Cincinnati Reds vs San Francisco Giants Prediction, 8/26/2026 MLB Picks, Best Bets & Odds

Game: Cincinnati Reds vs San Francisco Giants

Date: Wednesday, August 26, 2026

Location: Oracle Park in San Francisco, CA

TV: NBC Bay Area

Odds/Point Spread: Cincinnati (+110) San Francisco (-130)

The Cincinnati Reds (62-70) are headed to Oracle Park on Wednesday where they will compete against the San Francisco Giants (53-78). The moneyline on this matchup has the Reds at +110 and the Giants are priced at -130. The betting total comes in at 8. The pitchers taking the mound are Nick Lodolo and Landen Roupp.

As a squad, the Cincinnati Reds are notching 4.1 runs per game, which puts them at 25th in MLB. They have earned 537 runs while holding a team OBP of .306. The Reds have accrued 188 two-baggers as a unit and have hit 169 balls out of the stadium. They have accounted for 513 RBI's in addition to 991 hits this year, while their batting average is sitting at .226. Cincinnati is slugging .390 and have struck out 1,258 times, while drawing a walk on 473 occasions.

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Their K/BB ratio is 1.95 and the pitching staff has a team WHIP of 1.41. Reds pitchers have relinquished 163 home runs and also 636 total runs (24th in baseball). Cincinnati has surrendered 1,111 hits (8.5 per 9 innings) and 589 earned runs. The Reds hold a team ERA of 4.52 this year (24th in baseball), and the staff has rung up 1,061 batters. Their pitching staff has walked 544 opposing players and their FIP comes in at 4.64 as a unit this year.

Reds relief pitchers have come into the game with players on base 140 times and also have had 163 appearances in high leverage situations. The relief pitchers have notched 73 holds for the season (12th in MLB). The Reds bullpen have recorded a save rate of 61.1% and have come into the game in 130 save situations. They have recorded 33 saves over the course of the season and have blown 21 out of their 54 save chances. The bullpen pitchers have inherited 202 runners so far this year with 29.2% of them ended up scoring. The Reds have sent 462 relief pitchers to the hill on the season.

The Cincinnati Reds have amassed 3,516 putouts at this point in the season, in addition to 1,064 assists and 72 errors. Their fielding percentage is holding steady at .985 which puts them in 20th in the majors, and have earned 91 double plays. The Reds have turned 70.0% of balls in play into outs in their 10,548 innings, which ranks them 14th in the majors.

Lodolo has taken the ball for 484 frames and has accumulated 515 K's during his career. His ERA is 4.22 (227 ER's allowed) and his WHIP is 1.260. He has surrendered 462 base hits (8.6 hits per nine innings) with 148 walks. Lodolo (27-25 career mark) holds a FIP of 4.16 while going up against 2,080 hitters in the major leagues.

The Giants have a SLG% of .405 and they earn 4.03 runs per outing (26th in the league). They have 217 doubles, while getting a free base 345 times and scoring 528 runs. San Francisco has accounted for 145 home runs on the year as well as 507 runs batted in. They have been rung up on 1,043 instances (24th in the league) and have accounted for 1,100 base knocks. The San Francisco Giants have accumulated a team OBP of .305 as well as a batting average of .247 over the course of the season.

The Giants hold a team WHIP of 1.358 with a FIP of 4.14 as a team this year. They are sitting at 17th in MLB as a pitching staff in total hits given up with 1,077. The San Francisco pitching staff have conceded 603 runs on the year while having a team ERA of 4.32 (554 earned runs given up). Their strikeout to walk ratio comes in at 7.70 (987 strikeouts against 489 walks). They have given up 119 homers and they yield 4.71 runs per 9 innings (20th in MLB).

With 106 save situations, the Giants have tallied 62 holds and also 20 blown saves. San Francisco has called on relief pitchers to enter the contest in 44 save opportunities and they have earned 24 saves. San Francisco relief pitchers have an inherited score percentage of 35.2% out of their 227 inherited runners. Their relief pitchers have taken the field 108 times in high leverage situations in addition to 149 occasions with runners on. They rank 27th in the league holding a save percentage of 54.5%, and they have sent 412 relievers to the mound on the campaign.

In 10,380 innings on the field, the Giants are sitting with a defensive efficiency of 69.5% (21st in baseball). The San Francisco Giants have turned 119 double plays and own a fielding percentage of .982 (26th in pro baseball). The Giants have racked up 1,227 assists, 84 errors and have earned 3,460 putouts so far this season.

So far in his MLB career, Roupp has given up 269 base hits while earning 279 punch outs in 291 innings pitched. He has allowed a total of 130 earned runs while earning a WHIP of 1.387 and having a FIP of 4.0. He has a K/BB ratio of 2.07 and he has gone up against 1,267 hitters thus far in his career. Roupp (15-22 career record) holds a 4.02 earned run average while giving up 8.3 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Cincinnati (+110)

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