Cincinnati Reds vs Toronto Blue Jays Prediction, 9/25/2026 MLB Picks, Best Bets & Odds

Game: Cincinnati Reds vs Toronto Blue Jays

Date: Friday, September 25, 2026

Location: Rogers Centre in Toronto, ON

TV: Sportsnet

Odds/Point Spread: Cincinnati (+120) Toronto (-144)

The Cincinnati Reds (73-84) are traveling to Rogers Centre on Friday where they will try to defeat the Toronto Blue Jays (77-80). The moneyline on this contest has the Reds at +120 and the Blue Jays are coming in at -144. The betting total comes in at 8. The pitchers taking the mound are Nick Lodolo and Jose Soriano.

Cincinnati is slugging .394 and have been called out on strikes 1,492 times, while taking a walk on 546 occasions. They have 616 RBI's as well as 1,194 hits for the year, while their batting average is .229. The Reds have earned 213 doubles as a unit and have knocked 207 baseballs out of the stadium. They have tallied 646 runs scored while holding a team on-base percentage of .306. As a unit, the Cincinnati Reds are recording 4.1 runs per contest, which has them at 27th in baseball.

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Their strikeout to walk ratio sits at 1.94 and their pitching staff has earned a collective WHIP of 1.45. Reds pitchers have relinquished 209 home runs and 805 runs in total (28th in MLB). Cincinnati has conceded 1,362 hits (8.8 per 9 innings) as well as 751 earned runs. The Reds are sitting with a team earned run average of 4.86 for the year (28th in the league), and the staff has rung up 1,261 hitters. They have walked 651 players from the other team and their FIP is 4.82 as a squad on the campaign.

The Reds have dispatched 557 relievers to the hill this season. The relievers have inherited 240 base runners this season with 27.1% of those runners earned a run for their team. The bullpen have notched 86 holds on the campaign (12th in baseball). Reds bullpen pitchers have entered the game with players on base 160 times as well as having 181 appearances in high leverage situations. They have recorded 41 saves on the year and have blown 22 of their 63 save chances. The Reds bullpen have compiled a save rate of 65.1% and have come into the game in 153 save situations.

The Cincinnati Reds have earned 4,170 putouts at this point in the season, as well as 1,260 assists and 87 errors. Their fielding percentage sits at .984 which has them ranked 20th in MLB, and have 111 double plays. The Reds have turned 69.5% of baseballs in play into outs out of their 12,510 innings, which has them ranked 19th in baseball.

Lodolo has thrown 512 innings and has earned 536 punch outs during his pro baseball career. His earned run average is 4.27 (243 earned runs allowed) and he has a WHIP of 1.265. He has allowed 487 hits (8.6 hits per nine innings) and has 161 walks. Lodolo (27-28 mark in his career) is the owner of a FIP of 4.20 while he has faced 2,204 batters in the major leagues.

Toronto has hit 149 home runs on the year as well as 601 RBIs. They have recorded 247 two-baggers, while walking 444 times and putting up 632 runs. The Toronto Blue Jays are sitting with a team on-base percentage of .310 and a team batting average of .248 this year. The Blue Jays hold a slugging % of .382 and they average 4.03 runs per contest (30th in baseball). They have been called out on strikes on 1,116 instances (29th in the league) and have totaled 1,311 base hits.

The Toronto pitching staff have given up 675 runs on the year while holding a team ERA of 3.92 (606 earned runs surrendered). They have surrendered 163 long balls and they relinquish 4.36 runs per 9 innings (11th in baseball). The Blue Jays hold a team WHIP of 1.301 in addition to having a FIP of 4.00 as a team this year. They currently have a K/BB ratio of 8.80 (1,365 strikeouts against 581 walks). They have a ranking of 7th in baseball as a staff in total hits allowed with 1,231.

Toronto relievers have an inherited score rate of 25.9% out of their 247 inherited base runners. Their relief pitchers have stepped onto the hill 190 times in high leverage situations and also on 169 occasions with base runners. With 177 save situations, the Blue Jays have amassed 104 holds and also 17 blown saves. They sit at 4th in MLB holding a save rate of 75.0%, and they have sent 590 bullpen pitchers onto the diamond this year.

The Toronto Blue Jays have turned 106 double plays and have a fielding rate of .983 (26th in the majors). The Blue Jays have accrued 1,318 assists, 96 errors and have accounted for 4,179 putouts for the season. In 12,537 innings on the diamond, the Blue Jays have accumulated a defensive efficiency of 70.1% (13th in pro baseball).

So far in his pro baseball career, Soriano has surrendered 332 hits while he has accumulated 345 K's in 375 innings. He has given up 167 earned runs while earning a WHIP of 1.317 and being the owner of a FIP of 3.9. His strikeout to walk ratio is 2.13 and he has gone up against 1,595 opposing hitters thus far in his career. Soriano (20-23 career win-loss mark) has a 4.01 ERA and has given up 8.0 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Cincinnati (+120)

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