Chicago White Sox vs Kansas City Royals Prediction, 9/22/2026 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs Kansas City Royals

Date: Tuesday, September 22, 2026

Location: Kauffman Stadium in Kansas City, MO

TV: MLB.TV

Odds/Point Spread: Chicago (-150) Kansas City (+125)

Kauffman Stadium is the location where the Kansas City Royals (67-89) will attempt to beat the Chicago White Sox (80-76) on Tuesday. The moneyline on this contest has Chicago at -150 and Kansas City is priced at +125. The betting total comes in at 8. The men taking the mound are Anthony Kay and Daniel Lynch IV.

Chicago has a slugging rate of .402 and have been rung up 1,442 times, while taking a walk on 571 occasions. They have amassed 698 RBI's as well as 1,222 base knocks so far this year, while their average at the plate is at .234. The White Sox have recorded 243 two-baggers as a unit and have smacked 199 baseballs out of the park. They have accumulated 733 runs scored while holding a team OBP of .319. As a squad, the Chicago White Sox are putting up 4.7 runs per game, which has them at 6th in the league.

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The White Sox are sitting with a team earned run average of 4.11 for the season (13th in the league), and their staff has rung up 1,286 hitters. White Sox pitchers have relinquished 172 home runs and also 691 runs in total (15th in MLB). They have walked 558 batters and their FIP comes in at 4.25 as a team this season. Chicago has conceded 1,264 base knocks (8.2 per 9 innings) in addition to 633 earned runs. They have a strikeout to walk ratio of 2.30 and their pitching staff holds a collective WHIP of 1.31.

White Sox pitchers have entered the contest with players on base 175 times and also have had 154 appearances in high leverage situations. The relievers are sitting with 60 holds this season (28th in MLB). The White Sox bullpen have a save percentage of 57.1% and have entered the game in 133 save situations. They have recorded 40 saves for the year and have blown 30 out of their 70 save chances. The bullpen pitchers have inherited 258 runners over the course of the season with 30.2% of those runners crossing the plate. The White Sox have sent 519 relief pitchers to the hill so far this year.

The White Sox have turned 70.3% of balls in play into outs in their 12,489 innings on the diamond, which ranks them 12th in pro baseball. The Chicago White Sox have accumulated 4,163 putouts at this point in the season, as well as 1,270 assists and 80 errors. Their fielding percentage is at .985 which has them sitting 16th in professional baseball, and have accumulated 109 double plays.

Kay has taken the hill for 234 innings and has 209 punch outs during his pro baseball career. His earned run average is 4.84 (126 ER's allowed) and he has a career WHIP of 1.448. He has conceded 239 base knocks (9.2 hits per nine innings) with 100 walks. Kay (13-11 career win-loss mark) is the owner of a FIP of 4.77 while going up against 1,062 batters in the major leagues.

The Royals hold a team slugging % of .398 and they are recording 4.21 runs per outing (23rd in MLB). They have 276 doubles, while walking 497 times and putting up 656 runs. Kansas City has a total of 162 home runs this season to go along with 624 runs batted in. They have been called out on strikes on 1,229 occasions (26th in MLB) and have notched a total of 1,281 hits. The Kansas City Royals have compiled a team on-base percentage of .315 and a batting average of .245 for the year.

The Kansas City pitching staff have allowed 758 runs so far this season while holding a team ERA of 4.66 (710 earned runs allowed). They have given up 196 home runs and they allow 4.98 runs per 9 innings (25th in MLB). The Royals have a team WHIP of 1.393 in addition to having a FIP of 4.66 as a staff on the season. They have earned a strikeout to walk ratio of 7.40 (1,130 strikeouts vs 551 walks). They have a ranking of 28th in MLB as a staff in total hits conceded with 1,358.

Kansas City relief pitchers hold an inherited score rate of 38.5% of 161 inherited base runners. Their relief pitchers have stepped onto the mound 157 times in high leverage situations and on 112 occasions with runners on base. Sitting with 147 save situations, the Royals have compiled 82 holds and also 26 blown saves. They are ranked 21st in baseball with a save rate of 58.1%, and they have dispatched 509 relievers onto the diamond for the season.

The Kansas City Royals have gotten 137 double plays and have a fielding rate of .987 (8th in pro baseball). The Royals have accrued 1,409 assists, 71 errors and have a tally of 4,111 putouts on the season. In their 12,333 innings played, the Royals have earned a defensive efficiency of 69.6% (16th in professional baseball).

Lynch IV (25-30 career win-loss mark) is the owner of a 4.34 earned run average and has given up 9.0 hits per 9 innings. His K/BB ratio is 2.14 and he has faced 1,909 hitters so far in his pro baseball career. He has given up a total of 212 ER's while earning a WHIP of 1.368 and a FIP of 4.3. So far in his pro baseball career, Lynch IV has allowed 439 hits while he has earned 347 K's in 439 frames.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Kansas City (+125)

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