Cincinnati Reds vs Chicago White Sox Prediction, 8/12/2026 MLB Picks, Best Bets & Odds

Game: Cincinnati Reds vs Chicago White Sox

Date: Wednesday, August 12, 2026

Location: Rate Field in Chicago, IL

TV: Chicago Sports Network

Odds/Point Spread: Cincinnati (-160) Chicago (+132)

Rate Field is the site where the Chicago White Sox (61-56) will go up against the Cincinnati Reds (56-61) on Wednesday. The moneyline on this game has the Reds at -160 while the White Sox are at +132. The total is set at 9. The pitchers expected to start will be Rhett Lowder and Luis Castillo.

Cincinnati has a slugging percentage of .397 and have been rung up 1,113 times, while drawing a walk on 424 occasions. They have compiled 459 runs batted in in addition to 890 base knocks for the year, and their batting average is at .229. The Reds have accumulated 172 doubles as a team and have hit 154 balls out of the stadium. They have racked up 482 runs scored and have an on-base percentage of .309. As a squad, the Cincinnati Reds are compiling 4.1 runs per outing, which has them at 25th in the league.

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The Reds have an earned run average of 4.48 this season (23rd in baseball), and they have struck out 936 hitters. Reds pitchers have relinquished 146 long balls and 556 total runs (21st in the league). Their pitching staff has walked 490 hitters and their FIP comes in at 4.69 as a unit this year. Cincinnati has conceded 971 hits (8.4 per 9 innings) in addition to 517 earned runs. They have a K/BB ratio of 1.91 and their pitching staff holds a collective WHIP of 1.41.

The Reds bullpen have earned a save rate of 61.7% and have stepped onto the mound in 116 save situations. They have earned 29 saves this year and have blown 18 of their 47 save opportunities. The bullpen pitchers have inherited 181 runners on the campaign with 27.6% of those players crossing the plate. Reds relief pitchers have entered the game with opponents on base 127 times in addition to having 143 appearances in high leverage situations. The Reds have dispatched 412 relievers to the mound this year. The relief pitchers have earned 66 holds this season (11th in the league).

The Cincinnati Reds have accounted for 3,117 putouts at this point in the season, in addition to 950 assists and 63 errors. Their fielding percentage is holding at .985 which is 18th in MLB, and they have turned 81 double plays. The Reds have transformed 70.5% of balls in play into outs out of their 9,351 innings on the field, ranking them 11th in pro baseball.

Lowder has taken the ball for 119 innings and has racked up 95 punch outs during his career. Lowder (6-9 career win-loss mark) is the owner of a FIP of 4.16 while he has faced 528 opposing batters during his time in the major leagues. His ERA is 4.23 (56 ER's allowed) and he has a WHIP of 1.435. He has surrendered 118 base hits (8.9 hits per nine innings) and has 53 free passes.

Chicago has hit 152 home runs over the course of the season to go along with 531 runs batted in. They have recorded 180 two-baggers, while taking a walk 401 times and racking up 557 runs. The Chicago White Sox are sitting with a team on-base percentage of .317 in addition to a batting average of .237 on the season. The White Sox have a team slugging percentage of .405 and they score 4.76 runs per game (8th in MLB). They have been called out on strikes on 1,067 occasions (6th in MLB) and have a total of 930 hits.

The White Sox have a team WHIP of 1.308 in addition to having a FIP of 4.20 as a team over the course of the season. They rank 9th in baseball as a pitching staff in total hits given up with 937. The Chicago pitching staff have relinquished 520 runs this year while having an ERA of 4.11 (476 earned runs surrendered). Their strikeout to walk ratio comes in at 8.50 (988 strikeouts against 427 walks). They have allowed 127 homers and they allow 4.49 runs per 9 innings (14th in MLB).

Sitting with 100 save situations, the White Sox have 48 holds and also 22 blown saves. Chicago has called on relievers to enter the game in 52 save opportunities and they have walked away with 30 saves. Chicago bullpen pitchers hold an inherited score percentage of 31.9% out of their 185 inherited base runners. Their relief pitchers have stepped onto the mound 118 times in high leverage situations and on 128 occasions with runners on base. They sit at 23rd in MLB holding a save percentage of 57.7%, and they have dispatched 397 relief pitchers to the hill for the year.

The Chicago White Sox have turned 83 double plays and have accounted for a fielding rate of .984 (20th in professional baseball). The White Sox have 959 assists, 65 errors and have accumulated 3,130 putouts for the year. In 9,390 innings on the diamond, the White Sox are sitting with a efficiency on defense of 70.2% (12th in professional baseball).

Castillo (84-84 career mark) holds a 3.58 earned run average while allowing 7.7 hits per nine innings. He has a K/BB ratio of 3.30 and he has gone up against 5,842 opposing batters thus far in his career. He has given up a total of 562 ER's while holding a WHIP of 1.179 and a FIP of 3.5. During his MLB career, Castillo has surrendered 1,214 base hits while totaling 1,498 strikeouts in 1,414 innings.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Cincinnati (-160)

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