Cincinnati Reds vs Seattle Mariners Prediction, 7/22/2026 MLB Picks, Best Bets & Odds

Game: Cincinnati Reds vs Seattle Mariners

Date: Wednesday, July 22, 2026

Location: T-Mobile Park in Seattle, WA

TV: MLB.TV

Odds/Point Spread: Cincinnati (+125) Seattle (-145)

The Cincinnati Reds (45-54) are traveling to T-Mobile Park on Wednesday where they will go up against the Seattle Mariners (51-50). The line on this contest has the Reds at +125 while the Mariners are coming in at -145. The total comes in at 9. The pitchers expected to start will be Brady Singer and Emerson Hancock.

As a team, the Cincinnati Reds are knocking in 4.2 runs per game, which has them sitting at 23rd in the league. They have earned 414 runs while having a team OBP of .310. The Reds have recorded 152 two-baggers as a team and have knocked 129 balls out of the stadium. They have accrued 395 RBI's and 764 base knocks so far this year, while their average at the plate is .230. Cincinnati has a slugging percentage of .399 and have struck out 928 times, while drawing a walk on 360 occasions.

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The Reds are sitting with a team ERA of 4.60 this season (23rd in the league), and their staff has struck out 800 hitters. Reds pitchers have relinquished 134 home runs and 481 runs in total (22nd in baseball). They have walked 430 batters and their FIP comes in at 4.89 as a unit this year. Cincinnati has conceded 835 base hits (8.5 per 9 innings) and also 450 earned runs. Their strikeout to walk ratio is 1.86 and their pitching staff has earned a collective WHIP of 1.44.

Reds bullpen pitchers have come into the game with opponents on base 110 times as well as having 114 appearances in high leverage situations. The relief pitchers have a total of 51 holds so far this year (16th in the league). The Reds relief pitchers have accumulated a save percentage of 55.3% and have come into the game in 90 save situations. They have compiled 21 saves for the season and have blown 17 out of their 38 save opportunities. The relief pitchers have inherited 154 base runners so far this year and 27.9% of those runners crossing the plate. The Reds have dispatched 351 relief pitchers to the mound on the year.

The Cincinnati Reds have 2,640 putouts over the course of the season, in addition to 805 assists and 53 errors. Their fielding rate sits at .985 which is 18th in the majors, and they have turned 71 double plays. The Reds have transformed 70.3% of balls hit into play into outs out of their 7,920 innings, which has them sitting 12th in the majors.

Singer (54-65 mark in his career) has a FIP of 4.20 while facing 4,078 batters in the major leagues. He has allowed 950 base hits (9.0 hits per nine innings) and has 305 free passes. His ERA is 4.27 (451 earned runs allowed) and his WHIP is 1.319. Singer has thrown 951 innings and has earned 890 punch outs so far in his career.

The Seattle Mariners are sitting with a team OBP of .310 and a team batting average of .230 on the campaign. They have been called out on strikes on 867 instances (11th in the league) and have tallied 765 hits. Seattle has recorded 119 home runs on the season as well as 395 RBIs. The Mariners hold a team slugging percentage of .378 and they average 4.06 runs per contest (28th in baseball). They have hit 123 doubles, while getting a free base 337 times as well as putting up 410 runs.

The Mariners hold a team WHIP of 1.173 in addition to having a FIP of 3.53 as a squad on the year. They are currently ranked 11th in baseball as a pitching staff in total hits allowed with 798. The Seattle pitching staff have conceded 389 runs this season and come in with a team ERA of 3.57 (355 earned runs given up). They have earned a strikeout to walk ratio of 8.80 (871 strikeouts vs 251 bases on balls). They have conceded 95 homers and they surrender 3.92 runs per 9 innings (4th in the league).

They sit at 19th in MLB with a save percentage of 60.5%, and they have dispatched 301 relief pitchers to the mound on the year. Their relievers have stepped onto the hill 105 times in high leverage situations in addition to 70 occasions with base runners. Sitting with 95 save situations, the Mariners have compiled 56 holds and 15 blown saves. Seattle has had relievers enter the contest in 38 save chances and they have recorded 23 saves. Seattle bullpen pitchers hold an inherited score percentage of 29.2% out of their 96 inherited runners.

In 8,049 innings played, the Mariners have accumulated a defensive efficiency of 69.7% (19th in MLB). The Seattle Mariners have turned 87 double plays and own a fielding percentage of .985 (17th in MLB). The Mariners have racked up 821 assists, 52 errors and have accumulated 2,683 putouts so far this year.

Hancock (14-13 career record) has earned a 4.20 ERA while surrendering 8.4 hits per nine innings. His strikeout to walk ratio is 2.60 and he has faced 1,090 batters so far in his career. He has allowed 122 ER's while earning a WHIP of 1.228 and being the owner of a FIP of 4.1. In his MLB career, Hancock has allowed 243 hits while accumulating 203 K's in 261 innings pitched.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Seattle (-145)

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