Cleveland Guardians vs Chicago White Sox Prediction, 6/24/2026 MLB Picks, Best Bets & Odds

Game: Cleveland Guardians vs Chicago White Sox

Date: Wednesday, June 24, 2026

Location: Rate Field in Chicago, IL

TV: Chicago Sports Network

Odds/Point Spread: Cleveland (-128) Chicago (+106)

The Chicago White Sox (40-37) will try to beat the Cleveland Guardians (41-38) at Rate Field on Wednesday. The moneyline on this contest has Cleveland at -128 while Chicago is priced at +106. The betting total comes in at 9. The pitchers who are expected to start will be Tanner Bibee and Erick Fedde.

As a squad, the Cleveland Guardians are notching 4.0 runs per game, which has them at 28th in baseball. They have accumulated 310 runs while holding a team on-base percentage of .313. The Guardians have hit 125 doubles as a team and have hit 74 balls out of the park. They have 296 RBI's and 583 base knocks for the season, while their average at the plate comes in at .228. Cleveland has a slugging % of .370 and have struck out 627 times, while being walked on 295 occasions.

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The Guardians have a team ERA of 3.79 so far this year (6th in the league), and they have struck out 710 hitters. Guardians pitchers have surrendered 91 home runs in addition to 317 runs in total (8th in MLB). Their pitching staff has walked 257 opposing players and their FIP sits at 3.98 as a squad over the course of the season. Cleveland has conceded 610 hits (8.0 per 9 innings) in addition to 290 earned runs. Their strikeout to walk ratio sits at 2.76 and their pitching staff has recorded a WHIP of 1.26.

Guardians relief pitchers have entered the game with runners on base 69 times in addition to having 93 appearances in high leverage situations. The relief pitchers have recorded 66 holds on the campaign (1st in baseball). The Guardians bullpen have a save rate of 79.4% and have come into the game in 101 save situations. They have recorded 27 saves so far this season and have blown 7 out of their 34 save opportunities. The relief pitchers have inherited 106 base runners so far this year and 27.4% of those players ended up crossing the plate. The Guardians have sent 251 relievers to the mound for the season.

The Cleveland Guardians have earned a total of 2,065 putouts for the season, as well as 614 assists and 36 errors. Their fielding rate is at .987 which ranks 16th in professional baseball, and have a total of 56 double plays. The Guardians have transformed 70.0% of balls hit into play into outs in their 6,195 innings, ranking them 16th in professional baseball.

Bibee has pitched in 587 innings and has accounted for 568 punch outs during his MLB career. Bibee (36-31 career record) sits with a FIP of 3.62 while he has gone up against 2,421 opposing batters in the major leagues. His ERA is 3.68 (240 ER's allowed) and his WHIP is 1.175. He has surrendered 519 hits (8.0 hits per 9 innings) and has 171 free passes.

Chicago has knocked in 106 home runs so far this year as well as 337 RBIs. They have hit 104 two-baggers, while taking a walk 263 times as well as scoring 353 runs. The Chicago White Sox have compiled an OBP of .319 as well as a batting average of .237 on the year. The White Sox have a team slugging percentage of .410 and they tally 4.64 runs per contest (12th in baseball). They have been rung up on 692 occasions (5th in the league) and have totaled 598 base hits.

The White Sox are sitting with a team WHIP of 1.342 in addition to having a FIP of 4.45 as a squad this season. They currently have a strikeout to walk ratio of 8.30 (619 strikeouts vs 289 walks). They rank 13th in baseball as a staff in total hits relinquished with 612. They have given up 88 HR's and they relinquish 4.79 runs per 9 innings (19th in baseball). The Chicago pitching staff have given up 357 runs this year and come in with a team ERA of 4.41 (329 earned runs allowed).

Chicago relievers have an inherited score rate of 30.4% out of their 125 inherited base runners. Their relievers have taken the field 73 times in high leverage situations and on 83 occasions with runners on base. With 62 save situations, the White Sox have 26 holds in addition to 15 blown saves. They sit at 22nd in baseball with a save rate of 58.3%, and they have dispatched 260 relievers onto the field on the season.

Out of their 6,045 innings played, the White Sox have earned a defensive efficiency of 70.5% (12th in pro baseball). The Chicago White Sox have gotten 54 double plays and have accounted for a fielding rate of .986 (18th in baseball). The White Sox have recorded 646 assists, 39 errors and have notched a total of 2,015 putouts over the course of the season.

Fedde (36-61 win-loss mark in his career) holds a 4.90 earned run average while conceding 9.3 hits per 9 innings. He has a K/BB ratio of 1.89 and he has faced 3,669 opposing batters so far in his MLB career. He has allowed 459 earned runs while holding a WHIP of 1.436 and a FIP of 4.8. So far in his pro baseball career, Fedde has allowed 873 hits while tallying 637 K's in 842 frames.

Who will win tonight's MLB game against the spread or moneyline?

Guy Bruhn's Pick: Take Chicago (+106)

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