Cleveland Guardians vs Chicago White Sox Prediction, 10/7/2026 MLB Picks, Best Bets & Odds

Game: Cleveland Guardians vs Chicago White Sox

Date: Wednesday, October 7, 2026

Location: Rate Field in Chicago, IL

TV: TBS

Odds/Point Spread: Cleveland (+100) Chicago (-120)

The Cleveland Guardians (85-77) are hitting the road to Rate Field on Wednesday where they will go up against the Chicago White Sox (84-78) in Game 3 of the ALDS. The White Sox lead 2-0. The odds on this game have Cleveland at +100 while Chicago opens at -120. The over/under is 8. The men taking the mound are Daniel Espino and Sean Newcomb.

Cleveland is slugging .380 and have been called out on strikes 1,271 times, while drawing a walk on 574 occasions. They have recorded 650 runs batted in in addition to 1,291 hits on the year, and their average at the plate is sitting at .239. The Guardians have accrued 249 two-baggers as a squad and have smacked 162 baseballs out of the park. They have a total of 678 runs scored and hold an on-base percentage of .316. As a team, the Cleveland Guardians are recording 4.2 runs per game, which has them sitting at 24th in the league.

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They have a K/BB ratio of 2.89 and their pitching staff has recorded a WHIP of 1.26. Guardians pitchers have surrendered 175 home runs in addition to 667 total runs (8th in the league). Cleveland has surrendered 1,286 hits (8.1 per 9 innings) in addition to 602 earned runs. The Guardians are sitting with a team ERA of 3.77 on the season (8th in baseball), and the staff has rung up 1,530 batters. Their pitching staff has walked 530 opposing players and their FIP is 3.82 as a squad over the course of the season.

The Guardians relief pitchers have recorded a save percentage of 71.9% and have stepped onto the mound in 183 save situations. They have recorded 46 saves so far this year and have blown 18 out of their 64 save chances. The relievers have inherited 261 runners this season with 28.4% of those runners crossing the plate. Guardians bullpen pitchers have come into the game with opponents on base 166 times and also have had 178 appearances in high leverage situations. The Guardians have sent 555 relievers to the hill for the year. The bullpen have a total of 117 holds for the year (1st in baseball).

The Guardians have converted 69.1% of balls in play into outs in their 12,939 innings, which has them ranked 23rd in the majors. The Cleveland Guardians have notched a total of 4,313 putouts on the year, as well as 1,262 assists and 86 errors. Their fielding percentage is holding steady at .985 which puts them in 17th in professional baseball, and they have turned 108 double plays.

Espino has taken the ball for 15 innings and has earned 25 strikeouts so far in his MLB career. Espino (0-0 win-loss mark in his career) holds a FIP of 4.11 while he has gone up against 65 batters during his time in the major leagues. His ERA is 4.17 (7 ER's allowed) and he has a career WHIP of 1.258. He has surrendered 12 hits (7.2 hits per 9 innings) and has 7 walks.

The Chicago White Sox have earned a team on-base percentage of .320 in addition to a team batting average of .236 so far this year. They have struck out on 1,494 occasions (5th in the league) and have notched a total of 1,282 hits. Chicago has knocked in 211 HRs this season to go along with 740 RBIs. The White Sox hold a slugging percentage of .406 and they average 4.79 runs per game (5th in MLB). They have 252 doubles, while taking a walk 589 times and putting up 776 runs.

The Chicago pitching staff have conceded 720 runs on the campaign while holding an ERA of 4.12 (660 earned runs relinquished). They have conceded 180 homers and they allow 4.50 runs per 9 innings (14th in baseball). The White Sox have a WHIP of 1.311 and are the owners of a FIP of 4.25 as a unit for the year. They have earned a K/BB ratio of 8.40 (1,337 strikeouts vs 571 walks). They come in at 16th in the league as a pitching staff in total hits surrendered with 1,317.

Sitting with 137 save situations, the White Sox have amassed 63 holds and 30 blown saves. Chicago has had relief pitchers step onto the hill in 71 save opportunities and they have tallied 41 saves. Chicago relievers hold an inherited score percentage of 30.5% of 269 inherited runners. Their bullpen pitchers have taken the field 156 times in high leverage situations and on 183 occasions with base runners. They sit at 23rd in the league with a save percentage of 57.7%, and they have dispatched 541 relief pitchers onto the field so far this year.

Out of their 12,966 innings on the diamond, the White Sox hold a defensive efficiency of 70.2% (12th in professional baseball). The Chicago White Sox have turned 115 double plays and have notched a fielding percentage of .986 (16th in MLB). The White Sox have racked up 1,318 assists, 82 errors and have a tally of 4,322 putouts over the course of the season.

So far in his career, Newcomb has given up 563 hits while he has earned 613 K's in 613 innings pitched. Newcomb (32-35 career win-loss record) is the owner of a 4.04 ERA and has allowed 8.3 hits per 9 innings. He has conceded 275 earned runs while earning a WHIP of 1.409 and being the owner of a FIP of 4.0. He has a strikeout to walk ratio of 2.04 and he has faced 2,668 batters so far in his career.

Who will win tonight's MLB game against the spread or moneyline?

Tony Sink's Pick: Take Cleveland (+100)

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