Chicago White Sox vs Boston Red Sox Prediction, 8/5/2026 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs Boston Red Sox

Date: Wednesday, August 5, 2026

Location: Fenway Park in Boston, MA

TV: NESN

Odds/Point Spread: Chicago (+132) Boston (-160)

The Chicago White Sox (59-52) are en route to Fenway Park on Wednesday where they will play the Boston Red Sox (60-51). The moneyline on this game has Chicago at +132 and Boston is opening at -160. The over/under is 8. The expected starting pitchers will be Sean Burke and Sonny Gray.

Chicago has a slugging rate of .408 and have struck out 1,002 times, while drawing a walk on 372 occasions. They have 507 RBI's in addition to 886 base knocks so far this year, while their batting average sits at .238. The White Sox have accumulated 171 doubles as a squad and have hit 146 balls out of the park. They have accumulated 531 runs scored and have an on-base percentage of .316. As a team, the Chicago White Sox are earning 4.8 runs per contest, which is 8th in MLB.

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They have a K/BB ratio of 2.35 and the pitching staff has a team WHIP of 1.29. White Sox pitchers have relinquished 117 home runs in addition to 476 total runs (10th in the league). Chicago has surrendered 873 base knocks (8.0 per 9 innings) in addition to 439 earned runs. The White Sox are sitting with a team earned run average of 4.00 over the course of the season (10th in the league), and the staff has struck out 946 hitters. They have walked 402 hitters and their FIP sits at 4.14 as a team for the season.

White Sox relief pitchers have stepped onto the hill with runners on 117 times and also have had 112 appearances in high leverage situations. The relief pitchers have accumulated 39 holds on the season (30th in the league). The White Sox relievers have accumulated a save rate of 58.3% and have stepped onto the mound in 87 save situations. They have recorded 28 saves this season and have blown 20 of 48 chances to get a save. The relief pitchers have inherited 170 base runners for the year and 32.9% of them earned a run for their team. The White Sox have dispatched 373 relievers to the hill on the year.

The White Sox have converted 70.5% of balls in play into outs in their 8,892 innings on the diamond, ranking them 12th in baseball. The Chicago White Sox have amassed 2,964 putouts over the course of the season, as well as 911 assists and 61 errors. Their fielding rate is holding steady at .985 which ranks 20th in baseball, and they have turned 78 double plays.

Burke has taken the hill for 277 innings and has accounted for 295 punch outs so far in his pro baseball career. His ERA is 3.51 (108 ER's allowed) and his career WHIP is 1.263. He has conceded 243 base knocks (7.9 hits per 9 innings) with 107 walks. Burke (13-16 career record) has a FIP of 3.45 while he has faced 1,177 hitters during his time in the majors.

The Boston Red Sox are sitting with an OBP of .316 and a team batting average of .244 for the year. They have been called out on strikes on 916 instances (21st in the league) and have 903 base hits. Boston has hit 111 long balls so far this year and 452 RBIs. The Red Sox have a SLG% of .396 and they average 4.27 runs per contest (20th in MLB). They have put up 192 two-baggers, while getting a free base 336 times and scoring 474 runs.

The Red Sox have a team WHIP of 1.227 with a FIP of 3.72 as a unit for the season. They currently have a strikeout to walk ratio of 8.60 (943 strikeouts vs 311 free passes). They come in at 11th in the league as a pitching staff in total hits conceded with 898. They have allowed 111 long balls and they give up 3.78 runs per 9 innings (1st in baseball). The Boston pitching staff have conceded 414 runs this season while holding a team ERA of 3.54 (387 earned runs relinquished).

They sit at 2nd in MLB holding a save percentage of 76.2%, and they have sent 344 relievers to the hill this season. Their bullpen pitchers have stepped onto the mound 99 times in high leverage situations and on 88 occasions with base runners. With 115 save situations, the Red Sox have compiled 71 holds and 10 blown saves. Boston has called on relievers to enter the contest in 42 save chances and they have come away with 32 saves. Boston relievers have an inherited score percentage of 29.8% of 124 inherited base runners.

The Boston Red Sox have gotten 78 double plays and hold a fielding percentage of .987 (12th in professional baseball). The Red Sox have racked up 960 assists, 52 errors and have notched a total of 2,956 putouts during this campaign. In their 8,868 innings played, the Red Sox have a defensive efficiency of 69.7% (17th in professional baseball).

In his MLB career, Gray has allowed 1,778 hits and he has 2,023 K's in 2,031 frames. He has given up a total of 800 earned runs while earning a WHIP of 1.196 and a FIP of 3.5. His K/BB ratio is 3.11 and he has gone up against 8,413 opposing hitters in his career. Gray (138-104 career record) holds a 3.54 earned run average and has conceded 7.9 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Boston (-160)

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