Chicago White Sox vs St. Louis Cardinals Prediction, 9/11/2026 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs St. Louis Cardinals

Date: Friday, September 11, 2026

Location: Busch Stadium in St. Louis, MO

TV: Cardinals.TV

Odds/Point Spread: Chicago (-144) St. Louis (+120)

The St. Louis Cardinals (72-75) host the Chicago White Sox (75-70) at Busch Stadium on Friday. The odds on this game have the White Sox at -144 while the Cardinals are sitting at +120. The betting total comes in at 9. The expected starting pitchers will be Luis Castillo and Matthew Liberatore.

Chicago is slugging .407 and have been called out on strikes 1,327 times, while drawing a walk on 520 occasions. They have 654 RBI's as well as 1,150 base knocks this season, and their batting average comes in at .236. The White Sox have recorded 231 two-baggers as a squad and have hit 190 balls out of the park. They have tallied 685 runs while holding a team OBP of .319. As a team, the Chicago White Sox are recording 4.7 runs per outing, which has them sitting at 6th in the league.

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The White Sox hold a team ERA of 4.14 so far this year (14th in baseball), and they have struck out 1,200 hitters. White Sox pitchers have conceded 163 long balls in addition to 644 runs in total (12th in baseball). They have walked 520 players from the other team and their FIP is 4.28 as a team this season. Chicago has yielded 1,174 base hits (8.2 per 9 innings) as well as 595 earned runs. They have accrued a K/BB ratio of 2.31 and the pitching staff has a collective WHIP of 1.31.

The White Sox relievers have a save percentage of 58.7% and have entered the game in 121 save situations. They have compiled 37 saves on the year and have blown 26 out of their 63 save opportunities. The bullpen pitchers have inherited 232 base runners for the season with 30.2% of those runners earned a run for their team. White Sox relief pitchers have entered the contest with players on base 158 times in addition to having 142 appearances in high leverage situations. The White Sox have dispatched 482 relievers to the hill on the year. The relievers have racked up 55 holds on the season (29th in baseball).

The Chicago White Sox are sitting with 3,876 putouts this season, as well as 1,179 assists and 73 errors. Their fielding percentage is holding steady at .986 which has them ranked 16th in MLB, and have accumulated 99 double plays. The White Sox have transformed 70.4% of baseballs in play into outs in their 11,628 innings, which has them ranked 12th in MLB.

Castillo has taken the mound for 1,436 frames and has tallied 1,516 strikeouts during his pro baseball career. Castillo (85-86 career record) is the owner of a FIP of 3.57 and he has gone up against 5,948 hitters in the major leagues. His ERA is 3.63 (579 ER's allowed) and he has a WHIP of 1.188. He has conceded 1,245 hits (7.8 hits per 9 innings) and has 461 walks.

St. Louis has tallied 156 home runs this year to go along with 648 runs batted in. They have 209 two-baggers, while taking a walk 470 times as well as recording 668 runs. The St. Louis Cardinals hold an on-base percentage of .317 and a team batting average of .243 on the campaign. The Cardinals hold a team SLG% of .385 and they are scoring 4.54 runs per contest (11th in the league). They have struck out on 1,156 occasions (25th in baseball) and are sitting with 1,208 base hits.

The Cardinals have a WHIP of 1.352 in addition to having a FIP of 4.08 as a squad this season. They have a ranking of 25th in MLB as a staff in total hits surrendered with 1,269. The St. Louis pitching staff have relinquished 680 runs on the campaign while having an ERA of 4.31 (627 earned runs surrendered). They have earned a K/BB ratio of 8.00 (1,160 strikeouts vs 501 free passes). They have surrendered 146 home runs and they relinquish 4.67 runs per 9 innings (21st in MLB).

They rank 18th in baseball holding a save percentage of 60.6%, and they have dispatched 499 relievers to the mound on the year. Their relief pitchers have stepped onto the mound 182 times in high leverage situations in addition to 151 occasions with runners on. With 168 save situations, the Cardinals have compiled 93 holds in addition to 28 blown saves. St. Louis has called on bullpen pitchers to enter the game in 71 save chances and they have tallied 43 saves. St. Louis bullpen pitchers have an inherited score rate of 41.0% out of their 222 inherited runners.

In their 11,787 innings played, the Cardinals are sitting with a defensive efficiency of 69.0% (25th in the majors). The St. Louis Cardinals have gotten 141 double plays and have a fielding percentage of .988 (5th in the majors). The Cardinals have recorded 1,363 assists, 63 errors and have amassed 3,929 putouts so far this year.

Liberatore (21-38 career win-loss mark) is the owner of a 4.91 ERA and has conceded 9.6 hits per nine innings. He has a K/BB ratio of 2.60 and he has faced 2,050 opposing hitters in his pro baseball career. He has allowed 258 earned runs while earning a WHIP of 1.400 and a FIP of 4.8. So far in his pro baseball career, Liberatore has surrendered 502 base knocks and he has 416 punch outs in 473 innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take St. Louis (+120)

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