Cleveland Guardians vs Boston Red Sox Prediction, 9/23/2026 MLB Picks, Best Bets & Odds

Game: Cleveland Guardians vs Boston Red Sox

Date: Wednesday, September 23, 2026

Location: Fenway Park in Boston, MA

TV: NESN

Odds/Point Spread: Cleveland (+125) Boston (-150)

Fenway Park is the location where the Boston Red Sox (84-72) will try to defeat the Cleveland Guardians (81-75) on Wednesday. The odds on this game have the Guardians at +125 while the Red Sox are coming in at -150. The over/under has been set at 8. The starting pitchers will be Foster Griffin and Sonny Gray.

As a team, the Cleveland Guardians are scoring 4.2 runs per game, which has them at 26th in the league. They have accumulated 649 runs while holding a team on-base percentage of .315. The Guardians have tallied 241 doubles as a team and have hit 152 baseballs out of the stadium. They have accounted for 622 RBI's as well as 1,238 base knocks on the campaign, while their team batting average is at .238. Cleveland is slugging .377 and have been called out on strikes 1,233 times, while being walked on 548 occasions.

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The Guardians hold a team earned run average of 3.78 on the campaign (8th in the league), and they have rung up 1,476 hitters. Guardians pitchers have surrendered 169 home runs and also 647 total runs (8th in the league). They have walked 513 opposing batters and their FIP comes in at 3.82 as a team for the season. Cleveland has surrendered 1,232 base hits (8.0 per 9 innings) and also 582 earned runs. Their strikeout to walk ratio sits at 2.88 and the pitching staff has a team WHIP of 1.26.

The Guardians relief pitchers have earned a save percentage of 73.3% and have entered the game in 170 save situations. They have tallied 44 saves for the season and have blown 16 of their 60 chances to get a save. The relief pitchers have inherited 257 base runners on the campaign with 28.4% of them crossing home plate. Guardians pitchers have come into the game with opponents on base 162 times and also have had 166 appearances in high leverage situations. The Guardians have sent 532 relievers to the mound this season. The relief pitchers have notched 108 holds over the course of the season (2nd in the league).

The Guardians have turned 69.3% of balls in play into outs in their 12,471 innings on the field, which has them sitting 22nd in MLB. The Cleveland Guardians have 4,157 putouts this year, in addition to 1,213 assists and 81 errors. Their fielding percentage sits at .985 which puts them in 17th in baseball, and they have turned 101 double plays.

Griffin (4-2 record in his career) sits with a FIP of 5.90 while he has faced 207 opposing batters in the major leagues. He has surrendered 52 hits (10.4 hits per 9 innings) and has 20 walks. His earned run average is 5.99 (30 ER's allowed) and his WHIP is 1.596. Griffin has taken the ball for 45 innings and has accumulated 40 K's so far in his career.

Boston has hit 161 home runs for the season to go along with 648 runs batted in. They have tallied 277 doubles, while taking a walk 497 times and scoring 678 runs. The Boston Red Sox have earned a team on-base percentage of .320 and a team batting average of .246 this season. The Red Sox have a team slugging % of .401 and they are recording 4.35 runs per outing (20th in MLB). They have been called out on strikes on 1,271 occasions (20th in the league) and have tallied 1,286 hits.

The Boston pitching staff have relinquished 598 runs for the season and come in with a team ERA of 3.59 (553 earned runs given up). They have allowed 150 home runs and they allow 3.88 runs per 9 innings (4th in MLB). The Red Sox hold a team WHIP of 1.235 with a FIP of 3.67 as a staff on the season. Their strikeout to walk ratio is 8.80 (1,352 strikeouts against 453 free passes). They are sitting at 14th in baseball as a staff in total hits allowed with 1,259.

They are ranked 2nd in the league holding a save percentage of 75.9%, and they have dispatched 472 bullpen pitchers to the hill this season. Their relievers have stepped onto the mound 142 times in high leverage situations in addition to 121 occasions with runners on. Sitting with 152 save situations, the Red Sox have 92 holds in addition to 14 blown saves. Boston has called on bullpen pitchers to enter the contest in 58 save opportunities and they have walked away with 44 saves. Boston bullpen pitchers hold an inherited score percentage of 29.4% of 160 inherited runners.

In 12,474 innings on the field, the Red Sox have earned a efficiency on defense of 69.4% (21st in pro baseball). The Boston Red Sox have gotten 118 double plays and have accounted for a fielding rate of .986 (15th in baseball). The Red Sox have accrued 1,361 assists, 79 errors and have amassed 4,158 putouts this year.

Gray (142-107 career mark) has a 3.52 ERA while giving up 7.9 hits per 9 innings. His K/BB ratio is 3.11 and he has faced 8,613 opposing hitters in his career. He has surrendered 814 ER's while earning a WHIP of 1.194 and being the owner of a FIP of 3.5. In his MLB career, Gray has surrendered 1,819 base hits while tallying 2,071 punch outs in 2,081 innings pitched.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Cleveland (+125)

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