Chicago White Sox vs St. Louis Cardinals Prediction, 9/12/2026 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs St. Louis Cardinals

Date: Saturday, September 12, 2026

Location: Busch Stadium in St. Louis, MO

TV: Cardinals.TV

Odds/Point Spread: Chicago (-132) St. Louis (+110)

Busch Stadium is the location where the St. Louis Cardinals (72-75) will meet the Chicago White Sox (75-71) on Saturday. The line on this contest has the White Sox at -132 and the Cardinals are sitting at +110. The total comes in at 9. The pitchers who are expected to start are Luis Castillo and Cooper Hjerpe.

The White Sox have compiled 232 two-baggers as a unit and have hit 190 balls out of the park. Chicago has a slugging % of .405 and have struck out 1,338 times, while drawing a walk on 522 occasions. As a squad, the Chicago White Sox are recording 4.7 runs per outing, which is 7th in the league. They have earned 654 runs batted in as well as 1,152 base knocks this year, and their average at the plate is .235. They have 685 runs and hold an OBP of .317.

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They have a strikeout to walk ratio of 2.31 and their pitching staff has earned a collective WHIP of 1.31. White Sox pitchers have conceded 164 long balls and also 646 runs in total (12th in MLB). Chicago has yielded 1,181 base knocks (8.2 per 9 innings) and 597 earned runs. The White Sox have compiled a team earned run average of 4.13 on the season (14th in baseball), and they have rung up 1,206 hitters. They have walked 521 players from the other team and their FIP is 4.27 as a unit over the course of the season.

The White Sox relievers have compiled a save rate of 58.7% and have come into the game in 121 save situations. They have compiled 37 saves so far this season and have blown 26 of 63 chances to get a save. The relievers have inherited 234 runners this season with 30.3% of those runners ended up scoring. White Sox pitchers have entered the contest with runners on 160 times as well as having 143 appearances in high leverage situations. The White Sox have dispatched 485 relief pitchers to the mound on the year. The bullpen have recorded 55 holds on the year (29th in the league).

The White Sox have converted 70.5% of balls in play into outs out of 11,709 innings, which ranks them 12th in pro baseball. The Chicago White Sox have accumulated 3,903 putouts on the year, in addition to 1,187 assists and 73 errors. Their fielding percentage is currently at .986 which puts them in 14th in baseball, and have 101 double plays.

Castillo (85-86 mark in his career) holds a FIP of 3.57 and he has gone up against 5,948 opposing batters during his time in the major leagues. He has conceded 1,245 base hits (7.8 hits per nine innings) and has 461 free passes. His ERA is 3.63 (579 ER's allowed) and his career WHIP is 1.188. Castillo has pitched in 1,436 frames and has accumulated 1,516 K's during his pro baseball career.

The St. Louis Cardinals have accounted for a team OBP of .317 in addition to a batting average of .243 this season. They have been rung up on 1,156 occasions (25th in MLB) and have earned a total of 1,207 base knocks. St. Louis has knocked in 156 home runs so far this season and 648 RBIs. The Cardinals have a team slugging % of .385 and they are earning 4.54 runs per game (11th in the league). They have put up 209 two-baggers, while walking 470 times as well as racking up 668 runs.

The Cardinals are sitting with a team WHIP of 1.352 and have a FIP of 4.08 as a squad on the campaign. Their K/BB ratio is 8.00 (1,160 strikeouts vs 501 bases on balls). They rank 25th in baseball as a pitching staff in total hits surrendered with 1,269. They have relinquished 146 long balls and they relinquish 4.67 runs per 9 innings (21st in the league). The St. Louis pitching staff have allowed 680 runs over the course of the season and come in with a team ERA of 4.31 (627 earned runs given up).

With 168 save situations, the Cardinals have accrued 93 holds in addition to 28 blown saves. St. Louis has called on bullpen pitchers to step onto the hill in 71 save opportunities and they have earned 43 saves. St. Louis relievers hold an inherited score percentage of 41.0% out of their 222 inherited runners. Their bullpen pitchers have stepped onto the mound 182 times in high leverage situations and on 151 occasions with base runners. They are ranked 18th in baseball with a save rate of 60.6%, and they have dispatched 499 bullpen pitchers onto the field on the year.

The St. Louis Cardinals have gotten 141 double plays and hold a fielding percentage of .988 (5th in professional baseball). The Cardinals have recorded 1,363 assists, 63 errors and have a tally of 3,929 putouts for the year. In 11,787 innings played, the Cardinals have a defensive efficiency of 69.0% (25th in professional baseball).

So far in his MLB career, Hjerpe has allowed 0 base knocks while tallying 6 K's in 4 innings pitched. He has allowed a total of 0 ER's while holding a WHIP of 0.000 and a FIP of 0.0. He has a K/BB ratio of 0.00 and he has gone up against 12 opposing hitters so far in his MLB career. Hjerpe (1-0 career mark) has earned a 0.00 ERA while conceding 0.0 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Chicago (-132)

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