Cincinnati Reds vs St. Louis Cardinals Prediction, 6/6/2026 MLB Picks, Best Bets & Odds

Game: Cincinnati Reds vs St. Louis Cardinals

Date: Saturday, June 6, 2026

Location: Busch Stadium in St. Louis, MO

TV: Cardinals.TV

Odds/Point Spread: Cincinnati (-122) St. Louis (+102)

The St. Louis Cardinals (32-28) will go up against the Cincinnati Reds (31-30) at Busch Stadium on Saturday. The moneyline on this game has Cincinnati at -122 and St. Louis is priced at +102. The over/under is set at 9. The pitchers taking the mound will be Nick Lodolo and Matthew Liberatore.

As a squad, the Cincinnati Reds are scoring 4.3 runs per outing, which has them sitting at 15th in baseball. They have earned 264 runs scored and hold an OBP of .312. The Reds have accrued 98 doubles as a team and have hit 77 baseballs out of the park. They have recorded 249 RBI's in addition to 468 base knocks for the year, while their team batting average is at .229. Cincinnati is slugging .395 and have struck out 573 times, while drawing a walk on 236 occasions.

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The Reds have compiled a team ERA of 4.76 over the course of the season (27th in the league), and their staff has struck out 476 batters. Reds pitchers have given up 88 home runs and 305 runs in total (24th in MLB). Their pitching staff has walked 279 opposing batters and their FIP comes in at 5.14 as a unit over the course of the season. Cincinnati has surrendered 515 base hits (8.5 per 9 innings) as well as 289 earned runs. They have earned a K/BB ratio of 1.71 and their pitching staff holds a collective WHIP of 1.45.

Reds bullpen pitchers have entered the contest with runners on base 64 times and also have had 67 appearances in high leverage situations. The bullpen have a total of 41 holds for the season (6th in the league). The Reds relievers have compiled a save rate of 58.3% and have come into the game in 66 save situations. They have earned 14 saves on the year and have blown 10 of 24 save opportunities. The relievers have inherited 87 runners so far this year and 28.7% of them earned a run for their team. The Reds have dispatched 225 relief pitchers to the hill this season.

The Reds have transformed 71.2% of baseballs in play into outs out of 4,917 innings on the field, which has them sitting 9th in the majors. The Cincinnati Reds have accumulated 1,639 putouts thus far, as well as 504 assists and 26 errors. Their fielding percentage is currently at .988 which is 7th in baseball, and have a total of 51 double plays.

Lodolo has taken the mound for 436 innings and is sitting with 478 punch outs during his pro baseball career. Lodolo (26-23 career win-loss mark) has a FIP of 4.08 while going up against 1,862 opposing hitters during his time in the majors. His earned run average is 4.15 (201 ER's allowed) and his career WHIP is 1.224. He has conceded 404 hits (8.3 hits per 9 innings) and has had 130 free passes.

St. Louis has recorded 65 home runs so far this season and 250 runs batted in. They have put up 84 two-baggers, while getting a free base 195 times as well as putting up 257 runs. The St. Louis Cardinals have an OBP of .317 as well as a batting average of .240 over the course of the season. The Cardinals have a team SLG% of .384 and they score 4.28 runs per contest (17th in MLB). They have been rung up on 487 occasions (23rd in MLB) and have notched a total of 484 base hits.

The Cardinals hold a team WHIP of 1.357 and are the owners of a FIP of 4.20 as a team on the year. They come in at 24th in MLB as a pitching staff in total hits given up with 521. The St. Louis pitching staff have given up 269 runs on the year while having an ERA of 4.15 (249 earned runs relinquished). Their strikeout to walk ratio sits at 7.70 (465 strikeouts vs 212 walks). They have surrendered 61 long balls and they allow 4.48 runs per 9 innings (15th in baseball).

With 80 save situations, the Cardinals have accumulated 48 holds in addition to 10 blown saves. St. Louis has called on bullpen pitchers to step onto the mound in 30 save chances and they have recorded 20 saves. St. Louis relievers hold an inherited score rate of 34.0% of 97 inherited runners. Their bullpen pitchers have come in 75 times in high leverage situations and also on 68 occasions with runners on. They are ranked 13th in baseball holding a save percentage of 66.7%, and they have sent 211 relievers onto the diamond so far this season.

The St. Louis Cardinals have gotten 58 double plays and hold a fielding percentage of .986 (18th in baseball). The Cardinals have recorded 566 assists, 31 errors and have accounted for 1,622 putouts so far this season. In 4,866 innings played, the Cardinals have earned a defensive efficiency of 69.2% (24th in pro baseball).

Liberatore (19-27 career record) has a 4.59 ERA and has conceded 9.5 hits per nine innings. He has a K/BB ratio of 2.46 and he has gone up against 1,710 opposing batters during his MLB career. He has allowed a total of 202 earned runs while holding a WHIP of 1.391 and a FIP of 4.5. In his MLB career, Liberatore has allowed 417 hits while he has earned 329 punch outs in 396 frames.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Cincinnati (-122)

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