Cincinnati Reds vs Tampa Bay Rays Prediction, 4/22/2026 MLB Picks, Best Bets & Odds

Game: Cincinnati Reds vs Tampa Bay Rays

Date: Wednesday, April 22, 2026

Location: Tropicana Field in St. Petersburg, FL

TV: MLB.TV

Odds/Point Spread: Cincinnati (-160) Tampa Bay (+132)

Tropicana Field is the site where the Tampa Bay Rays (12-10) will meet the Cincinnati Reds (15-8) on Wednesday. The odds on this game have the Reds at -160 and the Rays are at +132. The total is 8. The pitchers taking the mound will be Brandon Williamson and Nick Martinez.

Cincinnati is slugging .332 and have struck out 213 times, while being walked on 93 occasions. They have accrued 75 RBI's and 154 hits on the campaign, and their team batting average sits at .204. The Reds have tallied 29 two-baggers as a squad and have knocked 22 baseballs out of the park. They have tallied 84 runs scored and have an on-base percentage of .296. As a squad, the Cincinnati Reds are notching 3.7 runs per contest, which has them at 26th in baseball.

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They have a K/BB ratio of 1.68 and the pitching staff holds a collective WHIP of 1.34. Reds pitchers have allowed 17 long balls and also 87 runs in total (8th in MLB). Cincinnati has surrendered 176 base hits (7.6 per 9 innings) in addition to 78 earned runs. The Reds have compiled a team ERA of 3.36 on the year (4th in MLB), and they have rung up 175 batters. Their pitching staff has walked 104 batters and their FIP comes in at 4.14 as a team over the course of the season.

The Reds have dispatched 87 relievers to the hill for the year. The relievers have inherited 37 base runners for the season and 24.3% of those players ended up crossing the plate. The relievers have a total of 20 holds on the year (2nd in baseball). Reds relief pitchers have stepped onto the hill with runners on 28 times as well as having 36 appearances in high leverage situations. They have compiled 10 saves so far this season and have blown 3 of their 13 chances to save the game. The Reds relievers have earned a save percentage of 76.9% and have come into the game in 34 save situations.

The Reds have converted 71.8% of balls hit into play into outs in their 1,881 innings on the field, ranking them 4th in pro baseball. The Chicago White Sox have amassed 627 putouts for the season, in addition to 193 assists and 11 errors. Their fielding rate is currently at .987 which has them sitting 12th in professional baseball, and have a total of 22 double plays.

Williamson (7-6 career record) has earned a FIP of 4.34 and he has faced 640 opposing batters during his time in the major leagues. He has given up 136 hits (8.1 hits per nine innings) and has had 57 walks. His earned run average is 4.40 (74 ER's allowed) and his career WHIP is 1.276. Williamson has taken the mound for 151 innings and has totaled 122 strikeouts so far in his pro baseball career.

The Tampa Bay Rays have tallied an OBP of .329 and a batting average of .256 on the season. They have struck out on 160 occasions (29th in MLB) and have notched a total of 197 hits. Tampa Bay has accumulated 18 HRs so far this season as well as 98 RBIs. The Rays hold a slugging percentage of .377 and they earn 4.73 runs per contest (12th in baseball). They have notched 31 doubles, while walking 75 times as well as scoring 104 runs.

The Rays have a team WHIP of 1.272 and have a FIP of 4.46 as a squad this season. Their strikeout to walk ratio sits at 8.00 (176 strikeouts vs 79 free passes). They are currently ranked 12th in baseball as a staff in total hits conceded with 173. They have yielded 28 homers and they yield 5.22 runs per 9 innings (26th in baseball). The Tampa Bay pitching staff have allowed 115 runs on the campaign while holding an ERA of 4.54 (100 earned runs relinquished).

Tampa Bay bullpen pitchers have an inherited score percentage of 41.4% out of their 29 inherited base runners. Their relievers have come in 30 times in high leverage situations in addition to 23 occasions with runners on base. With 27 save situations, the Rays have recorded 15 holds and also 4 blown saves. They are currently ranked 11th in baseball holding a save percentage of 66.7%, and they have sent 72 relief pitchers to the hill so far this year.

Out of their 1,785 innings on the diamond, the Rays have accumulated a defensive efficiency of 71.7% (5th in pro baseball). The Tampa Bay Rays have gotten 10 double plays and own a fielding percentage of .974 (29th in MLB). The Rays have accrued 169 assists, 20 errors and have accumulated 595 putouts during this campaign.

During his career, Martinez has given up 955 base hits while he has accumulated 684 punch outs in 962 innings. He has allowed 440 earned runs while holding a WHIP of 1.300 and a FIP of 4.1. He has a strikeout to walk ratio of 2.31 and he has faced 4,079 opposing hitters during his MLB career. Martinez (48-60 win-loss mark in his career) has earned a 4.12 earned run average while allowing 8.9 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Cincinnati (-160)

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