Chicago White Sox vs Kansas City Royals Prediction, 9/23/2026 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs Kansas City Royals

Date: Wednesday, September 23, 2026

Location: Kauffman Stadium in Kansas City, MO

TV: MLB.TV

Odds/Point Spread: Chicago (-122) Kansas City (+102)

The Kansas City Royals (67-89) will take on the Chicago White Sox (80-76) at Kauffman Stadium on Wednesday. The odds on this game have the White Sox at -122 while the Royals are coming in at +102. The over/under is 9. The starting pitchers will be Erick Fedde and Seth Lugo.

Chicago has a slugging rate of .402 and have been called out on strikes 1,442 times, while being walked on 571 occasions. They have recorded 698 runs batted in as well as 1,222 base knocks this season, and their average at the plate is .234. The White Sox have accounted for 243 doubles as a team and have hit 199 baseballs out of the park. They have racked up 733 runs and hold an on-base percentage of .319. As a squad, the Chicago White Sox are notching 4.7 runs per outing, which puts them at 6th in the league.

Get all of our MLB Expert Picks

The White Sox have compiled a team ERA of 4.11 this season (14th in the league), and the staff has struck out 1,286 batters. White Sox pitchers have allowed 172 long balls in addition to 691 runs in total (15th in baseball). Their pitching staff has walked 558 batters and their FIP sits at 4.25 as a squad for the year. Chicago has conceded 1,264 hits (8.2 per 9 innings) and 633 earned runs. They have accumulated a K/BB ratio of 2.30 and the pitching staff has recorded a WHIP of 1.31.

White Sox relief pitchers have entered the game with runners on 175 times in addition to having 154 appearances in high leverage situations. The relief pitchers have 60 holds this year (28th in MLB). The White Sox relief pitchers have a save percentage of 57.1% and stepped onto the hill in 133 save situations. They have recorded 40 saves this year and have not converted 30 of their 70 chances to save the game. The relievers have inherited 258 runners this year with 30.2% of them crossing home plate. The White Sox have sent 519 relief pitchers to the hill so far this year.

The Chicago White Sox have a total of 4,163 putouts over the course of the season, as well as 1,270 assists and 80 errors. Their fielding percentage sits at .985 which ranks 16th in the majors, and they have turned 109 double plays. The White Sox have turned 70.3% of balls hit into play into outs in their 12,489 innings on the diamond, ranking them 12th in pro baseball.

Fedde has pitched in 910 innings and is sitting with 686 K's in his pro baseball career. Fedde (42-64 win-loss record in his career) is the owner of a FIP of 4.71 and he has gone up against 3,954 opposing hitters during his time in the majors. His ERA is 4.79 (484 earned runs allowed) and he has a WHIP of 1.425. He has conceded 937 base knocks (9.3 hits per 9 innings) and has had 360 free passes.

The Royals have a team slugging percentage of .398 and they have an average of 4.21 runs per outing (23rd in MLB). They have recorded 276 doubles, while walking 497 times and putting up 656 runs. Kansas City has hit 162 home runs so far this year as well as 624 runs batted in. They have struck out on 1,229 instances (26th in the league) and have earned a total of 1,281 hits. The Kansas City Royals have compiled a team OBP of .315 in addition to a team batting average of .245 on the year.

The Royals have a team WHIP of 1.393 in addition to having a FIP of 4.66 as a pitching staff on the campaign. They come in at 28th in baseball as a pitching staff in total hits surrendered with 1,358. The Kansas City pitching staff have surrendered 758 runs for the year while holding an ERA of 4.66 (710 earned runs conceded). They currently have a K/BB ratio of 7.40 (1,130 strikeouts vs 551 free passes). They have allowed 196 homers and they relinquish 4.98 runs per 9 innings (25th in MLB).

Kansas City relievers have an inherited score rate of 38.5% out of 161 inherited runners. Their relievers have taken the field 157 times in high leverage situations in addition to 112 occasions with base runners. Sitting with 147 save situations, the Royals have earned 82 holds in addition to 26 blown saves. They are ranked 21st in MLB with a save percentage of 58.1%, and they have dispatched 509 bullpen pitchers to the mound over the course of the season.

The Kansas City Royals have gotten 137 double plays and have a fielding rate of .987 (8th in MLB). The Royals have accrued 1,409 assists, 71 errors and have a tally of 4,111 putouts for the season. In their 12,333 innings on the diamond, the Royals have accumulated a defensive efficiency of 69.6% (16th in professional baseball).

So far in his MLB career, Lugo has given up 1,082 base hits while tallying 1,085 punch outs in 1,162 frames. He has given up 480 earned runs while holding a WHIP of 1.215 and being the owner of a FIP of 3.7. He has a K/BB ratio of 3.29 and he has faced 4,830 opposing batters thus far in his career. Lugo (71-56 career mark) has earned a 3.72 earned run average and has conceded 8.4 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Chicago (-122)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get MLB picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.