Chicago White Sox vs Seattle Mariners Prediction, 5/20/2026 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs Seattle Mariners

Date: Wednesday, May 20, 2026

Location: T-Mobile Park in Seattle, WA

TV: MLB.TV

Odds/Point Spread: Chicago (+110) Seattle (-132)

The Seattle Mariners (22-25) will go up against the Chicago White Sox (23-22) at T-Mobile Park on Wednesday. The odds on this game have the White Sox at +110 and the Mariners are at -132. The betting total is set at 9. The expected starting pitchers are Sean Burke and Emerson Hancock.

Chicago is slugging .412 and have been called out on strikes 420 times, while drawing a walk on 176 occasions. They have recorded 201 RBI's as well as 357 hits so far this season, while their team batting average sits at .236. The White Sox have tallied 56 two-baggers as a team and have smacked 66 balls out of the stadium. They have tallied 211 runs scored and hold an OBP of .325. As a squad, the Chicago White Sox are notching 4.6 runs per game, which is 10th in MLB.

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They have a strikeout to walk ratio of 1.91 and the pitching staff sits with a WHIP of 1.38. White Sox pitchers have allowed 49 long balls and also 218 runs in total (23rd in the league). Chicago has allowed 372 base hits (8.2 per 9 innings) and 198 earned runs. The White Sox have compiled a team earned run average of 4.35 over the course of the season (22nd in the league), and their staff has struck out 366 hitters. Their pitching staff has walked 192 opposing hitters and their FIP comes in at 4.45 as a squad for the year.

The White Sox have dispatched 162 relief pitchers to the hill for the season. The relief pitchers have inherited 81 runners this year and 32.1% of those runners crossing the plate. The relief pitchers have earned 16 holds on the year (26th in the league). White Sox bullpen pitchers have come into the game with runners on 54 times and also have had 47 appearances in high leverage situations. They have accumulated 15 saves for the year and have not converted 11 of 26 save opportunities. The White Sox bullpen have earned a save percentage of 57.7% and have come into the game in 42 save situations.

The Chicago White Sox have earned 1,229 putouts at this point in the season, in addition to 417 assists and 23 errors. Their fielding percentage is currently at .986 which puts them in 18th in baseball, and they have turned 34 double plays. The White Sox have converted 70.6% of balls in play into outs out of 3,687 innings on the diamond, which has them ranked 11th in pro baseball.

Burke has taken the hill for 201 innings and has totaled 196 K's so far in his career. Burke (8-14 win-loss record in his career) has earned a FIP of 3.88 while he has gone up against 874 opposing batters during his time in the major leagues. His ERA is 3.94 (88 earned runs allowed) and he has a WHIP of 1.342. He has surrendered 189 base knocks (8.5 hits per 9 innings) and has 81 walks.

The Mariners have a team slugging % of .376 and they average 4.12 runs per game (22nd in the league). They have recorded 62 two-baggers, while walking 188 times and racking up 198 runs. Seattle has accumulated 54 home runs on the year as well as 193 runs batted in. They have been rung up on 433 occasions (4th in MLB) and have recorded 362 base knocks. The Seattle Mariners have recorded an on-base percentage of .319 in addition to a team batting average of .228 for the year.

The Seattle pitching staff have yielded 192 runs for the season while having a team ERA of 3.75 (178 earned runs allowed). They have given up 50 dingers and they relinquish 4.05 runs per 9 innings (7th in the league). The Mariners have a WHIP of 1.234 with a FIP of 3.76 as a staff so far this year. They currently have a K/BB ratio of 8.60 (407 strikeouts against 122 bases on balls). They come in at 24th in baseball as a staff in total hits allowed with 405.

They rank 17th in MLB holding a save percentage of 63.2%, and they have dispatched 149 relievers to the mound so far this season. Their relief pitchers have stepped onto the hill 59 times in high leverage situations and also on 37 occasions with base runners. With 43 save situations, the Mariners have earned 24 holds and 7 blown saves. Seattle has had relief pitchers take the mound in 19 save chances and they have tallied 12 saves. Seattle relief pitchers hold an inherited score percentage of 14.6% out of their 48 inherited runners.

In 3,846 innings on the field, the Mariners have earned a defensive efficiency of 69.0% (25th in pro baseball). The Seattle Mariners have turned 45 double plays and have a fielding percentage of .990 (3rd in the majors). The Mariners have 404 assists, 17 errors and have accounted for 1,282 putouts so far this season.

Hancock (11-11 mark in his career) has earned a 4.39 ERA and has given up 8.9 hits per nine innings. He has a K/BB ratio of 2.62 and he has faced 907 batters so far in his pro baseball career. He has surrendered a total of 105 ER's while holding a WHIP of 1.277 and a FIP of 4.3. In his pro baseball career, Hancock has allowed 212 base knocks while totaling 165 strikeouts in 215 innings pitched.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Seattle (-132)

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