Cleveland Guardians vs Houston Astros Prediction, 6/21/2026 MLB Picks, Best Bets & Odds

Game: Cleveland Guardians vs Houston Astros

Date: Sunday, June 21, 2026

Location: Daikin Park in Houston, TX

TV: Space City Home Network

Odds/Point Spread: Cleveland (+132) Houston (-160)

The Houston Astros (36-41) will try to beat the Cleveland Guardians (40-36) at Daikin Park on Sunday. The moneyline on this contest has Cleveland at +132 while Houston is priced at -160. The betting total is set at 9. The pitchers taking the mound will be Slade Cecconi and Kai-Wei Teng.

Cleveland has a slugging percentage of .370 and have struck out 606 times, while being walked on 293 occasions. They have 287 RBI's and 569 base knocks over the course of the season, and their average at the plate comes in at .229. The Guardians have accrued 125 doubles as a unit and have smacked 71 baseballs out of the park. They have notched a total of 301 runs scored while holding a team on-base percentage of .314. As a squad, the Cleveland Guardians are knocking in 4.0 runs per contest, which ranks them 28th in baseball.

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Their K/BB ratio is 2.74 and their pitching staff holds a collective WHIP of 1.27. Guardians pitchers have surrendered 90 home runs and also 314 runs in total (10th in the league). Cleveland has conceded 598 base hits (8.0 per 9 innings) in addition to 287 earned runs. The Guardians are sitting with a team ERA of 3.85 over the course of the season (6th in MLB), and their staff has struck out 696 batters. Their pitching staff has walked 254 players from the other team and their FIP sits at 4.01 as a squad on the season.

The Guardians relief pitchers have accumulated a save percentage of 79.4% and have entered the game in 101 save situations. They have recorded 27 saves on the season and have blown 7 out of their 34 save opportunities. The relief pitchers have inherited 106 runners so far this year and 27.4% of them earned a run for their team. Guardians bullpen pitchers have gone to the mound with runners on 69 times in addition to having 93 appearances in high leverage situations. The Guardians have dispatched 248 relievers to the mound over the course of the season. The bullpen have notched 66 holds this year (1st in the league).

The Cleveland Guardians have earned a total of 2,014 putouts for the season, as well as 600 assists and 36 errors. Their fielding percentage is holding at .986 which puts them in 17th in the majors, and have accumulated 55 double plays. The Guardians have transformed 69.9% of balls hit into play into outs out of their 6,042 innings on the diamond, which ranks them 17th in professional baseball.

Cecconi has pitched in 314 frames and has accounted for 258 K's thus far in his career. His earned run average is 4.96 (173 ER's allowed) and his WHIP is 1.296. He has surrendered 329 hits (9.4 hits per 9 innings) and has had 78 walks. Cecconi (12-20 record in his career) is the owner of a FIP of 4.88 while facing 1,332 opposing batters in the majors.

Houston has a total of 102 HRs over the course of the season to go along with 338 RBIs. They have hit 129 two-baggers, while getting a free base 258 times as well as notching 353 runs. The Houston Astros have recorded an OBP of .319 in addition to a batting average of .244 so far this year. The Astros have a team SLG% of .416 and they score 4.58 runs per contest (13th in the league). They have struck out on 633 occasions (13th in baseball) and have earned 633 hits.

The Houston pitching staff have conceded 388 runs over the course of the season while holding an ERA of 4.85 (366 earned runs allowed). They have surrendered 98 dingers and they concede 5.14 runs per 9 innings (24th in baseball). The Astros hold a team WHIP of 1.415 in addition to having a FIP of 4.77 as a unit on the season. They currently have a strikeout to walk ratio of 8.70 (660 strikeouts against 344 walks). They come in at 19th in MLB as a pitching staff in total hits relinquished with 617.

Sitting with 56 save situations, the Astros have earned 31 holds and 4 blown saves. Houston has had relievers enter the contest in 25 save chances and they have converted 21 saves. Houston bullpen pitchers have an inherited score percentage of 28.7% out of 115 inherited base runners. Their relievers have stepped onto the mound 63 times in high leverage situations in addition to 74 occasions with runners on base. They rank 1st in MLB holding a save percentage of 84.0%, and they have sent 235 relief pitchers onto the diamond on the campaign.

The Houston Astros have turned 68 double plays and have accounted for a fielding rate of .989 (4th in pro baseball). The Astros have recorded 579 assists, 29 errors and have amassed 2,038 putouts this year. Out of their 6,114 innings on the field, the Astros hold a defensive efficiency of 70.4% (12th in MLB).

During his pro baseball career, Teng has given up 91 base knocks while totaling 104 strikeouts in 94 frames. He has allowed a total of 59 ER's while holding a WHIP of 1.506 and a FIP of 5.5. He has a K/BB ratio of 2.04 and he has faced 429 hitters in his pro baseball career. Teng (5-10 career record) is the owner of a 5.63 earned run average and has allowed 8.7 hits per nine innings.

Who will win tonight's MLB game against the spread or moneyline?

Josh Schonwald's Pick: Take Houston (-160)

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