Chicago White Sox vs St. Louis Cardinals Prediction, 9/13/2026 MLB Picks, Best Bets & Odds

Game: Chicago White Sox vs St. Louis Cardinals

Date: Sunday, September 13, 2026

Location: Busch Stadium in St. Louis, MO

TV: Cardinals.TV

Odds/Point Spread: Chicago (-128) St. Louis (+106)

The St. Louis Cardinals (72-75) will try to defeat the Chicago White Sox (75-71) at Busch Stadium on Sunday. The line on this contest has Chicago at -128 while St. Louis opens at +106. The over/under comes in at 9. The pitchers who are expected to start are Sean Burke and Michael McGreevy.

As a team, the Chicago White Sox are putting up 4.7 runs per game, which is 7th in the league. They have tallied 685 runs while having a team OBP of .317. The White Sox have accumulated 232 two-baggers as a squad and have hit 190 balls out of the park. They have 654 runs batted in in addition to 1,152 base knocks for the season, while their batting average is sitting at .235. Chicago is slugging .405 and have been called out on strikes 1,338 times, while being walked on 522 occasions.

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The White Sox have a team ERA of 4.13 over the course of the season (14th in MLB), and they have rung up 1,206 hitters. White Sox pitchers have yielded 164 home runs in addition to 646 runs (12th in the league). They have walked 521 opposing batters and their FIP is 4.27 as a squad on the year. Chicago has yielded 1,181 hits (8.2 per 9 innings) as well as 597 earned runs. Their strikeout to walk ratio is 2.31 and the pitching staff has earned a collective WHIP of 1.31.

White Sox pitchers have stepped onto the hill with opponents on base 160 times in addition to having 143 appearances in high leverage situations. The relief pitchers have notched 55 holds on the season (29th in the league). The White Sox relief pitchers have recorded a save percentage of 58.7% and have stepped onto the mound in 121 save situations. They have earned 37 saves this year and have blown 26 of their 63 save chances. The relief pitchers have inherited 234 base runners on the season and 30.3% of them ended up crossing the plate. The White Sox have sent 485 relievers to the hill for the season.

The White Sox have turned 70.5% of balls hit into play into outs out of their 11,709 innings, which ranks them 12th in pro baseball. The Chicago White Sox have earned a total of 3,903 putouts over the course of the season, as well as 1,187 assists and 73 errors. Their fielding rate is holding steady at .986 which has them ranked 14th in baseball, and they have turned 101 double plays.

Burke (14-18 career win-loss mark) sits with a FIP of 3.67 while he has faced 1,321 hitters in the major leagues. He has allowed 274 base hits (8.0 hits per nine innings) with 126 free passes. His ERA is 3.73 (128 earned runs allowed) and he has a WHIP of 1.294. Burke has pitched in 309 innings and has totaled 324 K's in his MLB career.

The Cardinals have a team slugging % of .385 and they score 4.54 runs per contest (11th in MLB). They have 209 two-baggers, while taking a walk 470 times as well as earning 668 runs. St. Louis has 156 HRs this year to go along with 648 runs batted in. They have struck out on 1,156 occasions (25th in baseball) and have tallied 1,207 base hits. The St. Louis Cardinals have tallied a team on-base percentage of .317 in addition to a batting average of .243 for the year.

The Cardinals have a WHIP of 1.352 in addition to having a FIP of 4.08 as a unit on the season. They have earned a strikeout to walk ratio of 8.00 (1,160 strikeouts against 501 bases on balls). They come in at 25th in the league as a staff in total hits relinquished with 1,269. They have surrendered 146 home runs and they relinquish 4.67 runs per 9 innings (21st in the league). The St. Louis pitching staff have given up 680 runs over the course of the season and come in with a team ERA of 4.31 (627 earned runs conceded).

They are ranked 18th in the league with a save percentage of 60.6%, and they have sent 499 relief pitchers to the hill over the course of the season. Their bullpen pitchers have taken the field 182 times in high leverage situations in addition to 151 occasions with runners on base. With 168 save situations, the Cardinals have amassed 93 holds and 28 blown saves. St. Louis has called on bullpen pitchers to step onto the hill in 71 save chances and they have earned 43 saves. St. Louis relief pitchers have an inherited score percentage of 41.0% out of their 222 inherited runners.

Out of their 11,787 innings played, the Cardinals hold a efficiency on defense of 69.0% (25th in MLB). The St. Louis Cardinals have turned 141 double plays and own a fielding percentage of .988 (5th in baseball). The Cardinals have accrued 1,363 assists, 63 errors and have amassed 3,929 putouts this year.

In his pro baseball career, McGreevy has allowed 267 base knocks while he has accumulated 182 strikeouts in 272 innings pitched. McGreevy (17-13 career mark) has a 3.93 earned run average and has conceded 8.8 hits per 9 innings. He has surrendered 119 ER's while earning a WHIP of 1.216 and being the owner of a FIP of 3.9. His strikeout to walk ratio is 2.84 and he has faced 1,121 batters thus far in his career.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Chicago (-128)

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