Chicago White Sox vs San Francisco Giants Prediction, 5/22/2026 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs San Francisco Giants

Date: Friday, May 22, 2026

Location: Oracle Park in San Francisco, CA

TV: NBC Bay Area

Odds/Point Spread: Chicago (+132) San Francisco (-160)

Oracle Park is the site where the San Francisco Giants (20-30) will meet the Chicago White Sox (25-24) on Friday. The odds on this game have the White Sox at +132 and the Giants are at -160. The over/under has been set at 8. The expected starting pitchers are Davis Martin and Trevor McDonald.

The White Sox have hit 58 two-baggers as a squad and have knocked 68 baseballs out of the park. Chicago is slugging .405 and have struck out 456 times, while drawing a walk on 186 occasions. As a unit, the Chicago White Sox are knocking in 4.5 runs per contest, which is 13th in baseball. They have amassed 207 runs batted in and 378 base knocks so far this season, and their team batting average sits at .235. They have a total of 218 runs scored while having a team on-base percentage of .323.

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Their strikeout to walk ratio is 1.97 and the pitching staff holds a WHIP of 1.36. White Sox pitchers have relinquished 53 home runs in addition to 230 total runs (21st in the league). Chicago has conceded 388 base knocks (8.0 per 9 innings) and 210 earned runs. The White Sox are sitting with a team earned run average of 4.35 on the season (24th in the league), and their staff has struck out 395 batters. They have walked 201 opposing players and their FIP comes in at 4.48 as a unit so far this year.

White Sox bullpen pitchers have entered the game with players on base 57 times in addition to having 49 appearances in high leverage situations. The relief pitchers have 16 holds for the season (27th in MLB). The White Sox bullpen have a save rate of 59.3% and have come into the game in 43 save situations. They have compiled 16 saves on the season and have blown 11 of their 27 save opportunities. The bullpen pitchers have inherited 86 base runners this season with 31.4% of those runners ended up crossing the plate. The White Sox have dispatched 171 relievers to the hill over the course of the season.

The White Sox have turned 70.9% of baseballs in play into outs out of their 3,912 innings on the field, which has them sitting at 11th in professional baseball. The Chicago White Sox have amassed 1,304 putouts so far this season, in addition to 432 assists and 24 errors. Their fielding rate is currently at .986 which has them ranked 16th in the majors, and they have turned 35 double plays.

Martin has taken the mound for 312 innings and has earned 258 punch outs during his pro baseball career. His ERA is 3.84 (133 earned runs allowed) and he has a WHIP of 1.263. He has conceded 294 base hits (8.5 hits per 9 innings) with 100 walks. Martin (16-22 career win-loss record) holds a FIP of 3.78 while he has faced 1,305 opposing batters in the majors.

San Francisco is sitting with 41 home runs on the season as well as 167 RBIs. They have notched 90 two-baggers, while getting a free base 105 times as well as putting up 173 runs. The San Francisco Giants have recorded an on-base percentage of .291 in addition to a batting average of .244 on the year. The Giants hold a team SLG% of .378 and they have an average of 3.46 runs per contest (30th in baseball). They have struck out on 391 instances (23rd in baseball) and have totaled 417 base hits.

The Giants have a team WHIP of 1.344 in addition to having a FIP of 4.21 as a team for the season. They have a ranking of 20th in MLB as a staff in total hits given up with 407. The San Francisco pitching staff have given up 225 runs on the year while having an ERA of 4.15 (204 earned runs allowed). They currently have a K/BB ratio of 7.90 (390 strikeouts against 187 free passes). They have allowed 51 home runs and they allow 4.58 runs per 9 innings (18th in the league).

San Francisco bullpen pitchers have an inherited score percentage of 29.9% out of their 77 inherited runners. Their relievers have come in 33 times in high leverage situations in addition to 52 occasions with runners on. Sitting with 43 save situations, the Giants have 28 holds and 6 blown saves. They rank 18th in the league with a save rate of 60.0%, and they have sent 161 bullpen pitchers to the mound this season.

In 3,978 innings played, the Giants hold a defensive efficiency of 69.7% (20th in professional baseball). The San Francisco Giants have gotten 55 double plays and own a fielding percentage of .984 (24th in baseball). The Giants have accrued 500 assists, 29 errors and have a tally of 1,326 putouts this season.

McDonald (3-0 career win-loss mark) has earned a 1.95 ERA and has given up 7.1 hits per 9 innings. He has a K/BB ratio of 5.33 and he has gone up against 146 batters in his MLB career. He has given up 8 ER's while earning a WHIP of 0.946 and being the owner of a FIP of 1.9. So far in his pro baseball career, McDonald has surrendered 29 base knocks and he has 32 strikeouts in 37 innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Chicago (+132)

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