Cincinnati Reds vs Chicago Cubs Prediction, 5/6/2026 MLB Picks, Best Bets & Odds

Game: Cincinnati Reds vs Chicago Cubs

Date: Wednesday, May 6, 2026

Location: Wrigley Field in Chicago, IL

TV: Marquee

Odds/Point Spread: Cincinnati (+102) Chicago (-122)

The Chicago Cubs (23-12) are welcoming the Cincinnati Reds (20-15) at Wrigley Field on Wednesday. The moneyline on this contest has the Reds at +102 while the Cubs are priced at -122. The total comes in at 8.5. The starting pitchers are Brady Singer and Colin Rea.

As a unit, the Cincinnati Reds are knocking in 4.1 runs per game, which is 22nd in the league. They are sitting with 145 runs scored and have an OBP of .306. The Reds have recorded 50 doubles as a team and have hit 46 balls out of the stadium. They have 134 RBI's and 254 base knocks so far this season, and their average at the plate is .220. Cincinnati has a slugging percentage of .385 and have been called out on strikes 327 times, while being walked on 137 occasions.

Get all of our MLB Betting Picks

They have a strikeout to walk ratio of 1.64 and the pitching staff holds a WHIP of 1.50. Reds pitchers have conceded 38 home runs in addition to 168 total runs (21st in MLB). Cincinnati has surrendered 303 hits (8.7 per 9 innings) as well as 157 earned runs. The Reds have a team ERA of 4.52 so far this year (22nd in MLB), and the staff has struck out 273 hitters. They have walked 166 hitters and their FIP is 4.71 as a team on the season.

The Reds relief pitchers have recorded a save rate of 62.5% and have entered the game in 42 save situations. They have recorded 10 saves so far this season and have missed out on 6 of their 16 save opportunities. The relievers have inherited 55 runners on the campaign and 23.6% of them earned a run for their team. Reds pitchers have entered the game with runners on 38 times in addition to having 43 appearances in high leverage situations. The Reds have dispatched 130 relief pitchers to the mound this season. The bullpen have a total of 25 holds on the year (4th in the league).

The Cincinnati Reds have amassed 938 putouts at this point in the season, as well as 302 assists and 14 errors. Their fielding percentage is holding at .989 which has them sitting 6th in MLB, and have accumulated 35 double plays. The Reds have turned 69.4% of balls hit into play into outs out of 2,814 innings on the field, which has them sitting 18th in pro baseball.

Singer has taken the ball for 887 innings and is sitting with 828 strikeouts thus far in his career. Singer (52-58 win-loss record in his career) sits with a FIP of 4.22 while facing 3,803 opposing batters during his time in the majors. His ERA is 4.28 (422 ER's allowed) and his WHIP is 1.325. He has conceded 892 base knocks (9.0 hits per nine innings) and has had 283 free passes.

The Cubs have a slugging percentage of .431 and they tally 5.43 runs per game (3rd in MLB). They have hit 56 doubles, while getting a free base 161 times as well as racking up 190 runs. Chicago has recorded 46 HRs on the campaign and 174 runs batted in. They have been called out on strikes on 282 occasions (20th in the league) and have 310 hits. The Chicago Cubs are sitting with a team OBP of .352 in addition to a team batting average of .259 for the season.

The Cubs hold a team WHIP of 1.186 and are the owners of a FIP of 4.10 as a team so far this year. They have earned a strikeout to walk ratio of 8.40 (290 strikeouts vs 104 bases on balls). They are sitting at 9th in baseball as a staff in total hits given up with 266. They have allowed 41 homers and they allow 4.24 runs per 9 innings (11th in MLB). The Chicago pitching staff have given up 147 runs over the course of the season while having an ERA of 3.89 (135 earned runs surrendered).

Chicago relievers hold an inherited score rate of 32.6% of 46 inherited base runners. Their relief pitchers have come in 34 times in high leverage situations and on 34 occasions with runners on base. With 21 save situations, the Cubs have recorded 7 holds and 5 blown saves. They are currently ranked 18th in baseball holding a save rate of 61.5%, and they have sent 102 bullpen pitchers to the mound for the season.

Out of their 2,808 innings played, the Cubs have accumulated a defensive efficiency of 72.1% (4th in professional baseball). The Chicago Cubs have turned 23 double plays and have a fielding rate of .987 (12th in the majors). The Cubs have 314 assists, 17 errors and have 936 putouts for the year.

So far in his pro baseball career, Rea has given up 621 base knocks while he has accumulated 523 punch outs in 638 innings pitched. Rea (41-28 career record) has earned a 4.41 ERA and has allowed 8.8 hits per nine innings. He has given up a total of 313 earned runs while holding a WHIP of 1.272 and being the owner of a FIP of 4.3. He has a strikeout to walk ratio of 2.74 and he has gone up against 2,708 hitters thus far in his career.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Cincinnati (+102)

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get MLB picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.