Cincinnati Reds vs Arizona Diamondbacks Prediction, 8/21/2026 MLB Picks, Best Bets & Odds

Game: Cincinnati Reds vs Arizona Diamondbacks

Date: Friday, August 21, 2026

Location: Chase Field in Phoenix, AZ

TV: DBACKS.TV

Odds/Point Spread: Cincinnati (+106) Arizona (-128)

Chase Field is the location where the Arizona Diamondbacks (67-61) will play the Cincinnati Reds (61-66) on Friday. The line on this contest has Cincinnati at +106 and Arizona is priced at -128. The total is 8.5. The pitchers who are expected to start are Nick Lodolo and Eduardo Rodriguez.

As a squad, the Cincinnati Reds are notching 4.1 runs per contest, which ranks them 25th in MLB. They have accumulated 514 runs while holding a team OBP of .305. The Reds have accrued 182 doubles as a unit and have hit 164 balls out of the park. They have amassed 490 runs batted in as well as 951 base knocks so far this season, and their average at the plate sits at .226. Cincinnati has a slugging rate of .391 and have been rung up 1,211 times, while taking a walk on 450 occasions.

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The Reds have an ERA of 4.48 so far this year (24th in baseball), and their staff has rung up 1,033 batters. Reds pitchers have surrendered 158 long balls and also 602 total runs (22nd in the league). They have walked 525 players from the other team and their FIP comes in at 4.63 as a squad over the course of the season. Cincinnati has given up 1,060 hits (8.4 per 9 innings) as well as 562 earned runs. Their strikeout to walk ratio sits at 1.97 and their pitching staff has earned a collective WHIP of 1.40.

The Reds bullpen have earned a save rate of 63.5% and have stepped onto the mound in 126 save situations. They have recorded 33 saves so far this year and have blown 19 of 52 save chances. The relievers have inherited 194 runners on the campaign with 27.8% of those players crossing home plate. Reds relief pitchers have entered the game with players on base 136 times as well as having 159 appearances in high leverage situations. The Reds have sent 447 relief pitchers to the hill so far this season. The bullpen have earned 71 holds on the season (11th in MLB).

The Reds have transformed 70.2% of balls in play into outs in their 10,170 innings, which has them sitting 14th in baseball. The Cincinnati Reds have 3,390 putouts for the season, in addition to 1,022 assists and 69 errors. Their fielding percentage is holding at .985 which has them ranked 20th in the majors, and have a total of 87 double plays.

Lodolo has thrown 480 innings and has accounted for 513 strikeouts during his MLB career. Lodolo (27-24 career record) has earned a FIP of 4.08 and he has faced 2,058 hitters in the majors. His ERA is 4.14 (221 earned runs allowed) and his career WHIP is 1.245. He has surrendered 452 base knocks (8.5 hits per nine innings) with 146 walks.

The Arizona Diamondbacks have an on-base percentage of .316 and a team batting average of .243 for the year. They have been rung up on 936 occasions (28th in the league) and have accounted for 1,044 hits. Arizona has compiled 126 home runs on the year and 551 RBIs. The Diamondbacks have a team SLG% of .398 and they are earning 4.52 runs per outing (14th in the league). They have recorded 220 doubles, while getting a free base 431 times and scoring 579 runs.

The Diamondbacks have a WHIP of 1.289 in addition to having a FIP of 4.38 as a pitching staff over the course of the season. They are currently ranked 23rd in baseball as a pitching staff in total hits given up with 1,091. The Arizona pitching staff have relinquished 575 runs this season while having a team ERA of 4.18 (527 earned runs given up). They currently have a K/BB ratio of 6.90 (865 strikeouts vs 373 bases on balls). They have allowed 149 HR's and they give up 4.56 runs per 9 innings (19th in the league).

With 118 save situations, the Diamondbacks have earned 71 holds and also 15 blown saves. Arizona has had bullpen pitchers enter the game in 46 save opportunities and they have tallied 31 saves. Arizona relievers have an inherited score rate of 24.8% of 165 inherited runners. Their bullpen pitchers have stepped onto the mound 137 times in high leverage situations and also on 111 occasions with runners on base. They are ranked 12th in the league holding a save percentage of 67.4%, and they have dispatched 421 bullpen pitchers to the hill over the course of the season.

The Arizona Diamondbacks have gotten 114 double plays and have a fielding rate of .989 (2nd in baseball). The Diamondbacks have recorded 1,114 assists, 48 errors and have 3,408 putouts for the year. In 10,224 innings played, the Diamondbacks have a defensive efficiency of 71.1% (8th in the majors).

During his MLB career, Rodriguez has allowed 1,414 hits while earning 1,403 strikeouts in 1,453 frames. Rodriguez (106-70 mark in his career) has a 4.04 ERA and has allowed 8.8 hits per 9 innings. He has allowed 652 earned runs while holding a WHIP of 1.318 and being the owner of a FIP of 4.0. His strikeout to walk ratio is 2.79 and he has gone up against 6,192 batters thus far in his career.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Arizona (-128)

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