Chicago White Sox vs Cleveland Guardians Prediction, 9/16/2026 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs Cleveland Guardians

Date: Wednesday, September 16, 2026

Location: Progressive Field in Cleveland, OH

TV: MLB.TV

Odds/Point Spread: Chicago (+106) Cleveland (-128)

The Chicago White Sox (77-73) are en route to Progressive Field on Wednesday where they will try to defeat the Cleveland Guardians (76-75). The moneyline on this game has the White Sox at +106 and the Guardians are at -128. The over/under comes in at 8. The starting pitchers will be Erick Fedde and Parker Messick.

Chicago has a slugging % of .403 and have struck out 1,380 times, while taking a walk on 545 occasions. They have accrued 669 runs batted in and 1,180 base knocks so far this year, while their batting average is at .235. The White Sox have accrued 235 doubles as a team and have smacked 194 balls out of the stadium. They are sitting with 702 runs scored while holding a team on-base percentage of .319. As a unit, the Chicago White Sox are notching 4.7 runs per outing, which is 7th in baseball.

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The White Sox are sitting with a team ERA of 4.11 on the season (13th in MLB), and they have rung up 1,240 batters. White Sox pitchers have conceded 166 home runs in addition to 664 runs (13th in MLB). Their pitching staff has walked 531 opposing hitters and their FIP is 4.24 as a squad on the campaign. Chicago has yielded 1,213 base knocks (8.2 per 9 innings) in addition to 609 earned runs. They have a strikeout to walk ratio of 2.34 and their pitching staff has earned a collective WHIP of 1.31.

The White Sox have sent 497 relievers to the hill this season. The relievers have inherited 242 runners so far this season with 31.0% of those players ended up crossing the plate. The bullpen have a total of 55 holds so far this year (29th in the league). White Sox relief pitchers have entered the contest with runners on 165 times as well as having 146 appearances in high leverage situations. They have compiled 38 saves on the year and have blown 27 of their 65 save opportunities. The White Sox relief pitchers have accumulated a save rate of 58.5% and stepped onto the hill in 123 save situations.

The White Sox have turned 70.3% of balls hit into play into outs in their 12,015 innings, which ranks them 12th in professional baseball. The Chicago White Sox have a total of 4,005 putouts on the year, as well as 1,222 assists and 78 errors. Their fielding percentage is holding steady at .985 which puts them in 17th in professional baseball, and they have turned 105 double plays.

Fedde has thrown 905 innings and is sitting with 680 K's during his pro baseball career. Fedde (42-64 career mark) has earned a FIP of 4.73 and he has gone up against 3,933 opposing hitters in the majors. His earned run average is 4.80 (483 ER's allowed) and his WHIP is 1.426. He has given up 933 hits (9.3 hits per nine innings) and has had 358 free passes.

The Cleveland Guardians have compiled an OBP of .314 and a batting average of .237 this season. They have been called out on strikes on 1,204 occasions (23rd in the league) and have tallied 1,193 base hits. Cleveland has recorded 143 home runs so far this year to go along with 592 RBIs. The Guardians have a team slugging percentage of .374 and they are earning 4.09 runs per contest (27th in MLB). They have tallied 232 two-baggers, while getting a free base 532 times and scoring 618 runs.

The Guardians have a team WHIP of 1.262 and have a FIP of 3.85 as a staff for the season. Their strikeout to walk ratio is 9.60 (1,429 strikeouts vs 497 bases on balls). They rank 11th in the league as a staff in total hits surrendered with 1,195. They have given up 166 homers and they allow 4.22 runs per 9 innings (8th in MLB). The Cleveland pitching staff have given up 629 runs on the campaign while holding a team ERA of 3.79 (564 earned runs relinquished).

They rank 5th in the league holding a save percentage of 73.2%, and they have sent 516 relievers onto the diamond this season. Their bullpen pitchers have stepped onto the hill 161 times in high leverage situations and also on 156 occasions with runners on. With 161 save situations, the Guardians have tallied 103 holds and 15 blown saves. Cleveland has called on bullpen pitchers to take the mound in 56 save chances and they have recorded 41 saves. Cleveland relief pitchers have an inherited score percentage of 28.0% of 246 inherited base runners.

The Cleveland Guardians have turned 97 double plays and have accounted for a fielding rate of .985 (18th in baseball). The Guardians have accrued 1,163 assists, 80 errors and have notched a total of 4,022 putouts for the year. In their 12,066 innings on the field, the Guardians have earned a defensive efficiency of 69.3% (22nd in baseball).

Messick (14-10 win-loss record in his career) holds a 2.56 earned run average and has given up 7.5 hits per nine innings. He has a strikeout to walk ratio of 4.08 and he has gone up against 850 opposing hitters so far in his MLB career. He has allowed a total of 60 ER's while earning a WHIP of 1.088 and a FIP of 2.5. During his pro baseball career, Messick has conceded 177 base knocks while accumulating 216 strikeouts in 211 frames.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Chicago (+106)

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