark) has earned a 3.77 ERA while conceding 8.1 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Arizona (-152)

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