Chicago White Sox vs San Diego Padres Prediction, 5/1/2026 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs San Diego Padres

Date: Friday, May 1, 2026

Location: Petco Park in San Diego, CA

TV: Padres.TV

Odds/Point Spread: Chicago (+162) San Diego (-196)

The Chicago White Sox (14-17) are headed to Petco Park on Friday where they will try to beat the San Diego Padres (19-11). The line on this matchup has Chicago at +162 while San Diego is coming in at -196. The over/under has been set at 8. The pitchers who are expected to start are Noah Schultz and German Marquez.

As a unit, the Chicago White Sox are recording 4.2 runs per outing, which has them sitting at 22nd in the league. They have a total of 129 runs scored while having a team OBP of .319. The White Sox have hit 33 doubles as a squad and have hit 38 baseballs out of the stadium. They have earned 119 RBI's and 230 base knocks on the year, while their team batting average is sitting at .225. Chicago has a slugging percentage of .380 and have been called out on strikes 290 times, while drawing a walk on 123 occasions.

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The White Sox hold a team ERA of 4.49 on the year (23rd in baseball), and they have struck out 246 hitters. White Sox pitchers have yielded 32 home runs and 153 runs in total (25th in MLB). They have walked 138 hitters and their FIP comes in at 4.47 as a squad this year. Chicago has relinquished 254 hits (8.3 per 9 innings) as well as 138 earned runs. Their strikeout to walk ratio sits at 1.78 and the pitching staff sits with a WHIP of 1.42.

White Sox pitchers have gone to the mound with runners on 42 times in addition to having 36 appearances in high leverage situations. The relievers have earned 13 holds on the campaign (26th in MLB). The White Sox relief pitchers have a save percentage of 52.6% and have come into the game in 32 save situations. They have recorded 10 saves on the season and have blown 9 of 19 chances to save the game. The bullpen pitchers have inherited 62 base runners on the campaign and 29.0% of those players crossing the plate. The White Sox have dispatched 114 relief pitchers to the hill over the course of the season.

The Chicago White Sox have earned 830 putouts thus far, as well as 278 assists and 17 errors. Their fielding percentage is at .985 which has them ranked 18th in pro baseball, and they have turned 24 double plays. The White Sox have converted 70.2% of balls hit into play into outs in their 2,490 innings on the diamond, which has them sitting 13th in pro baseball.

Schultz (1-1 career win-loss mark) holds a FIP of 3.52 while he has gone up against 63 opposing hitters during his time in the majors. He has conceded 8 base hits (4.8 hits per nine innings) and has had 9 walks. His ERA is 3.58 (6 ER's allowed) and his WHIP is 1.126. Schultz has taken the mound for 15 innings and has earned 18 K's thus far in his career.

The San Diego Padres have accumulated an OBP of .309 as well as a batting average of .235 over the course of the season. They have been rung up on 248 occasions (21st in MLB) and have a total of 234 base knocks. San Diego has accounted for 29 home runs this year to go along with 134 RBIs. The Padres have a team SLG% of .384 and they are scoring 4.63 runs per contest (13th in baseball). They have 54 doubles, while getting a free base 102 times as well as recording 139 runs.

The Padres are sitting with a team WHIP of 1.306 and have a FIP of 3.74 as a unit on the year. They have a ranking of 16th in baseball as a pitching staff in total hits surrendered with 247. The San Diego pitching staff have conceded 131 runs on the season and come in with a team ERA of 4.23 (126 earned runs relinquished). Their strikeout to walk ratio comes in at 8.70 (260 strikeouts against 103 free passes). They have surrendered 25 home runs and they concede 4.40 runs per 9 innings (12th in MLB).

They are ranked 11th in the league with a save percentage of 66.7%, and they have sent 103 relief pitchers to the mound so far this year. Their relievers have come in 36 times in high leverage situations and on 29 occasions with runners on. Sitting with 43 save situations, the Padres have accrued 23 holds and 6 blown saves. San Diego has had bullpen pitchers enter the game in 18 save opportunities and they have walked away with 12 saves. San Diego relief pitchers hold an inherited score percentage of 38.0% of 50 inherited base runners.

The San Diego Padres have gotten 24 double plays and have a fielding percentage of .993 (2nd in baseball). The Padres have 270 assists, 8 errors and have accounted for 804 putouts so far this season. In 2,412 innings played, the Padres hold a efficiency on defense of 69.2% (22nd in professional baseball).

Marquez (71-73 career record) has a 4.67 ERA while giving up 9.2 hits per 9 innings. He has a strikeout to walk ratio of 3.01 and he has gone up against 5,012 hitters so far in his pro baseball career. He has conceded a total of 607 ER's while earning a WHIP of 1.335 and having a FIP of 4.6. During his career, Marquez has conceded 1,201 hits while he has totaled 1,086 punch outs in 1,170 innings pitched.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take San Diego (-196)

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