Chicago White Sox vs Arizona Diamondbacks Prediction, 4/22/2026 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs Arizona Diamondbacks

Date: Wednesday, April 22, 2026

Location: Chase Field in Phoenix, AZ

TV: DBACKS.TV

Odds/Point Spread: Chicago (+126) Arizona (-152)

The Chicago White Sox (8-14) are hitting the road to Chase Field on Wednesday where they will meet the Arizona Diamondbacks (13-9). The odds on this game have the White Sox at +126 and the Diamondbacks are opening at -152. The over/under comes in at 8. The pitchers taking the mound are Anthony Kay and Eduardo Rodriguez.

As a team, the Chicago White Sox are notching 3.7 runs per contest, which has them sitting at 25th in baseball. They have a total of 82 runs and hold an OBP of .304. The White Sox have recorded 27 doubles as a team and have hit 24 baseballs out of the park. They have tallied 74 RBI's in addition to 151 hits for the season, while their team batting average is .210. Chicago has a slugging percentage of .356 and have been called out on strikes 208 times, while drawing a walk on 85 occasions.

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The White Sox hold a team ERA of 4.83 so far this year (26th in baseball), and the staff has rung up 169 hitters. White Sox pitchers have allowed 21 home runs and 113 runs in total (24th in the league). They have walked 103 players from the other team and their FIP is 4.53 as a team this season. Chicago has surrendered 177 hits (8.2 per 9 innings) and 104 earned runs. Their strikeout to walk ratio is 1.64 and their pitching staff has earned a collective WHIP of 1.45.

White Sox relief pitchers have gone to the mound with players on base 30 times in addition to having 26 appearances in high leverage situations. The relief pitchers have tallied 10 holds for the season (21st in the league). The White Sox relief pitchers have recorded a save percentage of 42.9% and stepped onto the hill in 24 save situations. They have earned 6 saves this season and have blown 8 of their 14 save chances. The relief pitchers have inherited 50 base runners for the year and 34.0% of them ended up crossing the plate. The White Sox have sent 84 relief pitchers to the mound so far this season.

The White Sox have converted 70.2% of balls in play into outs out of their 1,743 innings, which ranks them 17th in the majors. The Chicago Cubs have accumulated 581 putouts over the course of the season, as well as 194 assists and 14 errors. Their fielding percentage is holding at .982 which ranks 24th in pro baseball, and they have turned 14 double plays.

Kay has pitched in 102 innings and is sitting with 100 punch outs thus far in his career. Kay (5-2 win-loss record in his career) has a FIP of 5.03 while he has faced 471 batters during his time in the majors. His earned run average is 5.11 (58 ER's allowed) and he has a WHIP of 1.556. He has given up 103 base hits (9.1 hits per nine innings) and has had 56 walks.

The Diamondbacks hold a team SLG% of .395 and they are scoring 4.50 runs per outing (14th in the league). They have put up 47 two-baggers, while taking a walk 51 times as well as scoring 99 runs. Arizona has compiled 18 home runs so far this year as well as 94 runs batted in. They have struck out on 174 occasions (25th in MLB) and have totaled 176 hits. The Arizona Diamondbacks have accumulated an on-base percentage of .294 and a team batting average of .242 so far this year.

The Diamondbacks hold a team WHIP of 1.256 in addition to having a FIP of 4.18 as a unit this year. They have earned a strikeout to walk ratio of 7.50 (162 strikeouts against 65 bases on balls). They come in at 19th in the league as a staff in total hits allowed with 180. They have allowed 24 homers and they concede 4.71 runs per 9 innings (19th in MLB). The Arizona pitching staff have allowed 102 runs this year while holding a team ERA of 4.01 (87 earned runs conceded).

With 37 save situations, the Diamondbacks have earned 22 holds and 5 blown saves. Arizona has called on relievers to take the mound in 14 save opportunities and they have earned 9 saves. Arizona relievers have an inherited score percentage of 21.4% of 28 inherited runners. Their bullpen pitchers have taken the field 39 times in high leverage situations in addition to 21 occasions with runners on. They are ranked 13th in MLB holding a save rate of 64.3%, and they have dispatched 76 bullpen pitchers onto the field on the campaign.

The Arizona Diamondbacks have gotten 14 double plays and have a fielding rate of .986 (14th in baseball). The Diamondbacks have accrued 194 assists, 11 errors and have a tally of 586 putouts so far this season. In their 1,758 innings on the diamond, the Diamondbacks are sitting with a defensive efficiency of 71.3% (7th in MLB).

Rodriguez (95-66 mark in his career) has a 4.15 ERA while allowing 8.8 hits per nine innings. His strikeout to walk ratio is 2.83 and he has faced 5,675 opposing hitters so far in his pro baseball career. He has allowed 612 earned runs while holding a WHIP of 1.328 and having a FIP of 4.1. During his MLB career, Rodriguez has conceded 1,299 base hits while he has earned 1,311 punch outs in 1,327 frames.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Arizona (-152)

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