Chicago White Sox vs Chicago Cubs Prediction, 8/19/2026 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs Chicago Cubs

Date: Wednesday, August 19, 2026

Location: Wrigley Field in Chicago, IL

TV: Marquee

Odds/Point Spread: Chicago (+106) Chicago (-128)

The Chicago Cubs (72-53) are welcoming the Chicago White Sox (65-58) at Wrigley Field on Wednesday. The odds on this game have Chicago at +106 while Chicago is opening at -128. The betting total is set at 9. The pitchers who are expected to start will be Jose Urquidy and Clay Holmes.

The White Sox have accrued 198 two-baggers as a team and have hit 164 baseballs out of the stadium. Chicago has a slugging % of .412 and have struck out 1,121 times, while being walked on 420 occasions. As a squad, the Chicago White Sox are scoring 4.8 runs/g, which puts them at 7th in baseball. They have tallied 567 runs batted in and 993 hits on the year, and their average at the plate is .240. They have earned 594 runs and have an on-base percentage of .318.

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They have a K/BB ratio of 2.34 and their pitching staff holds a WHIP of 1.29. White Sox pitchers have surrendered 135 home runs and 547 runs in total (14th in MLB). Chicago has relinquished 978 base knocks (8.0 per 9 innings) and 501 earned runs. The White Sox hold a team ERA of 4.11 this year (16th in MLB), and their staff has struck out 1,038 hitters. Their pitching staff has walked 444 players from the other team and their FIP is 4.20 as a unit for the season.

The White Sox relievers have recorded a save rate of 58.2% and have entered the game in 108 save situations. They have recorded 32 saves this year and have blown 23 of 55 chances to save the game. The bullpen pitchers have inherited 193 base runners for the year with 32.1% of them ended up scoring. White Sox pitchers have stepped onto the hill with players on base 134 times and also have had 125 appearances in high leverage situations. The White Sox have dispatched 416 relief pitchers to the mound on the campaign. The relief pitchers have tallied 52 holds on the year (25th in MLB).

The White Sox have turned 70.6% of baseballs in play into outs out of their 9,885 innings, ranking them 11th in professional baseball. The Chicago White Sox have a total of 3,295 putouts this season, in addition to 1,010 assists and 66 errors. Their fielding percentage is holding at .985 which has them sitting 18th in pro baseball, and have a total of 85 double plays.

Urquidy has taken the mound for 410 innings and has earned 332 strikeouts during his MLB career. Urquidy (28-16 record in his career) sits with a FIP of 3.98 while going up against 1,692 opposing hitters during his time in the majors. His ERA is 4.04 (184 ER's allowed) and he has a WHIP of 1.158. He has allowed 375 base hits (8.2 hits per 9 innings) and has 100 walks.

Chicago has hit 159 home runs over the course of the season to go along with 607 RBIs. They have 209 doubles, while getting a free base 531 times and earning 645 runs. The Chicago Cubs have a team on-base percentage of .337 as well as a team batting average of .248 on the campaign. The Cubs have a team slugging % of .417 and they are scoring 5.16 runs per contest (2nd in the league). They have struck out on 1,075 occasions (7th in baseball) and have recorded 1,065 hits.

The Cubs hold a team WHIP of 1.256 in addition to having a FIP of 4.69 as a squad on the campaign. They sit at 20th in MLB as a staff in total hits relinquished with 1,034. The Chicago pitching staff have given up 545 runs so far this year while holding a team ERA of 4.16 (516 earned runs yielded). They currently have a K/BB ratio of 7.70 (956 strikeouts against 368 free passes). They have relinquished 189 HR's and they surrender 4.39 runs per 9 innings (12th in the league).

Sitting with 100 save situations, the Cubs have accrued 46 holds in addition to 19 blown saves. Chicago has called on bullpen pitchers to enter the game in 48 save chances and they have come away with 29 saves. Chicago bullpen pitchers hold an inherited score percentage of 31.8% out of 173 inherited base runners. Their relievers have come in 119 times in high leverage situations in addition to 123 occasions with base runners. They are ranked 20th in baseball with a save percentage of 60.4%, and they have sent 401 relief pitchers to the mound on the season.

In 10,050 innings on the diamond, the Cubs are sitting with a efficiency on defense of 72.0% (3rd in the majors). The Chicago Cubs have gotten 96 double plays and have earned a fielding percentage of .990 (2nd in the majors). The Cubs have accrued 1,167 assists, 46 errors and have accumulated 3,350 putouts on the season.

Holmes (37-31 mark in his career) is the owner of a 3.65 ERA while surrendering 7.8 hits per 9 innings. He has a strikeout to walk ratio of 2.22 and he has gone up against 2,208 batters so far in his pro baseball career. He has allowed a total of 208 earned runs while holding a WHIP of 1.296 and being the owner of a FIP of 3.6. During his pro baseball career, Holmes has allowed 443 base hits while tallying 493 strikeouts in 513 frames.

Who will win tonight's MLB game against the spread or moneyline?

Parlay's Pundit's Pick: Take Chicago (-128) and under 9 runs

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