Cleveland Guardians vs Chicago White Sox Prediction, 6/22/2026 MLB Picks, Best Bets & Odds

Game: Cleveland Guardians vs Chicago White Sox

Date: Monday, June 22, 2026

Location: Rate Field in Chicago, IL

TV: Chicago Sports Network

Odds/Point Spread: Cleveland (-150) Chicago (+125)

The Cleveland Guardians (40-36) are on their way to Rate Field on Monday where they will attempt to beat the Chicago White Sox (39-35). The line on this contest has Cleveland at -150 and Chicago is priced at +125. The total is set at 9. The expected starting pitchers are Gavin Williams and Anthony Kay.

The Guardians have accumulated 125 two-baggers as a squad and have smacked 71 balls out of the park. Cleveland is slugging .370 and have been called out on strikes 606 times, while taking a walk on 293 occasions. As a squad, the Cleveland Guardians are recording 4.0 runs per game, which is 28th in the league. They have compiled 287 runs batted in and 569 hits on the year, while their team batting average comes in at .229. They have notched a total of 301 runs scored while holding a team OBP of .314.

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The Guardians have an ERA of 3.85 for the season (6th in MLB), and the staff has struck out 696 hitters. Guardians pitchers have conceded 90 long balls in addition to 314 runs in total (10th in the league). Their pitching staff has walked 254 players from the other team and their FIP comes in at 4.01 as a team so far this year. Cleveland has given up 598 base knocks (8.0 per 9 innings) in addition to 287 earned runs. Their strikeout to walk ratio sits at 2.74 and their pitching staff holds a collective WHIP of 1.27.

The Guardians have sent 248 relievers to the hill on the year. The relief pitchers have inherited 106 base runners this year and 27.4% of those runners crossing home plate. The bullpen have racked up 66 holds over the course of the season (1st in the league). Guardians relief pitchers have entered the contest with runners on 69 times as well as having 93 appearances in high leverage situations. They have 27 saves so far this year and have blown 7 of their 34 chances to save the game. The Guardians relief pitchers have recorded a save percentage of 79.4% and have come into the game in 101 save situations.

The Cleveland Guardians have 2,014 putouts thus far, as well as 600 assists and 36 errors. Their fielding percentage is currently at .986 which has them ranked 17th in baseball, and have a total of 55 double plays. The Guardians have converted 69.9% of balls in play into outs in their 6,042 innings, ranking them 17th in the majors.

Williams has taken the mound for 416 innings and has earned 436 punch outs so far in his MLB career. Williams (27-24 win-loss record in his career) sits with a FIP of 3.56 while facing 1,750 batters in the majors. His earned run average is 3.61 (167 earned runs allowed) and his WHIP is 1.258. He has surrendered 342 hits (7.4 hits per nine innings) and has 182 walks.

The Chicago White Sox have tallied a team on-base percentage of .322 in addition to a batting average of .239 so far this year. They have struck out on 678 instances (5th in the league) and have accounted for 588 hits. Chicago has accumulated 104 home runs this year as well as 332 runs batted in. The White Sox have a SLG% of .414 and they are earning 4.70 runs per contest (9th in the league). They have 102 two-baggers, while taking a walk 259 times as well as scoring 348 runs.

The Chicago pitching staff have allowed 348 runs this year while having a team ERA of 4.43 (322 earned runs allowed). They have given up 86 homers and they concede 4.79 runs per 9 innings (19th in the league). The White Sox have a team WHIP of 1.333 and have a FIP of 4.44 as a unit for the year. Their K/BB ratio is 8.30 (605 strikeouts vs 280 free passes). They sit at 9th in MLB as a pitching staff in total hits conceded with 592.

With 57 save situations, the White Sox have 24 holds in addition to 12 blown saves. Chicago has had bullpen pitchers step onto the mound in 33 save opportunities and they have come away with 21 saves. Chicago relief pitchers hold an inherited score rate of 31.1% out of 119 inherited runners. Their bullpen pitchers have come in 67 times in high leverage situations and on 80 occasions with runners on base. They are ranked 16th in baseball with a save rate of 63.6%, and they have sent 251 relievers to the hill on the season.

The Chicago White Sox have turned 52 double plays and own a fielding percentage of .986 (18th in pro baseball). The White Sox have accrued 634 assists, 37 errors and have earned a total of 1,964 putouts over the course of the season. Out of their 5,892 innings on the field, the White Sox have accumulated a defensive efficiency of 70.7% (8th in the majors).

So far in his career, Kay has conceded 163 hits and he has 143 K's in 155 innings pitched. He has given up a total of 89 earned runs while holding a WHIP of 1.534 and a FIP of 5.1. His K/BB ratio is 1.91 and he has faced 715 hitters so far in his pro baseball career. Kay (10-4 career mark) has a 5.16 ERA while giving up 9.5 hits per 9 innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Cleveland (-150)

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