Cincinnati Reds vs St. Louis Cardinals Prediction, 6/5/2026 MLB Picks, Best Bets & Odds

Game: Cincinnati Reds vs St. Louis Cardinals

Date: Friday, June 5, 2026

Location: Busch Stadium in St. Louis, MO

TV: Cardinals.TV

Odds/Point Spread: Cincinnati (-160) St. Louis (+132)

The St. Louis Cardinals (31-28) will go up against the Cincinnati Reds (31-29) at Busch Stadium on Friday. The moneyline on this game has the Reds at -160 while the Cardinals are priced at +132. The total comes in at 8.5. The starting pitchers will be Brady Singer and Kyle Leahy.

As a unit, the Cincinnati Reds are putting up 4.4 runs per outing, which has them sitting at 14th in baseball. They have earned a total of 262 runs scored and have an OBP of .312. The Reds have tallied 95 two-baggers as a squad and have knocked 76 balls out of the stadium. They have amassed 247 RBI's as well as 460 base knocks so far this year, while their average at the plate sits at .229. Cincinnati has a slugging % of .395 and have been called out on strikes 562 times, while taking a walk on 233 occasions.

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The Reds have a team ERA of 4.76 on the season (27th in baseball), and their staff has struck out 463 hitters. Reds pitchers have surrendered 86 home runs and also 300 runs in total (23rd in the league). They have walked 276 opposing players and their FIP is 5.15 as a team on the year. Cincinnati has allowed 506 base hits (8.5 per 9 innings) and 284 earned runs. They have accumulated a K/BB ratio of 1.68 and the pitching staff sits with a WHIP of 1.46.

The Reds bullpen have a save percentage of 58.3% and have entered the game in 66 save situations. They have accumulated 14 saves over the course of the season and have blown 10 out of their 24 chances to get a save. The relief pitchers have inherited 86 runners for the season with 29.1% of them crossing home plate. Reds bullpen pitchers have entered the contest with players on base 63 times and also have had 65 appearances in high leverage situations. The Reds have dispatched 221 relievers to the hill this season. The relief pitchers have notched 41 holds this year (6th in the league).

The Reds have transformed 71.2% of baseballs in play into outs out of their 4,836 innings on the field, which has them sitting at 8th in MLB. The Cincinnati Reds have notched a total of 1,612 putouts on the year, as well as 501 assists and 25 errors. Their fielding percentage is currently at .988 which is 8th in MLB, and have a total of 51 double plays.

Singer has taken the hill for 906 innings and has earned 844 strikeouts thus far in his career. His earned run average is 4.34 (437 ER's allowed) and his career WHIP is 1.330. He has given up 915 base hits (9.1 hits per 9 innings) and has 290 walks. Singer (52-61 career mark) is the owner of a FIP of 4.28 and he has gone up against 3,888 opposing batters in the major leagues.

The Cardinals hold a team SLG% of .382 and they tally 4.27 runs per game (18th in the league). They have 81 two-baggers, while walking 192 times as well as putting up 252 runs. St. Louis is sitting with 65 long balls so far this season to go along with 245 runs batted in. They have struck out on 479 occasions (24th in baseball) and have earned a total of 473 base knocks. The St. Louis Cardinals have accounted for an OBP of .316 and a batting average of .239 this season.

The St. Louis pitching staff have relinquished 266 runs for the season while holding an ERA of 4.17 (246 earned runs yielded). They have surrendered 61 homers and they allow 4.51 runs per 9 innings (18th in MLB). The Cardinals have a team WHIP of 1.361 and have a FIP of 4.21 as a squad so far this season. Their K/BB ratio comes in at 7.70 (457 strikeouts vs 208 bases on balls). They have a ranking of 23rd in the league as a pitching staff in total hits allowed with 515.

With 77 save situations, the Cardinals have earned 46 holds and also 10 blown saves. St. Louis has had bullpen pitchers enter the game in 29 save opportunities and they have walked away with 19 saves. St. Louis relievers hold an inherited score percentage of 35.1% out of their 94 inherited base runners. Their relievers have stepped onto the mound 73 times in high leverage situations and on 66 occasions with base runners. They rank 13th in baseball with a save rate of 65.5%, and they have sent 208 bullpen pitchers to the mound for the year.

The St. Louis Cardinals have turned 57 double plays and have earned a fielding percentage of .986 (17th in the majors). The Cardinals have racked up 561 assists, 30 errors and have amassed 1,595 putouts so far this season. In their 4,785 innings played, the Cardinals have earned a efficiency on defense of 69.1% (25th in MLB).

Leahy (10-7 career mark) is the owner of a 3.82 earned run average while giving up 8.8 hits per nine innings. He has a strikeout to walk ratio of 2.48 and he has faced 819 batters in his pro baseball career. He has allowed 82 ER's while earning a WHIP of 1.310 and being the owner of a FIP of 3.8. Thus far in his career, Leahy has given up 188 base knocks while he has tallied 161 strikeouts in 193 frames.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Cincinnati (-160)

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