Cincinnati Reds vs Arizona Diamondbacks Prediction, 8/22/2026 MLB Picks, Best Bets & Odds

Game: Cincinnati Reds vs Arizona Diamondbacks

Date: Saturday, August 22, 2026

Location: Chase Field in Phoenix, AZ

TV: DBACKS.TV

Odds/Point Spread: Cincinnati (+125) Arizona (-150)

The Cincinnati Reds (61-67) are hitting the road to Chase Field on Saturday where they will take on the Arizona Diamondbacks (67-61). The line on this contest has the Reds at +125 while the Diamondbacks are sitting at -150. The total is 8.5. The starting pitchers will be Rhett Lowder and Michael Soroka.

As a squad, the Cincinnati Reds are notching 4.1 runs per outing, which has them sitting at 25th in MLB. They have accounted for 523 runs scored while holding a team OBP of .305. The Reds have hit 182 doubles as a unit and have hit 165 baseballs out of the park. They have tallied 499 RBI's as well as 958 base knocks this season, while their average at the plate is at .226. Cincinnati is slugging .390 and have been rung up 1,220 times, while being walked on 458 occasions.

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The Reds hold a team ERA of 4.47 for the year (24th in the league), and the staff has struck out 1,039 hitters. Reds pitchers have allowed 159 long balls and 612 runs (23rd in MLB). They have walked 531 batters and their FIP is 4.65 as a team on the year. Cincinnati has conceded 1,068 base hits (8.4 per 9 innings) as well as 566 earned runs. They have a strikeout to walk ratio of 1.96 and the pitching staff holds a WHIP of 1.40.

The Reds relievers have recorded a save rate of 62.3% and have entered the game in 129 save situations. They have 33 saves on the season and have blown 20 of their 53 save opportunities. The bullpen pitchers have inherited 197 runners for the season with 28.4% of those players earned a run for their team. Reds pitchers have entered the contest with runners on 137 times in addition to having 162 appearances in high leverage situations. The Reds have dispatched 451 relievers to the hill on the year. The relievers have 73 holds on the year (10th in baseball).

The Cincinnati Reds have 3,417 putouts this year, in addition to 1,032 assists and 71 errors. Their fielding rate is at .984 which ranks 20th in professional baseball, and they have turned 89 double plays. The Reds have converted 70.2% of balls hit into play into outs out of 10,251 innings on the diamond, which has them sitting 13th in the majors.

Lowder has thrown 131 innings and has earned 104 punch outs during his MLB career. Lowder (6-10 career mark) has earned a FIP of 4.19 and he has faced 580 hitters in the major leagues. His ERA is 4.25 (62 earned runs allowed) and he has a career WHIP of 1.441. He has conceded 133 base knocks (9.1 hits per nine innings) with 56 free passes.

The Arizona Diamondbacks have tallied an OBP of .316 and a team batting average of .243 so far this year. They have struck out on 936 instances (29th in MLB) and have accounted for 1,044 hits. Arizona is sitting with 126 home runs on the season as well as 551 RBIs. The Diamondbacks hold a team slugging percentage of .398 and they are earning 4.52 runs per game (14th in baseball). They have hit 220 two-baggers, while taking a walk 431 times and notching 579 runs.

The Diamondbacks hold a team WHIP of 1.289 and are the owners of a FIP of 4.38 as a pitching staff over the course of the season. Their strikeout to walk ratio sits at 6.90 (865 strikeouts vs 373 free passes). They are sitting at 23rd in baseball as a pitching staff in total hits relinquished with 1,091. They have yielded 149 dingers and they yield 4.56 runs per 9 innings (19th in baseball). The Arizona pitching staff have relinquished 575 runs this year while holding a team ERA of 4.18 (527 earned runs relinquished).

With 118 save situations, the Diamondbacks have amassed 71 holds and 15 blown saves. Arizona has called on relievers to take the mound in 46 save chances and they have come away with 31 saves. Arizona bullpen pitchers hold an inherited score percentage of 24.8% out of their 165 inherited base runners. Their relief pitchers have taken the field 137 times in high leverage situations and on 111 occasions with runners on base. They are ranked 12th in baseball holding a save percentage of 67.4%, and they have dispatched 421 relief pitchers onto the field so far this year.

In their 10,224 innings on the diamond, the Diamondbacks have earned a defensive efficiency of 71.1% (8th in MLB). The Arizona Diamondbacks have turned 114 double plays and hold a fielding percentage of .989 (2nd in pro baseball). The Diamondbacks have 1,114 assists, 48 errors and have earned a total of 3,408 putouts on the campaign.

Soroka (28-29 career mark) has a 3.69 ERA while giving up 8.0 hits per nine innings. He has a K/BB ratio of 2.90 and he has gone up against 2,117 batters in his MLB career. He has surrendered a total of 208 earned runs while holding a WHIP of 1.203 and a FIP of 3.6. So far in his career, Soroka has conceded 449 hits while totaling 467 strikeouts in 507 frames.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Cincinnati (+125)

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