Chicago White Sox vs Cleveland Guardians Prediction, 10/10/2026 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs Cleveland Guardians

Date: Saturday, October 10, 2026

Location: Progressive Field in Cleveland, OH

TV: TBS

Odds/Point Spread: Chicago (+114) Cleveland (-138)

Progressive Field is the site where the Cleveland Guardians (85-77) will take on the Chicago White Sox (84-78) on Saturday in Game 5 of the ALDS. The series is tied 2-2. The moneyline on this contest has Chicago at +114 while Cleveland is at -138. The over/under is set at 7. The pitchers taking the mound will be Sean Burke and Gavin Williams.

Chicago has a slugging rate of .406 and have struck out 1,494 times, while being walked on 589 occasions. They have accrued 740 RBI's as well as 1,282 hits for the year, while their batting average is sitting at .236. The White Sox have hit 252 doubles as a unit and have hit 211 balls out of the park. They have tallied 776 runs scored and hold an on-base percentage of .320. As a team, the Chicago White Sox are scoring 4.8 runs per game, which has them sitting at 5th in the league.

Get all of our Free MLB Picks

They have accrued a K/BB ratio of 2.34 and their pitching staff holds a WHIP of 1.31. White Sox pitchers have relinquished 180 home runs and also 720 runs in total (15th in baseball). Chicago has surrendered 1,317 base knocks (8.2 per 9 innings) and 660 earned runs. The White Sox have a team ERA of 4.12 for the season (15th in baseball), and the staff has struck out 1,337 hitters. Their pitching staff has walked 571 hitters and their FIP sits at 4.25 as a team this season.

The White Sox relief pitchers have earned a save percentage of 57.7% and have entered the game in 137 save situations. They have recorded 41 saves so far this season and have not converted 30 of their 71 chances to save the game. The relievers have inherited 269 base runners for the year and 30.5% of those players earned a run for their team. White Sox pitchers have stepped onto the hill with players on base 183 times in addition to having 156 appearances in high leverage situations. The White Sox have sent 541 relievers to the hill this year. The bullpen have racked up 63 holds this season (28th in the league).

The White Sox have converted 70.2% of balls hit into play into outs out of their 12,966 innings on the diamond, which has them sitting at 12th in baseball. The Chicago White Sox are sitting with 4,322 putouts this year, in addition to 1,318 assists and 82 errors. Their fielding rate is holding at .986 which has them sitting 16th in the majors, and have a total of 115 double plays.

Burke (17-18 career record) has a FIP of 3.54 and he has faced 1,388 batters in the majors. He has surrendered 287 base knocks (7.9 hits per 9 innings) with 132 walks. His ERA is 3.60 (130 ER's allowed) and his career WHIP is 1.288. Burke has taken the hill for 325 innings and has earned 340 strikeouts during his career.

Cleveland has tallied 162 home runs on the campaign to go along with 650 RBIs. They have put up 249 two-baggers, while getting a free base 574 times and putting up 678 runs. The Cleveland Guardians have recorded a team OBP of .316 and a batting average of .239 on the year. The Guardians hold a team SLG% of .380 and they earn 4.19 runs per game (24th in baseball). They have been called out on strikes on 1,271 instances (26th in the league) and have notched a total of 1,291 hits.

The Cleveland pitching staff have given up 667 runs on the year while having a team ERA of 3.77 (602 earned runs surrendered). They have surrendered 175 homers and they allow 4.18 runs per 9 innings (8th in the league). The Guardians hold a team WHIP of 1.264 and are the owners of a FIP of 3.82 as a squad for the year. Their K/BB ratio is 9.60 (1,530 strikeouts against 530 bases on balls). They are currently ranked 10th in baseball as a staff in total hits surrendered with 1,286.

Cleveland bullpen pitchers hold an inherited score rate of 28.4% out of their 261 inherited runners. Their relief pitchers have come in 178 times in high leverage situations in addition to 166 occasions with runners on. With 183 save situations, the Guardians have accrued 117 holds in addition to 18 blown saves. They rank 6th in MLB holding a save rate of 71.9%, and they have sent 555 relievers to the mound on the season.

In their 12,939 innings on the field, the Guardians are sitting with a defensive efficiency of 69.1% (23rd in the majors). The Cleveland Guardians have gotten 108 double plays and own a fielding percentage of .985 (17th in the majors). The Guardians have accrued 1,262 assists, 86 errors and have 4,313 putouts so far this year.

Williams (32-28 win-loss record in his career) holds a 3.62 ERA while surrendering 7.3 hits per nine innings. He has a strikeout to walk ratio of 2.73 and he has gone up against 2,127 batters so far in his pro baseball career. He has conceded 205 earned runs while holding a WHIP of 1.227 and being the owner of a FIP of 3.6. During his career, Williams has surrendered 412 hits while he has accumulated 581 punch outs in 509 innings.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Chicago (+114)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get MLB picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.