Cleveland Guardians vs Boston Red Sox Prediction, 9/24/2026 MLB Picks, Best Bets & Odds

Game: Cleveland Guardians vs Boston Red Sox

Date: Thursday, September 24, 2026

Location: Fenway Park in Boston, MA

TV: NESN

Odds/Point Spread: Cleveland (+110) Boston (-132)

The Cleveland Guardians (82-75) are headed to Fenway Park on Thursday where they will take on the Boston Red Sox (84-73). The odds on this game have the Guardians at +110 and the Red Sox are sitting at -132. The over/under has been set at 8.5. The expected starting pitchers are Tanner Bibee and Ranger Suarez.

Cleveland has a slugging percentage of .377 and have been called out on strikes 1,242 times, while being walked on 552 occasions. They have 624 RBI's and 1,250 hits on the year, while their average at the plate sits at .239. The Guardians have hit 243 doubles as a team and have hit 152 baseballs out of the park. They have a total of 652 runs scored and hold an on-base percentage of .316. As a squad, the Cleveland Guardians are compiling 4.2 runs per outing, which has them sitting at 26th in MLB.

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Their strikeout to walk ratio sits at 2.88 and the pitching staff holds a WHIP of 1.26. Guardians pitchers have allowed 170 long balls and 649 total runs (8th in baseball). Cleveland has allowed 1,240 base hits (8.0 per 9 innings) and also 584 earned runs. The Guardians have an ERA of 3.77 on the year (8th in the league), and the staff has struck out 1,488 hitters. They have walked 517 opposing players and their FIP comes in at 3.82 as a unit this year.

The Guardians bullpen have recorded a save percentage of 72.6% and have entered the game in 175 save situations. They have compiled 45 saves so far this year and have not converted 17 of 62 save opportunities. The bullpen pitchers have inherited 258 runners this season and 28.3% of those runners ended up scoring. Guardians bullpen pitchers have stepped onto the hill with runners on 163 times in addition to having 171 appearances in high leverage situations. The Guardians have sent 537 relief pitchers to the hill on the season. The relievers have earned 111 holds on the season (2nd in baseball).

The Cleveland Guardians have amassed 4,184 putouts at this point in the season, as well as 1,220 assists and 81 errors. Their fielding percentage is holding at .985 which puts them in 17th in professional baseball, and have 102 double plays. The Guardians have converted 69.3% of baseballs in play into outs in their 12,552 innings, which has them sitting at 21st in the majors.

Bibee has thrown 680 innings and has accumulated 632 punch outs in his career. Bibee (40-38 career record) sits with a FIP of 3.75 and he has gone up against 2,812 opposing batters in the major leagues. His earned run average is 3.81 (288 earned runs allowed) and he has a WHIP of 1.187. He has surrendered 610 hits (8.1 hits per nine innings) and has 197 free passes.

Boston is sitting with 162 HRs for the season and 650 runs batted in. They have hit 281 doubles, while walking 501 times as well as notching 680 runs. The Boston Red Sox have accumulated an OBP of .320 as well as a team batting average of .246 this year. The Red Sox have a team slugging % of .401 and they are recording 4.33 runs per game (20th in MLB). They have struck out on 1,283 occasions (20th in MLB) and have accounted for 1,294 hits.

The Red Sox have a WHIP of 1.239 and are the owners of a FIP of 3.67 as a squad over the course of the season. They currently have a strikeout to walk ratio of 8.80 (1,361 strikeouts vs 457 bases on balls). They are sitting at 14th in baseball as a staff in total hits given up with 1,271. They have given up 150 homers and they surrender 3.88 runs per 9 innings (3rd in MLB). The Boston pitching staff have allowed 601 runs so far this season while having a team ERA of 3.59 (556 earned runs surrendered).

With 152 save situations, the Red Sox have earned 92 holds in addition to 14 blown saves. Boston has called on bullpen pitchers to step onto the hill in 58 save chances and they have tallied 44 saves. Boston bullpen pitchers hold an inherited score rate of 29.2% of 161 inherited runners. Their relief pitchers have taken the field 143 times in high leverage situations and also on 122 occasions with runners on base. They rank 2nd in the league with a save rate of 75.9%, and they have sent 475 relief pitchers onto the field this year.

Out of their 12,555 innings played, the Red Sox hold a efficiency on defense of 69.3% (22nd in MLB). The Boston Red Sox have turned 119 double plays and have accounted for a fielding rate of .986 (15th in professional baseball). The Red Sox have racked up 1,371 assists, 80 errors and have notched a total of 4,185 putouts for the year.

In his MLB career, Suarez has surrendered 855 hits while totaling 840 K's in 905 innings pitched. He has allowed 338 ER's while earning a WHIP of 1.260 and having a FIP of 3.3. He has a K/BB ratio of 2.95 and he has gone up against 3,790 hitters during his pro baseball career. Suarez (61-41 win-loss mark in his career) has a 3.36 ERA while allowing 8.5 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Cleveland (+110)

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