Cleveland Guardians vs Cincinnati Reds Prediction, 7/29/2026 MLB Picks, Best Bets & Odds

Game: Cleveland Guardians vs Cincinnati Reds

Date: Wednesday, July 29, 2026

Location: Great American Ball Park in Cincinnati, OH

TV: Reds.TV

Odds/Point Spread: Cleveland (-196) Cincinnati (+162)

The Cincinnati Reds (49-55) will compete against the Cleveland Guardians (54-53) at Great American Ball Park on Wednesday. The moneyline on this contest has the Guardians at -196 and the Reds are priced at +162. The total is set at 8. The pitchers who are expected to start will be Joey Cantillo and Rhett Lowder.

The Guardians have hit 162 doubles as a squad and have hit 104 balls out of the park. Cleveland has a slugging percentage of .371 and have been called out on strikes 895 times, while taking a walk on 381 occasions. As a team, the Cleveland Guardians are compiling 3.9 runs per game, which has them sitting at 29th in MLB. They have earned 402 runs batted in as well as 813 base knocks this year, while their team batting average sits at .230. They have notched a total of 420 runs and hold an on-base percentage of .309.

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The Guardians are sitting with a team earned run average of 3.75 this year (8th in MLB), and their staff has rung up 975 hitters. Guardians pitchers have conceded 119 home runs and 438 runs (9th in the league). They have walked 349 players from the other team and their FIP comes in at 3.89 as a team on the year. Cleveland has conceded 853 base hits (8.1 per 9 innings) in addition to 395 earned runs. They have a strikeout to walk ratio of 2.79 and the pitching staff sits with a WHIP of 1.27.

The Guardians have sent 359 relief pitchers to the hill on the campaign. The relief pitchers have inherited 162 base runners on the year and 25.3% of those players ended up scoring. The relief pitchers have 86 holds on the campaign (1st in baseball). Guardians bullpen pitchers have come into the game with runners on base 106 times in addition to having 130 appearances in high leverage situations. They have recorded 33 saves this year and have blown 10 of 43 save opportunities. The Guardians relief pitchers have accumulated a save rate of 76.7% and stepped onto the hill in 130 save situations.

The Cleveland Guardians have 2,846 putouts over the course of the season, as well as 847 assists and 57 errors. Their fielding percentage is holding at .985 which has them ranked 17th in baseball, and have 73 double plays. The Guardians have converted 69.5% of baseballs in play into outs in their 8,538 innings on the diamond, ranking them 19th in baseball.

Cantillo has taken the hill for 243 innings and is sitting with 268 strikeouts so far in his pro baseball career. Cantillo (15-13 record in his career) has earned a FIP of 3.79 while he has gone up against 1,039 hitters in the majors. His earned run average is 3.85 (104 ER's allowed) and he has a WHIP of 1.357. He has allowed 220 base knocks (8.1 hits per nine innings) and has 110 free passes.

Cincinnati has compiled 137 home runs so far this season as well as 413 RBIs. They have hit 154 doubles, while getting a free base 374 times and scoring 432 runs. The Cincinnati Reds have compiled an OBP of .308 in addition to a batting average of .230 this year. The Reds hold a team slugging percentage of .397 and they average 4.15 runs per game (26th in MLB). They have been called out on strikes on 973 occasions (4th in baseball) and have notched a total of 801 hits.

The Reds have a team WHIP of 1.421 and are the owners of a FIP of 4.83 as a team for the year. Their K/BB ratio is 8.20 (838 strikeouts vs 447 walks). They rank 16th in the league as a staff in total hits relinquished with 867. They have given up 137 long balls and they allow 4.85 runs per 9 innings (23rd in the league). The Cincinnati pitching staff have given up 498 runs so far this season while holding a team ERA of 4.52 (465 earned runs conceded).

With 101 save situations, the Reds have 58 holds and 17 blown saves. Cincinnati has called on relief pitchers to step onto the mound in 42 save chances and they have tallied 25 saves. Cincinnati relief pitchers have an inherited score percentage of 26.8% out of 164 inherited runners. Their relief pitchers have come in 125 times in high leverage situations in addition to 117 occasions with runners on. They sit at 20th in MLB with a save rate of 59.5%, and they have sent 369 bullpen pitchers to the hill over the course of the season.

In their 8,325 innings on the diamond, the Reds have accumulated a efficiency on defense of 70.5% (11th in baseball). The Cincinnati Reds have turned 75 double plays and have a fielding rate of .985 (18th in pro baseball). The Reds have recorded 847 assists, 56 errors and have earned 2,775 putouts so far this year.

So far in his pro baseball career, Lowder has given up 109 base hits while he has earned 87 K's in 107 innings. Lowder (5-9 record in his career) is the owner of a 4.37 earned run average and has given up 9.2 hits per 9 innings. He has given up 52 earned runs while holding a WHIP of 1.493 and a FIP of 4.3. He has a strikeout to walk ratio of 1.71 and he has faced 481 opposing batters in his career.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Cleveland (-196)

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